what are genetic and metabolic disorders?
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A genetic disorder is a disease that is caused by an abnormality in an individual’s DNA. Abnormalities can range from a small mutation in a single gene to the addition or subtraction of an entire chromosome or set of chromosomes.\n\nI found that it is not called a metabolic disorder but a metabolic syndrome.\nThe metabolic syndrome is characterized by a group of metabolic risk factors in one person. They include:\n\nAbdominal obesity (excessive fat tissue in and around the abdomen) \nAtherogenic dyslipidemia (blood fat disorders — high triglycerides, low HDL cholesterol and high LDL cholesterol — that foster plaque buildups in artery walls) \nElevated blood pressure \nInsulin resistance or glucose intolerance (the body can’t properly use insulin or blood sugar) \nProthrombotic state (e.g., high fibrinogen or plasminogen activator inhibitor–1 in the blood) \nProinflammatory state (e.g., elevated C-reactive protein in the blood) \nPeople with the metabolic syndrome are at increased risk of coronary heart disease and other diseases related to plaque buildups in artery walls (e.g., stroke and peripheral vascular disease) and type 2 diabetes. The metabolic syndrome has become increasingly common in the United States. It’s estimated that over 50 million Americans have it.\n\nThe dominant underlying risk factors for this syndrome appear to be abdominal obesity and insulin resistance. Insulin resistance is a generalized metabolic disorder, in which the body can’t use insulin efficiently. This is why the metabolic syndrome is also called the insulin resistance syndrome.\n\nOther conditions associated with the syndrome include physical inactivity, aging, hormonal imbalance and genetic predisposition.\n\nSome people are genetically predisposed to insulin resistance. Acquired factors, such as excess body fat and physical inactivity, can elicit insulin resistance and the metabolic syndrome in these people. Most people with insulin resistance have abdominal obesity. The biologic mechanisms at the molecular level between insulin resistance and metabolic risk factors aren’t fully understood and appear to be complex.\n\nHow is the metabolic syndrome diagnosed?\nThere are no well-accepted criteria for diagnosing the metabolic syndrome. The criteria proposed by the National Cholesterol Education Program (NCEP) Adult Treatment Panel III (ATP III), with minor modifications, are currently recommended and widely used.\n\nThe American Heart Association and the National Heart, Lung, and Blood Institute recommend that the metabolic syndrome be identified as the presence of three or more of these components:\n\nElevated waist circumference:\nMen — Equal to or greater than 40 inches (102 cm)\nWomen — Equal to or greater than 35 inches (88 cm) \nElevated triglycerides:\nEqual to or greater than 150 mg/dL\nReduced HDL (“good”) cholesterol:\nMen — Less than 40 mg/dL\nWomen — Less than 50 mg/dL \nElevated blood pressure:\nEqual to or greater than 130/85 mm Hg \nElevated fasting glucose:\nEqual to or greater than 100 mg/dL \nAHA Recommendation for Managing the Metabolic Syndrome:\nThe primary goal of clinical management of the metabolic syndrome is to reduce the risk for cardiovascular disease and type 2 diabetes. Then, the first-line therapy is to reduce the major risk factors for cardiovascular disease: stop smoking and reduce LDL cholesterol, blood pressure and glucose levels to the recommended levels.\n\nFor managing both long- and short-term risk, lifestyle therapies are the first-line interventions to reduce the metabolic risk factors. These lifestyle interventions include:\n\nWeight loss to achieve a desirable weight (BMI less than 25 kg/m2) \nIncreased physical activity, with a goal of at least 30 minutes of moderate-intensity activity on most days of the week  \nHealthy feating habits that include reduced intake of saturated fat, trans fat and cholesterol \nRelated AHA Scientific Statements:\nBlood Pressure\nCholesterol\nD
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It is a hereditary condition affecting lungs or liver.  Find more here:\n\nhttp://www.netdoctor.co.uk/diseases/facts/alpha1def.htm\n\nHope that helps...
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Polycystic Kidney Disease, a progressive, genetic disorder of the kidneys, characterized by the presence of multiple cysts in both kidneys. The disease can also damage the liver, pancreas, and sometimes even the heart and brain. The two major forms of PKD are distinguished by their patterns of inheritance.  Check out the Polycystic Kidney Foundation; they have a TON of info and support materials: http://www.pkdcure.org.  Also:  The NIH - \nhttp://kidney.niddk.nih.gov/kudiseases/pubs/polycystic and the Mayo Clinic - http://www.mayoclinic.com/health/polycystic-kidney-disease/DS00245.  Good luck.
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Porphyrias are metabolic disorders of heme synthesis. Partial enzymic deficiencies result in excessive accumulation and excretion of 5-aminolevulinic acid, porphobilinogen, and/or porphyrins. Porphyria cutanea tarda (PCT) is the most common of the porphyrias in North America and Europe. Exposure of patients with PCT to sunlight results in increased skin fragility, vesicles, bullae, hypertrichosis, hyperpigmentation, sclerodermoid changes, dystrophic calcification, milia, and scarring in a photodistribution.
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Doesn't look like a sex factor:\n\nDefinition:\n\nVon Gierke disease is a group of inherited metabolic disorders that involve increased glycogen storage. Since glycogen is needed to fuel muscles, problems with its metabolism can affect the whole body.\n\nSome problems include slow growth, enlarged liver, gout, kidney failure, and chronic low blood sugar. In the past, von Gierke disease was associated with stunted growth, delayed or absent puberty, and early death.\n\nWith the development of treatments, growth, puberty, and quality of life have markedly improved for those with von Gierke disease.\nAlternative Names:\nType I glycogen storage disease\nCauses, incidence, and risk factors:\n\nAll type I glycogen storage diseases are inherited in an autosomal recessive manner. Autosomal chromosomes are the non-sex chromosomes. If both parents are carriers of the mutated gene, each of their children has a 25% chance of inheriting the disease.\n\nAll the subtypes of this disease share a common feature -- lack of proteins responsible for transporting or breaking down the components of glycogen. As a result, abnormal amounts of glycogen accumulate in various tissues, causing a wide range of symptoms.\n\nChecked 4 other sites as well.
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Ornithine transcarbamylase deficiency (OTC), the most common of the urea cycle disorders, is a rare metabolic disorder, occurring in one out of every 40000 births.  About .0025%.
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http://www.webmd.com/diseases_and_conditions/default.htm
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disease...ha ha ha ha\n\numm just a part of growing up.
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http://www.jhu.edu/\n\nmedical references\nhttp://webapps.jhu.edu/jhuniverse/medicine/diseases/
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Cystic fibrosis (CF), also called mucoviscidosis, is an autosomal recessive hereditary disease that affects the lungs, sweat glands and the digestive system.\n\nCF was first described as a disease in the late 1930s. It is the most common genetic disease among people with European ancestry. Approximately one in every 25 people of European descent is a carrier for the cystic fibrosis gene, having one normal gene and one CF gene. Since cystic fibrosis is recessive, both copies of the gene have to be CF genes to cause the symptoms that occur in about 1 in every 2500 children. The high incidence of this lethal gene can be explained by the fact that CF carriers, who don't show any symptoms, enjoy some protection against cholera, since the extreme water loss in the intestines is prevented. People from areas where cholera is not a problem show a much lower incidence of CF. Genetic counseling and genetic testing is recommended for families who may be carriers of cystic fibrosis.\n\nIn 1988, the gene for CF was discovered by Francis Collins and Lap-Chee Tsui on the seventh chromosome of the human genome.
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Poor diet, gland problems, genetic disorders, disease.
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Genetic diseases (can't correct people's genes yet)\nAIDS\nDiabetes (well, until the transplant of pancreas is discovered)
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There are several including Hemophilia, Down's Syndrome, Huntington's Chorea. The following website gives more info.
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There are very many.  Sickle cell anemia, for example, is caused by an inherited mutation in the gene for one of the subunits of hemoglobin, the oxygen-carrying protein in blood.   Certain types of cancer no doubt result from mutations in critical parts of the genome -- either induced by carcinogens or radiation, or just bad luck.  Besides mutation, there are a litany of other genetic abnormalities which can cause disease.  Huntington's disease, for example, is caused by having too many repeats of a certain DNA fragment.  Down's syndrome is caused by having an entire extra chromosome.  As you can see, DNA is the cause of many diseases, and it will be the target of many future cures as we get better at molecular therapy.
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Metabolism is the biochemical modification of chemical compounds in living organisms and cells. This includes the biosynthesis of complex organic molecules (anabolism) and their breakdown (catabolism). Metabolism usually consists of sequences of enzymatic steps, also called metabolic pathways. The total metabolism are all biochemical processes of an organism. The cell metabolism includes all chemical processes in a cell.
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It's "a disease caused by abnormal expression of one or more genes in a person causing a clinical phenotype."\n\nIt's genetic because it's not something that you can get from someone else in the traditional meaning ("I caught a cold from my wife", etc). Nor can someone with a genetic disorder infect someone else ("I infected my brother with chicken pox").
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Genetics, diet and exercise or lack thereof.