Is CFTR part of the ABC transporters?
477838
Yes.  I can't believe I just came across this question.  I'm currently preparing a talk for my company on Cystic Fibrosis.  CFTR is a member of the ATP Binding Cassette Transporter family.  It has a few differences however that set it apart from other ABC transporters.  I hope this helps you.
1164529
Visking tubing is partially permeable.\ncut 2 pices of Visking tubing 12cm long.tie one end of each with cotton.fill "cell A" with sugar solution & "cell B" with water.tie the other end & weigh each "cell".put "cell A" into a beaker of water.put "cell B" into a beaker of sugar solution.after 30 minutes reweigh each "cell".Cell A increases in weight because water has passed into the cell,into the srong solution by osmosis.Cell B decreases in weight because water has passes out of the cell,into the strong solution by osmosis.\nhope that helped-cheers!
798356
Good evening.  I'm a 39 year old CF patient so I can give you at least some insight.\n\nIn terms of costs - there are monetary, emotional and physical costs of raising any special needs child and CF is not special in that aspect.\n\nMonetary:\nMedications typically cover the respiratory and digestive aspects and will vary depending on the progression of the disease and fighting lung infections. \n*enzymes\n*bronchodialators\n*antibiotics (both oral and aerosol)\n*Pulmozyme (a specific CF aerosol drug to help liquify the mucus in the lungs in order to facilitate coughing it up and out)\n*hospitalizations for lung infections, lung collapses, etc. with courses of IV antibiotics (which may also be continued at home for a period of time)\n*CF clinic visits - usually every 2-3 months\n*diabetic medications/supplies - as we get older we usually develop a type of diabetes known as CFRD (Cystic Fibrosis Related Diabetes) which closely mirrors type 1 diabetes but has some aspects of type 2.\n*Nebulizers and associated supplies - for the aerosol medications\n*Chest physiotherapy equipment - there are manual chest physiotherapy methods and not all require equipment but each CF center/doctor has their preferred methods - some of these are purchased but others are obtained through home health rentals\n*Oxygen tanks/oxygen concentrator and supplies - may be required periodically during infections or, as the disease progresses, nightly (overnight) or even 24/7\n*Exercise equipment - it's important for CF patients to exercise and remain physically fit - exercise equipment isn't a requirement if the routine can be done without it \n*Once the disease progresses to end stages there's no option other than lung transplant (at this time).  Currently a transplant is in the range of $250,000 just for the surgery and recovery.  There are many other expenses related to the transplant process in terms of housing, etc. if temporary location is required to enable the transplant \n*Immunosuppression medications post transplant for the rest of the patient's life, as well as other meds to fight some of the side effects of the immunosuppression meds.\n\nThe costs can be several hundred to several thousand dollars a month just for the meds/equipment.  But, as a previous response noted, there are a number of programs out there to assist those without insurance or insufficient insurance coverage.\n\nEmotional - It's difficult to raise a child with an illness.  Are you too lax or too strict with the child?  Are you taking care of them the way the doctors prescribe?  Are they going to get sick?  Can you afford the medications and bills?  Can your marriage/relationships survive the additional stress of the situation?  There's often a feeling of guilt since it's a genetic illness even though the parents have no control over the gene pool.  Do you let them do things younger than most kids since they may not get to experience them if you wait until they are older to allow it?  Do you let them socialize or try to keep them away from other people to help prevent getting sick?  Do you let them slide on the medical routine or do you maintain it even though it ultimately doesn't prevent the disease from progressing?  \n\nThere's a lot to it.  CF'ers are typically rather smart and seem older than their age - we know at an early age what CF means but a lot of our "success", in addition to the medical routines, is based on the attitude of those around us - parents, other family members, teachers, etc.  If the parents have a "you can do it" attitude then the patients are likely to do well - not that we don't have times when we're down, discouraged or just really want to be "normal".  Those of us that are "babied" and spoiled tend to not do as well.\n\nPhysical - The stress of having a CF child is hard on everyone in the family.  The parents may not get enough sleep due to treatment timin
372507
It is the most common genetic disease among people with European ancestry. Approximately one in every 25 people of European descent is a carrier of one of the cystic fibrosis mutations, having one normal gene and one CF gene.Whereas, the carrier rate is 1 in 17,000 live births of African Americans, and 1 in 90,000 live births of the Asian population of Hawaii.[2]\n\nSince cystic fibrosis is recessive, both copies of the gene have to be CF genes to cause the symptoms that occur in about 1 in every 2500 children. The high incidence of this lethal gene can be explained by the fact that CF carriers, who don't show any symptoms, enjoy some protection against cholera, since the extreme water loss in the intestines is prevented. More recently, evidence suggests CF genes could give protection against typhoid fever. People from areas where cholera and typhoid fever are not problems show a much lower incidence of CF. Genetic counseling and genetic testing is recommended for families who may be carriers of cystic fibrosis.\n\nAs CF is caused by a pair of recessive gene mutations, couples with the same CF mutation will have a one in four chance that their offspring is afflicted with CF. Prenatal and preconceptional screening will identify parents at risk to have offspring with CF. Different population groups have a different prevalence of CF, thus such screening tests will be most useful in populations with a high prevalence. According to ACOG, the risk of being a carrier for an abnormal gene sequence related to CF is 1/24 for Ashkenazi Jews, 1/25 for non-Hispanic Caucasians, 1/46 for Hispanic Americans, 1/ 65 for African Americans, and 1/94 for Asian Americans. Typically one partner is screened, and if found positive the other partner undergoes the test, but in situations of time constraints, i.e. during prenatal testing, both partners may undergo testing. Genetic testing examines a panel of the most common forms of gene mutations that can lead to CF, typically 23 mutations are checked. However as over 1,300 mutations are linked to CF, there remains a residual risk even in the presence of negative testing. Couples who undergo preconceptional testing can choose among several reproductive options, including PGD prior to establishing a pregnancy, prenatal fetal testing by chorionic villus sampling or amniocentesis, or the use of alternative gametes (third party reproduction).\n\nCystic fibrosis was first described as a disease in the late 1930s by Dorothy Hansine Andersen.In 1988, the first mutation for CF, ΔF508, was discovered by Francis Collins, Lap-Chee Tsui and John R. Riordan on the seventh chromosome of the human genome. Research has subsequently found over 1000 different mutations that may cause CF, however ΔF508 accounts for approximately 70% of CF patients in Europe (this percentage varies regionally). Lap-Chee Tsui led a team of researchers at the Genomic Biology Program of the Research Institute, at The Hospital for Sick Children in Toronto to discover the gene responsible for CF in 1989.
927191
The ATP molecule is composed of three components. At the centre is a sugar molecule, ribose (the same sugar that forms the basis of DNA). Attached to one side of this is a base (a group consisting of linked rings of carbon and nitrogen atoms); in this case the base is adenine. The other side of the sugar is attached to a string of phosphate groups. These phosphates are the key to the activity of ATP.\n\nATP consists of a base, in this case adenine, a ribose and a phosphate chain.
423210
yeah, they are right, heres a site with some info:\nhttp://www.antibiotics-info.org/bact02.asp
624944
The cause of cystic fibrosis is related to an abnormality in the gene found on chromosome 7. The cause of cystic fibrosis is inherited in an autosomal resessive (pertaining to a chromosome that is not a sex chromosome) fashion.\n\nCystic fibrosis is seen most commonly in Caucasians.\n\n The cause of cystic fibrosis results in a decrease in chloride secretion across membranes and epithelial surfaces, associated with excess of sodium resorption.\n\n This results in thick secretions in the respiratory tract, and pancreas. These patients also develop dysfunctional male reproductive tracts characterized by obstruction of the vas deferens (vas deferens is a narrow, muscular tube that connects the testicles to the urethra).
73392
if you want to see more clear than the previous answer,browse from this website:\n\nhttp://pathhsw5m54.ucsf.edu/case23/PNEC.html \n\ni hope it solves your answer
166751
The binding of insulin to cell surface receptors initiates an increase in Glucose Transporter (GLUT) Proteins.\nGLUT Proteins are transmembrane molecules.\nGlucose moves into the cell - facilitated diffusion.\n\nLook here:
512503
likely to be due to the osmotic gradient set up due to the high carboydrate concentration in the cytosol.\n\non the other hand, who cares?
982139
Here it is:\nhttp://www.abccactus.com/index_1.htm
177314
Xylem in the stem, as xylem is responsible for transport of water
1074843
if it's from an area of high concentration to low concentration, it's osmosis.\n\nif it's from an area of low concentration to high concentration, it's active transport.
460267
A mono Q column is loaded with very small beads that seperate molecules, usually proteins, by anion exchange- im not sure what level of detail you want.
578235
nope.check the ABC site
1098027
Alkanes-such as methane (CH4) can pass through the lipid bilayer.
552790
"At least 97% of men with CF are sterile due to congenital bilateral aplasia of the vas deferens (CBAVD), an absence of the vas deferens. There are new technologies that are offering hope to men with CF who desire to father a child since sperm is present. This would involve aspiration and In vitro fertilization. Having a discussion with a fertility specialist would be helpful in those cases. Additionally, men who do not have cystic fibrosis but are born with congenital absence of the vas deferens have an increased risk being carriers of the CF gene.\n\nWomen with CF may also have impaired fertility, as thicker cervical mucus may prevent sperm from entering the uterus and thus reduce the likelihood of unassisted conception"