Where does aspirin affect the complement cascade.? Is it at C3, and if so, how?
407323
Aspirin and more importantly it's breakdown product, is an irreversible inhibitor of COX enzymes (non-specific, it inhibits COX-1, 2, and 3) which are critical enzymes for platelet aggragation and prostoglandin synthesis. A number of studies have failed to show an inhibition of complement with aspirin-in fact, in some subjects, aspirin actually induced c3 and c5a.  The primary anti-inflammatory effects are also through inhibition of COX enzymes, as well as inhibition of NF-kappaB, the transcription factor most responsible for TNFa production.
983918
Answer may be a response to hemostasis or the lack of hemostatis - B C and D all are involved in hemostatis more directly.  Indeed - B C and D are all part of the same process.
1109005
Aspirin can be used to prevent complications caused by having chronic high blood pressure, so it is completely normal to be on this medication.  \n\nYou should also talk to your doctor about decreasing your dose, it sounds like you are having side effects from too high of levels of the aspirin (gastric irritation AKA diarrhea and bleeding).  Drinking a lot of alchol can also increase bleeding, so be careful if you are doing that.\n\nAlso, make sure you are taking the aspirin as the doctor prescribed, not too much or too often.
364579
aspirin\nTylenol\nMotrin\nnaprosyn\nothers
1139725
Plain ole Advil doesn't not contain any aspirin... even in small amounts. \n\nHOWEVER: Ibuprofen does react with your body in a lot of similar ways to many salicylates, including acetylsalicylic acid (aspirin). That's why, if you have a reaction to Aspirin, you should watch yourself with Ibuprofen, too.
984747
None. Vinegar is acetic acid. You consume vinegar in coleslaw and pickles. \n\nOld outdated aspirins scan break down to include acetic acid.  If the thought of it bothers you toss them out. It is not a real problem otherwise.
766207
The pH of the buffered aspirin is between 8-10.  What is really important is not the pH itself but the pH at which the coating will disoolve.  You do not want the coating to dissolve at low pH in the stomach, but to do that in the relatively higher pH of the intestin where it can be absorbed.
4039
Aspirin can cause bleeding in the stomach, so some companies make a version that is coated with a substance that's supposed to prevent that bleeding.\n\nHowever, at least some studies have shown that coated aspirin may not actually reduce the bleeding.  So, it's probably not worth the extra money.\n\nAlso, there's some evidence that coated aspirin doesn't work as well as regular aspirin for reducing heart problems.
804371
My wife has been taking cellcept for her Lupus for the last two and a half years with little side effects.  She was a little sick to her stomach at first but now it really doesn't affect her.  It has done wonders for her Lupus flare ups though.  She hasn't had kidney involvement since being on the drug and she is only taking 5 mg of prednisone right now.  She also has antiocardiolipid syndrome and takes coumadin to thin her blood.  If you have any more questions or would like some more detailed info please feel free to email me
155141
not aspirin but it's parent compound salicylic acid. it reacts with iron and turns purple. it's a test for impurities in aspirin.
856340
had the same prob years ago, the antibotica was working for me 2 days i tooked the first one a little. amazing but true, i was totally ok after 11 days!!!\n\ngood luck and my best regards;\n\nLucy
11354
What about them?  Please be specific when you ask a question.\n\nIf using the Kodama pathway, you will get disulfides.
996074
aspirin comes first\n\nin the dictionary
429897
this is called the bioavailability of a drug. the aspirin is absorbed into the blood stream after being ingested, it enters the liver where it is broken down this is called 1st pass metabolism.  the remainder is utilised by the body the active ingredient.  the kidneys should not be excreting aspirin so u can not find out by this method.  most drugs have a certain calculated bioavailability so this is what you should be looking 4
806770
Yeah...turns out I have Menieres Disease and a clotting disorder called Antiphospholipid Antibody Syndrome....got on aspirin and Coumadin and things have gotten much better.  \n\nSee the links below for more information.
126520
because the main ingredient in aspirin is acid. ACETYLSALICYLIC ACID
737302
Salicylic acid - the precursor to aspirin