what is cox1 and cox2 in medicine?
110984
Cyclooxygenase (COX) is an enzyme that is responsible for formation of important biological mediators called prostanoids (including prostaglandins, prostacyclin and thromboxane). Pharmacological inhibition of COX can provide relief from the symptoms of inflammation and pain; this is the method of action of well-known drugs such as aspirin and ibuprofen.\n\nCurrently three COX isoenzymes are known—COX-1, COX-2 and COX-3.
407323
Aspirin and more importantly it's breakdown product, is an irreversible inhibitor of COX enzymes (non-specific, it inhibits COX-1, 2, and 3) which are critical enzymes for platelet aggragation and prostoglandin synthesis. A number of studies have failed to show an inhibition of complement with aspirin-in fact, in some subjects, aspirin actually induced c3 and c5a.  The primary anti-inflammatory effects are also through inhibition of COX enzymes, as well as inhibition of NF-kappaB, the transcription factor most responsible for TNFa production.
1183199
The minute a patient has a heart attack, I start ordering five drugs:  aspirin, plavix, an acei inhibitor, a beta blocker, and a statin.  Pretty standard stuff.  Pretty expensive, unfortunately.
152412
most analgesics (pain killers) are narcotics while others are salicylate and synthetic drugs.\n\nhttp://en.wikipedia.org/wiki/Analgesic\nhttp://www.encyclopedia.com/html/a1/analgesi.asp\nhttp://arthritis.about.com/od/analgesic/g/analgesic.htm\n\n<Best Answer> cause very few other users even knew what 'analgesic' meant until they read my post.
980794
Simple Biology, ask your doctor.
496617
ibuprofen is a non-steroidal anti-inflamatory drug.  So it can be used anytime one has inflamation that is not caused by infection, or for general aches and pains.  The prescription strength of this drug is 800mg.
764494
Let’s see:\nParacetamol is an analgesic antipyretic meanwhile Aspirin is an analgesic, antipyretic and anti-inflammatory. There’re 3 substances in the cells of the body called COX-1 COX-2 and COX-3 enzymes (COX-3 is not well known today) \nWhen COX-1 is active provoke augmentation fo mucocus production in the stomach which protects it from acid damage.\nWhen COX-2 is active provoke pain, swelling and fever (what we are interested in) but also bronchial constriction. \nWhen COX-3 is active provoke pain and fever.\nParacetamol works blocking COX-3 enzyme and Aspirin works blocking COX-1 and COX-2.
14143
The answer to this is that yes it can probably happen.  You should probably stop reading right here and see a doctor, but since you probably want to know more before visting a doctor I have given an explanation of this phenomenon.\n\nIbuprofen and other NSAIDs are cox enzyme inhibitors.  Nonselective NSAIDs (Ibuprofen, Aspirin, Naproxen) inhibt both cox 1 and cox 2, while cox-2 specifc NSAIDs (Celebrex) inhibit only cox 2.  Cox 2 enzymes make prostaglandins, which is a class of compounds that do many things in many different places, including an involvement in the body's inflammatory repsonse mechanism.  Prostaglandins also have a function of reducing intraocular pressure in the eye.  \n\nIn one study of the cox 2 inhibitor Celebrex, intraocular pressure increased slightly, but not signifcantly enough for concern.  NSIADs seem not to display this effect, at least not as strongly generally, but medications can have rare side effects in a small group of people. \n\nI do not know how substantial this effect is, but your eyes are sensitive and very valuable organs.  You should see the doctor.
582775
it stands for Non Steroidal Antiinflammatory drugs, which are analgesics, antipyretics, & reduce inflammation. e.g. Diclofenac "Voltaren" & Ibuprofen "Bruffen".
917863
Pain relievers are tricky meds.  Voixx was a cox-2 inhibitor, and pulled from the market, as you know, but Celebrex is still available.  Cox-2 enzyme is necessary for cardiac health, so eliminate Celebrex as a consideration.  Additonally, we are learning that Motrin (Ibuprofin) is also not really great when it comes to the heart muscle, and doctors are getting literature now that suggests it too is detrimental.  Aleve seems to be clear of any really serious side effects except that as all of the nsaid's it is bothersome to stomach.  You could try that one, if you have not already done so.  Available generic, and otc.\n\nYou may find a combination of tylenol/darvon helpful -- it's call darvocet, script only.  In the amounts generally prescribed, it is not toxic to the liver, but tylenol in huge amounts, esp with alcohol will indeed "melt" you liver.  So, if you try Darvocet, limit your alcohol intake.\n\nChronic pain is tough to deal with.  There are some new modalities available -- one is a pain delivery system to the site itself.  You'll need to see a guy who specialized in pain management, and pain management alone.  The best  oral pain relievers are those that are morphine based.  They do indeed make one a little dopey in the beginning, but one can usually push thru that, and be pretty pain free, and still alert.  The side effect, of course is constipation.
701828
your pill is a narcotic pain med called vicoprofen= the generic kind. hope thats the answer that you are looking for
120294
Aspirin and Advil are Non-Steroidal Anti-Inflammatory Drugs (NSAIDs). Aspirin irreversibly inhibits Cycloxygenase (COX)-1 and -2, which are enzyme in the inflammation pathway. Advil also inhibits COX but not irreversibly.\n\nTylenol is brand name for acetaminophen. It is not an anti-inflammatory, but it is an analgesic and anti-pyretic. It has weak anti-prostaglandin properties and is thought to work on the hypothalamus.
1049248
Tylenol   is acetaminophen\nAdvil       is ibuprofen\nAleve      is naproxen sodium\nExcedrin is aspirin
1113535
Its comman problem. in my experince most of patients do well with analgesic NSAID and antispasmodic like buscopan.
1010074
A good pharmacist would ask the doctor or the patient what is the COX-2 being used for, the reason for switching and if the patient has tried other similar medications in the past, and if they worked before.  The pharmacist should also ask about the patient's other pertinent medical history as NSAID's may not be a wise choice in a patient who has a history of kidney failure or GI bleeding.\n\nOnce all this information is elicited, then they should suggest a few that will work for the patient, keeping in mind price, effectiveness, and convenience for the patient (twice a day better than 4 times a day, etc.).
33227
tt120 sounds more like an experimental drug's name.  For example, when they were testing Vioxx, the arthritis and pain drug made by Merck, it was called MK-0966.  The generic name is rofecoxib.  More information would be needed to know what you're talking about.
1162182
I did my own personal study with it. I compared the levels of relief from Rx Ibuprofen to those from equal mg. of OTC ibuprofen. The results were pretty much the same. I have determined from this that the only difference is that you can get a larger dose of mg. in one pill through RX and therefore take fewer pills. The other advantage of Rx vs OTC is that insurance plans don't won't cover OTC but will often cover RX. Hope this is helpful to you.