This same mechanism must also be involved when diabetics' capillaries rupture and will not heal. The latter eventually causes open sores and engenders infections that eventually result in gangrene - usually in the feet and the lower legs. Thank you for your help.\nJoe Conrad
119940
In layman terms.\ndecreased or no insulin.leads to hyperglycemia. i.e raised blood sugar levels.\nwhen it crosses the renal threshold, normally 180mg/dl it starts appearing in the urine . glucose acts as an osmotic diuretic and leads to increased water loss . increased water loss leads to dehydration and thirst.\nthe mechanism for capillaries is that insuling also affects lipid metabolism. in the absence of that control, blood fats and lipids accumulate in the cappillaries forming atheromas or plaques this is known as atherosclerosis.(ATH)\nATH leads to hardening and narrowing of vessels and compromises the blood supply of organs like heart leading to myocardial infrarction and also to body extermeties like tips of fingers and toes.\nhigher insulin also leads to neuorpathy which leads to altered sensations .and loss of sensations in feet and hands.
494463
It is an extremity and requires blood to maintain the proper body temperature. Extra blood  going there to increase the temperature makes them hard
288086
Diabetes would typically numb your foot and not the thigh. \n\nThe numbness you mentioned could be due to some nerve injury caused by various reasons like too much leg exercises, long standing jobs, etc\n\nTry some heat, ice, anti inflammatory ointments.\n\nIf numbness persists for long hours visit a doc.
450046
Various cozes..\nBacterial infection, fungus, Some kind of injury....diabetes!!
532349
This is a very common occurrence, and can even happen with (severe trauma. I was just involved in a major auto accident Though I felt alright physically that day, the pain kicked in the next day and worsened over the following week or so. It's getting better, but my neck still hurts. Yes, the third site I listed (among others) does say that adrenaline can cause you not to feel pain. But there are other factors.\n\nThe doctor says this is because swelling doesn't occur right away, but when it does, it causes pain (hence the use of ice, to reduce it).\n\nAccording to the site below (painreliever.com): \n\nA. Swelling is a natural inflammatory reaction of the body to injury. It occurs when damage occurs to the small blood vessels called capillaries which leak fluid into the surrounding tissue. The increased blood flow is largely responsible for the telltale symptoms of inflammation. The rush of warm blood causes redness, heat and swelling. At the same time, pressure from the swelling and the accumulation of immune cells, along with the destructive chemicals released by the cells, irritate local nerve endings and cause pain.\n\nThree major events occur during the inflammatory response:\n\n    * Vasodialation-An increased blood supply to the tissue which signifies that tissue is ''in danger''.\n    * Increased capillary permeability- The capillaries permit larger molecules than usual to all of the cells needed for healing to get to the site faster.\n    * Infection Protection-The cells used to help fight infection seep out of the capillaries and into the injured tissue to start fighting any infection and cleaning up the injured sites bi-products. \n\nThese events signify the importance of the swelling process."\n\nThe first site suggests that endorphin es are released during significant events for the body (whether pleasure OR pain) and can control pain for awhile. This, too, would stop you from feeling pain until the endorphin es wore off. \n\nThere are many sites on how to treat injury and pain. Ice is key in the first day or so, followed by heat alternating w/ice, and anti-inflammatories like ibuprofen, or stronger Rx drugs if the injury is more severe.\n\nSince ligaments and muscles are often torn and swelling takes place at the site, it's important to rest and let healing take place. However, this can take months sometimes. \n\nIf the pain continues, I'd see a chiropractor, to readjust the various bone that were knocked out of place during the accident. This should also relieve the pain caused by pressure on nerves.\n\nGood luck to both of us, eh?
75189
Your legs may become swollen due to peripheral oedema (collection of water in the lower part of your body). Also if you do not regularly exercise a part of your body, it will get fat, and the muscles get weak.\nTo solve these problems, you should exercise regularly so that your whole body burns enough fat to prevent your legs from getting fat, and while sitting in the classroom, you can do some stretching exercises to move the fluids in your legs back up.
619935
I lost a leg from poor circulation after being diabetic for 39 years. I didn't notice my foot getting cold. I would have it checked out. It's a simple test like getting your blood pressure taken in your leg and your big toe. No pain at all. I have it done to my other leg once a year.
204897
IF you have streaks that are darker/lighter running up your ankle, that is a sure sign of bacterial infection. Bug/spider bites can give a serious infection. Sounds as if you may have brown recluse spiders in your home. Get to a doctor immediately...this is nothing to play around with. Make sure before you put your shoes on that you shake them out very well...bang them on the floor, etc.  Some spiders, including recluse and black widows, love shoes to build webs in.
317645
If your certain your not diabetic than it is time to see a Dr. and get a referal to a specialist.\nWhat you describe suggests reduced circulation and there are many conditions that this symptom can be attributed to.\n\nNeuropathy or the pain from it responds well to a med called Neurontin.\nBut I am guessing you have been treated since you seem to know the name of your condition?\n\nThis could be anything from wearing tight heels to a vascular/heart condition.\nPlease pursue this with your doctor.
455887
Well, I have 2 of them!  Seriously, you could have neuropathy.\nSymptoms depend on the type of neuropathy and which nerves are affected. Some people have no symptoms at all. For others, numbness, tingling, or pain in the feet is often the first sign. A person can experience both pain and numbness. Often, symptoms are minor at first, and since most nerve damage occurs over several years, mild cases may go unnoticed for a long time. Symptoms may involve the sensory or motor nervous system, as well as the involuntary (autonomic) nervous system. In some people, mainly those with focal neuropathy, the onset of pain may be sudden and severe.\nSymptoms may include numbness, tingling, or pain in the toes, feet, legs, hands, arms, and fingers.\nSometimes, diabetes causes neuropathy.\nMy husband takes Neurontin for his burning feet and he is not diabetic.\nI would see a doctor if this continues.
237847
It's called pitting edema and could be due to kidney problems, to vein problems, to inflammation from allergies, to heart problems...., and you should indeed see a doctor asap.
542415
Diabetes causes the accumulation of sorbitol in ur eye,causing increased pressure(glaucoma),but it doesn't help infect your eye.Diabetes in general causes complications in cases of open wounds,it promotes gangrene in big cuts,(colistridium prefrenges is sugar fermenting)
83242
Sounds like plantar fasciitis.  May be related to poor circulation, or poor fitting/supporting footwear.  If you don't smoke or have a problem with GI bleeding or PUD or NSAIDS, or have other co-morbities, you might want to try using ibuprofen for pain.  You might also want to discuss this problem with your primary care doctor.
632365
The wall of the intestine has many tiny finger like projections called Villae, these make the surface area very large.  Glucose moves throught the epithelial cells on the walls of the villae by "active transfer" a type of osmosis.  Glucose levels are maintained by the action of the hormone Insulin, failure in this system leads to the disorder Diabetes.  Search on some of these words in  google and you'll find loads of articles at different levels.  There are two site below to get you started.
31933
I don't know your history from that short blurb, but it can be a number of things, including possible vascular problems. If you are having pain at rest, it could be rather serious. Do you hang your leg off the bed at night to relieve the pain? Don't wait, make an appointment.
336726
you didn't say in what stage of diabetes you are, and how severe is your disease,and how much is it under control. but as a general rule , diabetes patients are taking longer time in healing of scars, and usually in a long term disease they have problem with the big and small vessels of their body ,specially skin tissue,which can lead to necrosis and death of that part of tissue.\n besides that in diabetes patients there is higher rates of infections(fungal,bacterial). specially if there will be a way of entry to body.that is why it is always advised to diabetic patients to avoid injury to their body (legs,feet specially) and to wash and keep clean their foot,and wear socks ,and covered shoes to decrease chances of injury.\n as a medical student i don't think it is a wise idea for you to go for tattoo , but if you really like it, consult your personal physician .
103573
They is something call Reynaud's Syndrome.  Basically it is poor circulation in people and when they get cold that happens.  Check with your doctor.