Wondering whether the complement cascade may be triggered in pregnancy to promote platelet aggregation specifically in the renal microvasculature contributing to the hypertension and renal dysfunction of serious pre-eclampsia. Even if true,\nit may not be possible to safely intervene risk/benefit wise,\nand the clinical studies to prove efficacy of pharmacologic intervention in platelet aggregation may be "un-do-able".
133561
Well, you have already drawn out the obvious link of the three-I assume you are asking what the proximal event causing the condition would be.  Hormones released during pregnancy may impact upon the COX enzyme system, increasing the sensitivity of the platelets to specific signals and thus the probability of aggragation.  There is clear indication of increased NF-kB and prostoglandin synthesis, especially in the latter stages of pregnancy, which may further exacerbate inflammatory conditions already present.  I would think, though, that it would not be an impossible thing to design an intervention.  Clearly, inhibiting NF-kB directly would be very dangerous (and likely the cause of birth defects from thalidomide, which is an NF-kB inhibitor) as would very powerful COX inhibitors, which are involved in embryonic development.  Still, one shouldn't give up hope-perhaps focusing on the local events surrounding the vasculature would be more promising than "sledgehammer" medicine in which an entire pathway is inhibited or activated throughout the body.
125109
I haven't heard about that, but you might go to the Lupus Research Foundation's website (or that of another support group for lupus) to inquire.  They may be able to point you in the right direction.
320558
I was given this drug when I had poison ivy, what are you taking it for???\nI would think it is dangerous for a baby, doesn't your doctor think so???\nI would get off of it as soon as possible if you are pregnant...\nIt is a strong drug...\nThey wouldn't let me have it very long...
380733
Platelets are activated outside the body. Sometimes it does clot inside the body unforunately.
458127
Hi there,\n\nI feel it was wrong for the doctor to assume that your otosclerosis will automatically get worse due to a pregnancy. \n\nHormone changes in pregnancy can affect otosclerosis, but only when the condition is already present. In my opinion, pregnancy may accelerate the decline, but the hearing loss is going to occur anyway.\n\nOtosclerosis is normally (but not always an inherited condition). Here is some more information:\n\nhttp://www.nidcd.nih.gov/health/hearing/otosclerosis.htm\n\nI am an audiologist, with otosclerosis throughout my family. It normally results in a severe, conductive hearing loss in both ears. However, it's normally one of the most successful types of hearing loss to treat with hearing aids.\n\nMy best advice is to discuss your situation with a different doctor, and an audiologist.
375948
these might help..\n\nhttp://www.blackwell-synergy.com/doi/abs/10.1111/j.1365-2621.2006.01347.x\n\nhttp://www.co-lipidology.com/pt/re/colipidology/abstract.00041433-200502000-00009.htm;jsessionid=Fh8fr0yV02g1pkF1LGYLXyzy9lPXZ4Gn69QZKHJ1GG1vJYGw1czy!-1640309041!-949856145!8091!-1\n\nhttp://scholar.google.com/scholar?hl=en&lr=&q=cache:yYCPrA4fU54J:bmc.ub.uni-potsdam.de/cgi-bin/show.pl%3F1475-2891-4-33/1475-2891-4-33.pdf+list+of++biochem+experiments,+TEAC+assay+or+the+phenolics+test
332103
oh my god - some of these answers are scary.\n\nthe question is very excellent though and very correct. the anti-A and anti-B CAN destroy the patients red cells if transfused to a group A or group B or group AB individual.\n\nhowever:\n\nthe antibodies are in the plasma and modern practices in blood processing split the components into their various parts - plasma and platelets and red cells. the red cells has very little plasma on them so very little anti-A or anti-B is transfused\n\ndonations with plasma on them are tested to see if the levels of anti A or anti B might be considered harmful and those donations with high titre (levels) of anti-A or anti-B are marked as not for transfusion to group A or B or AB patients.\n\nthe term universal donor is a very misleading one, in general it is true and group O can give to any other group, but precautions are necessary and are taken by transfusion services
587883
On this issue, I would agree with the pharmacist. \n Special information if you are pregnant or breastfeeding\nReturn to top\n\nBactrim should not be taken during pregnancy. If you are pregnant or plan to become pregnant, notify your doctor immediately. Bactrim does appear in breast milk and could affect a nursing infant. It should not be taken while breastfeeding. \n\nThis information I copied and pasted off the Bactrim website.  I would call the doctor back and let him/her know that you can not take this medicine.  Also when they gave you the medicine at the drug store they should have given you a information page .  I would take and read that page as well.  If it says dont take it if your a breastfeeding then don't.\nThe doctor should give you another type of medication that will help .  But as it said all med's are transfered threw breastfeeding.  Maybe u can breastpump some milk for the baby before you start taking the medicine?
438180
(Host consciousness replies)\n\nAlfacalcidol is a D vitamin. There are many D vitamins so we can't say "just vitamin D". It is actually one of the compounds produced by the kidneys following consumption of any of the D vitamins. Because you take it ready made, it can therefore bypass this renal metabolism and is considered a good choice for patients with severe impairment of kidney function. (but is also commonly given to patients with perfectly normal kidneys!)\n\nI do not know what you mean by calcium gland.\n\nVitamin D (just about any) is commony given in combination with calcium. This is because the D vits increase the absorption of calcium from food. Ie you can correct a low calcium level by taking vitamin D. Better still, give vit D and calcium supplement together. \n\nIn UK we have Cacit D3 (spelling) which contains both 500mg calcium (as carbonate) and 440 IU colecalciferol (vit D2). This is a supplement used to correct low calcium levels, typically to reduce loss of calcium from bones in post-menopausal women.\n\nSorry, as to the rest, you must discuss with GP. It is clear you have some metabolic / electrolyte imbalance. It is being treated.  Without diagnosis impossible to comment.\n\nHope above of some use to you.
671533
I had one in  Feb 06....I am still having edema,feel lousy many days,get drained really easy and still bloated..but now can urinate...my was caused by severe allergic reactions to BP meds with dyes & sulfa in them.... allergic reactions affect the kidneys....I had 6 ER visits in 10 months due to the meds I was on & latex exposures\n My new cardiologist is doing  a blood test to see if it might be a rare tumor that is increasing the chemicals in my body,causing the water retension and sluggish kidneys...he also said depending on the extent of the kidneys artery damage,it may always be like this..it takes a long time for the kidneys to get back to normal...\n <itsnanceg@yahoo.com> if you want to chat with me when  you have a down day...Best wishes for a total recovery !!!
652919
Hi.\n\nWebMD has an excellent article on this:\n\nhttp://www.webmd.com/content/article/115/111787.htm\n\n\nBest! :-)
360831
My father had this surgery after having heart problems caused by the weight. I have done a lot of research on it and have not heard of a clinical link to a post surgical link and would guess it is related to pre surgery health. My cousin who had the surgery has had deteriorarating health since surgery that they thought was heart related only to discover it was caused by severe anemia. Take your vitamins and b-12 as directed and I doubt it was the surgery but look out for other side effects.
99963
Thrombocytopenia is the medical term for "Low Platelet Levels" in the blood.  Platelets, as you might know, are the smallest membrane-bound components of the blood made in the bone marrow by cells called megakaryocytes and are released into the bloodstream.  Their major function is induction of "Hemostasis" which means control of bleeding.  When a blood vessel's integrity is compromised and bleeding ensues, certain chemicals are released from the injured vessel's cells that activate and stimulate the platelets to aggregate and form a "platelet plug." This will help stop bleeding and form a platform on top of which coagulation factors give rise to fibrin and further ensure hemostasis.\n\nSo the bottom line and summary is that platelets are involved in control of bleeding.  In certain medical conditions, the number of platelets in the blood decreases below a normal range; we call this thrombocytopenia. In this case, the patient falls under high risk of severe bleeding if injured. Therefore, as part of the nursing care for thrombocytopenic patients, one must ensure that the patient is not at high risk for falls or other types of injury that may place them at risk for excessive bleeding. Certain concommittant medical conditions such as hyperglycemia in diabetes, uremia in renal failure, immune thrombocytopenic purpura (ITP), DIC, sepsis, and patients taking blood thinners such as aspirin or clopidogrel (plavix) one must be particularly aware of the platelet status, because all of these conditions cause malfuntioning of the existing platelets and may lead to severe, even spontaneous bleeding through mucosal surfaces, intravenous lines, etc.\n\nNormal platelet rage in the blood is 150,000 to 350,000 per mL of blood.  Thrombocytopenia to as low as 50,000 may be tolerable, but lower levels are associated with higer risk of bleeding and the patient might require platelet transfusions.\n\n\nF. Rafii\nYear III Doctoral Candidate\nKeck School of Medicine\nUniversity of Southern California
236992
I'm sorry but I can't make heads or tails out of your post.  It is not clear and very confusing.  Since I can't help, due to the lack of clarity, please call your doctor tomorrow and talk to him/her.
402209
Everyone is going to scream hypertension, but it would not come on this suddenly.  Don't let them slam you with hypertensive drug therapy.  Diet is much better way to control.  Anyway you are too young and that probably is not the cause.  YOur BP is probably high do to something else going on.  One thing that can cause BP to raise is pain.  Hmmm, had any of that lately.  If you do have kidney stones, the pain could raise your BP, or a possible infection of some sort.  Either way, go get checked out and worry about the hypertension down the road.  Oh yeah, if it is hypertension, look to diet, the same thing that causes Type 2 diabetes also adds to hypertension, it usually can all be corrected with diet.   The problem is, your MD will not know how.  Check out the website below.\n\nBut yes, GO TO A DOCTOR!
293013
I know several people who have it. We have found that Guaifenesin Therapy seems to help. I've posted a link to a page that gives some info about that.
547248
*************In the second or third trimester of pregnancy, a headache could be a sign of severe preeclampsia, a serious pregnancy-induced syndrome that includes high blood pressure, protein in the urine, and other changes which can be Fatal if not treated\nAnthony EMT