what causes high creatinine levels in urine?
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Creatinine is a normal waste product that the body produces every day during muscle movements and when digesting meat. Healthy kidneys remove creatinine from the blood, and it leaves the body in urine. High levels of creatinine in the urine can indicate diabetes, high muscle tone, or problems with the kidneys.
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Hoe meer creatinine in het bloed zit, hoe slechter de nieren filtreren. Dit is mede afhankelijk van leeftijd en geslacht. Met de MDRD formule wordt het Creatine gehalte in het bloed gemeten en uitgedrukt in een getal. Dit getal heet de GFR (de glomerulaire filtratie snelheid) ofwel hoe goed filteren de nieren.
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Low values Low blood creatinine levels can mean lower muscle mass caused by a disease, such as muscular dystrophy, or by aging. Low levels can also mean some types of severe liver disease or a diet very low in protein. Pregnancy can also cause low blood creatinine levels.
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Creatinine clearance ( CrCl ) is an estimate of Glomerular Filtration Rate ( GFR ); however, CrCl is slightly higher than true GFR because creatinine is secreted by the proximal tubule (in addition to being filtered by the glomerulus). The additional proximal tubule secretion falsely elevates the CrCl estimate of GFR .
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A high uric acid level is known as hyperuricemia. This can lead to a disease called gout that causes painful joints that accumulate urate crystals. It can also make your blood and urine too acidic.
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Creatinine is removed from the blood chiefly by the kidneys, primarily by glomerular filtration, but also by proximal tubular secretion. Little or no tubular reabsorption of creatinine occurs. If the filtration in the kidney is deficient, blood creatinine concentrations rise.
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What causes nitrites in urine? The presence of nitrites in urine most commonly means there's a bacterial infection in your urinary tract. This is usually called a urinary tract infection (UTI). A UTI can happen anywhere in your urinary tract, including your bladder, ureters, kidneys, and urethra.
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Several drugs, such as cimetidine, trimethoprim, corticosteroids, pyrimethamine, phenacemide, salicylates and active vitamin D metabolites, have been reported to increase plasma creatinine without influencing its glomerular filtration.
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The amount of creatinine in the blood depends partly on the amount of muscle tissue. This means that creatinine levels are generally higher in men than in women. Also, people who have large muscles, such as athletes, normally have above-average blood creatinine levels.
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Aminoaciduria. Aminoaciduria occurs when the urine contains abnormally high amounts of amino acids. In the healthy kidney, the glomeruli filter all amino acids out of the blood, and the renal tubules then reabsorb over 95% of the filtered amino acids back into the blood.
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Creatine and phosphocreatine In muscle, creatine is phosphorylated (ATP consumption , catalyzed by creatine kinase) to phosphocreatine. Non-enzymatic cyclization of creatine forms creatinine – a waste product excreted in the urine.
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High muscle production of creatinine, especially in dog breeds with large muscle mass, such as boxers, greyhounds, sled dogs, etc. Reduction in extracellular fluid volume: dehydration may increase blood creatinine concentration when dehydration exceeds 5%.
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Greater than normal intake of water will increase the urine water content (lowering the creatinine level) consequently diluting the amount of drug in urine. Conversely, a limited intake of water can lead to an abnormally concentrated urine specimen (as occurs with dehydration) resulting in elevated creatinine levels.
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Finding microalbumin in your urine also may mean you are at a higher risk for heart disease. Higher levels of microalbumin may also be caused by blood in your urine, a urinary tract infection, and an acid-base imbalance in your blood.
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High values for both BUN and creatinine indicate that the kidneys are not working well and may be in failure. In this situation a protein:creatinine ratio greater than 0.4 in a cat and 0.5 in a dog indicates there is significant protein loss through the kidneys, and a diagnosis of primary renal disease can be made.
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A high BUN value can mean kidney injury or disease is present. Kidney damage can be caused by diabetes or high blood pressure that directly affects the kidneys. High BUN levels can also be caused by low blood flow to the kidneys caused by dehydration or heart failure.
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Creatinine can build up in the blood if a person has a kidney problem, but it can also result from a high intake of protein, intense exercise, and the use of certain medications or supplements. Doctors often use a creatinine test to determine how well the kidneys are functioning.