does grapefruit juice interfere with losartan?
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When losartan is taken with grapefruit juice, the grapefruit juice may decrease the ability of your body to activate losartan. This decreased amount of activated losartan may be insufficient to control your blood pressure.
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Statins are medicines that lower your cholesterol. Grapefruit or grapefruit juice affects some statins. Do not drink grapefruit juice if you're taking simvastatin. Grapefruit juice increases the level of simvastatin in your blood and makes side effects more likely.
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Grapefruit juice can also interfere with the metabolism of selective serotonin reuptake inhibitors, or S.S.R.I.'s, like Prozac, which are used to treat depression.
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Grapefruit also contains the soluble fiber pectin, which contributes to LDL lowering. But be aware that grapefruit can enhance the effect of certain heart medications, such as statins and calcium channel blockers. If you're on one of these drugs, check with your doctor before eating grapefruit or drinking the juice.
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When clopidogrel is taken with grapefruit juice, the grapefruit juice may prevent your body from activating clopidogrel and it may not work as well.
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Drinking cranberry juice while taking these medications might increase the effects and side effects of atorvastatin (Lipitor). Avoid drinking large amounts of cranberry juice if you are taking atorvastatin (Lipitor).
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Problems can occur for those who are sensitive to statin medications or those who have kidney disease or other illnesses. Side effects from grapefruit-statin interaction can be mild, such as muscle and joint pain. Severe side effects include muscle fiber breakdown and kidney failure.
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If you eat grapefruit or drink grapefruit juice at all, be aware that the fruit interacts with several classes of drugs, including statins (taken to lower cholesterol), beta blockers (used to treat heart disease and regulate blood pressure), immune suppressing drugs, psychotropic drugs, and even certain anesthetics.
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Eating grapefruit or drinking grapefruit juice can affect some medicines. In most cases, it increases the level of the medicine in your blood. This can increase the risk of side effects or alter the effect the medicine has.
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When quetiapine is taken with grapefruit juice, the grapefruit juice may cause the quetiapine to build up in your body. This increased amount of quetiapine can have a greater effect of both desired and undesired effects, including lethargy and dizziness.
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Potential drug interactions More than 85 drugs interact with grapefruit and some closely related citrus juices — like Seville oranges, pomelos, and tangelos. That's because chemicals in grapefruit known as furanocoumarins inhibit CYP3A4, in a similar fashion as CBD. The result is a slowed metabolization of medications.
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Eating grapefruit or drinking grapefruit juice while taking these medications can lead to higher levels of them in your blood — and more side effects. With some drugs, with even small amounts of grapefruit can cause severe side effects. Therefore, the combination should be avoided.
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Conclusions. Grapefruit juice may slightly delay the absorption of levothyroxine, but it seems to have only a minor effect on its bioavailability. Accordingly, the clinical relevance of the grapefruit juice-levothyroxine interaction is likely to be small.
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ibuprofen losartan Talk to your doctor before using losartan together with ibuprofen. Combining these medications may reduce the effects of losartan in lowering blood pressure. In addition, these medications may affect your kidney function, especially when they are used together frequently or chronically.
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Grapefruit contains a class of chemicals known to inhibit the process by which a number of drugs are broken down by the body (inactivated). This causes the concentration of drugs in the body to be higher than it should be, which can cause side effects.
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“When there is too much drug in the blood, you may have more side effects.” For example, if you drink a lot of grapefruit juice while taking certain statin drugs to lower cholesterol, too much of the drug may stay in your body, increasing your risk for liver and muscle damage that can lead to kidney failure.
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Drinking grapefruit juice improved insulin sensitivity in mice, regardless of their diet (in people, reduced insulin sensitivity can be a sign of impending diabetes). Grapefruit juice lowered blood sugar as effectively as metformin, a drug widely used to treat people with type 2 diabetes.