who sickle cell disease epidemiology?
315091
SCD affects approximately 100,000 Americans. SCD occurs among about 1 out of every 365 Black or African-American births. SCD occurs among about 1 out of every 16,300 Hispanic-American births. About 1 in 13 Black or African-American babies is born with sickle cell trait (SCT).
930656
Researchers have found that patients with sickle cell disease (SCD) have increased risk of developing leukemia, but lower risk for breast cancer or male genital cancers.
1032360
This study monitored patients in the U.S. between 1978 and 1988, and estimated the median life expectancy of women with sickle cell anemia to 48 years and men 42 years. However, it authors noted that 50 percent of deaths were seen in patients ages 45 or older.
660705
There are a paucity of data on epistaxis as it pertains to sickle cell anaemia. Some case studies suggest epistaxis to be a significant complication in patients with sickle cell anaemia in sub-Saharan Africa; however, no robust studies have sought to establish the epidemiology or pathophysiology of this phenomenon.
105648
Sickle cell disease is an inherited disease caused by defects, called mutations, in the beta globin gene that helps make hemoglobin. Normally, hemoglobin in red blood cells takes up oxygen in the lungs and carries it through the arteries to all the cells in the tissues of the body.
221841
Sickle cell disease is an inherited blood disorder marked by defective hemoglobin. It inhibits the ability of hemoglobin in red blood cells to carry oxygen. Sickle cells tend to stick together, blocking small blood vessels causing painful and damaging complications.
1307317
When a person has two hemoglobin S genes (hemoglobin SS), the disease is called sickle cell anemia. This is the most common and often most severe type of sickle cell disease. Hemoglobin SC disease and hemoglobin Sβ thalassemia are two other common types of sickle cell disease.
866713
Did you know? Sickle cell disease occurs more often among people from parts of the world where malaria is or was common. It is believed that people who carry the sickle cell trait are less likely to have severe forms of malaria.
655590
The only known cure for sickle cell disease is bone marrow or stem cell transplant.
15769
Life expectancy One often used as a baseline is the Cooperative Study of Sickle Cell Disease, published in the New England Journal of Medicine in 1994. This study monitored patients in the U.S. between 1978 and 1988, and estimated the median life expectancy of women with sickle cell anemia to 48 years and men 42 years.
569521
Sickle cell anemia is an inherited disease that affects red blood cells with an abnormal version of hemoglobin, the protein that carries oxygen throughout the body. The altered hemoglobin is known as hemoglobin S, or sickle hemoglobin, because it causes normally oval-shaped red blood cells to assume a sickle shape.
759377
What is the difference between sickle cell trait and sickle cell disease? People with sickle cell trait carry only one copy of the altered hemoglobin gene and rarely have any clinical symptoms related to the disease. In contrast, people with sickle cell disease carry two copies of the altered hemoglobin gene.
16805
Sickle cell disease is caused by a mutation in the hemoglobin-Beta gene found on chromosome 11. Hemoglobin transports oxygen from the lungs to other parts of the body. Red blood cells with normal hemoglobin (hemoglobin-A) are smooth and round and glide through blood vessels.
1118911
Sickle Cell Trait vs Sickle Cell Disease Genotypes. SCD is a complex genetic blood disorder that comprises multiple genotypes. These genotypes are characterized by a mutation in the β-globin gene that results in an abnormal hemoglobin variant called HbS.
796583
Sickle cell anemia is usually diagnosed through genetic screening done when a baby is born. Those test results will likely be given to your family doctor or pediatrician. He or she will likely refer you to a doctor who specializes in blood disorders (hematologist) or a pediatric hematologist.
119725
Sickle cell disease is the name for a group of inherited health conditions that affect the red blood cells. The most serious type is called sickle cell anaemia. Sickle cell disease is particularly common in people with an African or Caribbean family background.
244249
It is an inherited disease. People who have the disease inherit 2 copies of the gene-one from each parent. The sickle cell gene causes the body to make abnormal hemoglobin. 2 copies are needed to make the abnormal hemoglobin found in sickle cell anemia.