how long does it take for hcg to drop after misoprostol?
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However, it may take weeks for the level to decline to a normal (nonpregnant) value. Creinin and Vittinghoff37 reported that it took between 24 and 28 days following abortion with methotrexate/misoprostol for ß-hCG levels to decline to ≤ 10 IU/L.
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If the pain and bleeding have lessened or stopped completely during this time, this usually means the miscarriage has finished. You should be advised to take a home pregnancy test after 3 weeks.
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This usually takes about a month but can take more than 3 months. If your hCG levels aren't dropping enough after 1 week, you will be given another dose of methotrexate. Your hCG levels will be watched as they were after the first dose.
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If you are pregnant, your body needs time to develop detectable levels of HCG. This typically takes seven to 12 days after successful implantation of an egg. You may receive an inaccurate result if the test is taken too early in your cycle. Here are some signs that you should take a pregnancy test.
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Bleeding usually starts between 30 minutes to four hours after you place the misoprostol in your vagina. However, it can take up to 24 hours for some women. Heavy bleeding and strong cramps usually last between one and four hours.
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If you are pregnant, your body needs time to develop detectable levels of HCG. This typically takes seven to 12 days after successful implantation of an egg. You may receive an inaccurate result if the test is taken too early in your cycle.
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Unfortunately, you cannot get instant results. You need to wait to see if the embryo transfer was successful. While you may be pregnant, it can take up to two weeks for the placenta to begin producing enough hCG hormones for detection by a pregnancy test.
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The methotrexate will stop the pregnancy and the level of pregnancy hormone in your blood should decrease over 2 to 4 days.
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How does implantation affect hCG? Implantation occurs on average, 9 days after ovulation (with a range of 6-12 days) or about 5 days before a missed period. hCG levels are detected in the blood as early as 2-3 days, and in the urine 3-4 days, after implantation.
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The levels of hCG increase as your pregnancy progresses, peaking at around 8-11 weeks, before dropping to a lower level at 12 and 16 weeks. Some pregnancy test kits can detect hCG levels as low as 10 or 25mIU/ml. If you're pregnant, at 10 days past ovulation (DPO) you may be able to detect around 25mIU.
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According to the American Pregnancy Association, levels of hCG double every 2 to 3 days, peak by 8 to 11 weeks of pregnancy, and then begin to level off. HCG can usually be detected by a urine test 12 to 14 days after conception.
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This usually takes about a month but can take more than 3 months. If your hCG levels aren't dropping enough after 1 week, you will be given another dose of methotrexate.
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In the event of a miscarriage, hCG levels typically decrease from previous measurements. For example, a baseline level of 120 mIU/mL that's dropped to 80 mIU/mL two days later can indicate the embryo is no longer developing and the body isn't producing more hormones to support its growth.
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On the other hand, slow-rising hCG levels that do not double every two or three days in early pregnancy may be a sign of problems, but can also occur in a normal pregnancy. Finally, it's important to understand that hCG levels may persist for up to a few weeks after a miscarriage.
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If you're at risk for miscarriage or an ectopic pregnancy, you're more likely to have hCG levels that don't double. They may even decrease. Therefore, your doctor may ask you to return to their office two to three days after your baseline blood test to see if your level has doubled appropriately.
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The egg typically attaches 6 days after fertilization, at which point, hCG levels in your blood and urine will increase for the next 6 to 10 weeks. Once hCG levels are high enough, you can expect an accurate reading, but not before then.
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After a pregnancy loss, hCG levels will return to a non-pregnant range (less than 5 mIU/mL) between four and six weeks later.