does grapefruit juice interfere with plavix?
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When clopidogrel is taken with grapefruit juice, the grapefruit juice may prevent your body from activating clopidogrel and it may not work as well.
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Grapefruit interferes with proteins in the small intestine and liver that normally break down many medications. Eating grapefruit or drinking grapefruit juice while taking these medications can lead to higher levels of them in your blood — and more side effects.
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Instead of changing metabolism, grapefruit juice can affect proteins in the body known as drug transporters, which help move a drug into our cells for absorption. As a result, less of the drug enters the blood and the drug may not work as well, Huang says.
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Statins are medicines that lower your cholesterol. Grapefruit or grapefruit juice affects some statins. Do not drink grapefruit juice if you're taking simvastatin. Grapefruit juice increases the level of simvastatin in your blood and makes side effects more likely.
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Problems can occur for those who are sensitive to statin medications or those who have kidney disease or other illnesses. Side effects from grapefruit-statin interaction can be mild, such as muscle and joint pain. Severe side effects include muscle fiber breakdown and kidney failure.
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Grapefruit juice and certain statins (used to treat high cholesterol) such as Lipitor (atorvastatin), Mevacor (lovastatin), and Zocor (simvastatin) do not mix. Grapefruit juice inhibits a system of enzymes that helps break down dozens of medications, including Lipitor, Mevacor, and Zocor.
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Many drugs are broken down (metabolized) with the help of a vital enzyme called CYP3A4 in the small intestine. Grapefruit juice can block the action of CYP3A4, so instead of being metabolized, more of the drug enters the blood and stays in the body longer.
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Tricor Food Interactions Fenofibrate can be used with other cholesterol-lowering medicines called statins. Grapefruit and grapefruit juice may interact with statins and lead to potentially dangerous effects. Discuss the use of grapefruit products with your doctor.
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How Grapefruit Juice Affects Some Drugs. When drugs are swallowed, they may be broken down (metabolized) by enzymes and/or absorbed using transporters in cells found in the small intestine. Grapefruit juice can cause problems with these enzymes and transporters, causing too much or too little drug in the body.
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The other drawback of cranberry juice is its interaction with warfarin (Coumadin), the anticoagulant that's often prescribed to lower people's stroke risk. Some research has suggested that cranberry juice inhibits the CYP2CP enzyme in the liver that breaks down warfarin.
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Results: Grapefruit juice had no significant effect on the maximum plasma drug concentration (C(max)) of digoxin or the area under the plasma concentration-time curve (AUC) from time zero to 48 hours. However, there was a 9% increase in the digoxin AUC from time zero to 4 hours and from time zero to 24 hours (P =.
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Ibuprofen and Plavix taken together increases the risk of bleeding. Ibuprofen does have some similar anti-platelet activity as Plavix; however, ibuprofen is usually is not used as an anti-platelet medication.
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Grapefruit juice may slightly delay the absorption of levothyroxine, but it seems to have only a minor effect on its bioavailability. Accordingly, the clinical relevance of the grapefruit juice-levothyroxine interaction is likely to be small.
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Orange juice and apple juice could also interfere with some medications. And depending on the drug you're taking, the effects of your treatment could be either be blocked or boosted. This could stop the drug from helping you, or put you at risk of an overdose.
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“When there is too much drug in the blood, you may have more side effects.” For example, if you drink a lot of grapefruit juice while taking certain statin drugs to lower cholesterol, too much of the drug may stay in your body, increasing your risk for liver and muscle damage that can lead to kidney failure.
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Avoid taking Alprazolam with grapefruit juice (or grapefruit) whenever possible, and do not increase your intake of grapefruit while taking Alprazolam. You may take Alprazolam with orange juice if desired.
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Interactions between your drugs No interactions were found between grapefruit and Keppra. This does not necessarily mean no interactions exist.