Vioxx: an unequal partnership between safety and efficacy
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Last weekâs dramatic withdrawal of the COX-2 inhibitor rofecoxib (Vioxx) is discussed in this weekâs lead editorial in THE LANCET, which comments that more vigilant drug licensing is vital to prevent the endangering of patientsâ health.
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As drugmakers scramble to grab Vioxx&#39;s multi-billion-dollar share of the arthritis and pain-relief market, patients might find themselves wondering whether the competing medications are much safer.
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NEW YORK  - A new study adds to the  evidence that cardiac risk is increased in Vioxx (rofecoxib)  users, even in those without a history of heart attack. The  results also show that at lower doses of Vioxx, concurrent  aspirin use can reduce the risk and the risk decreases to  normal levels after Vioxx is discontinued.
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Suspicions that the arthritis drug Vioxx could cause serious cardiovascular damage arose as early as 1999, the year Vioxx was approved by the Food and Drug Administration as a next-generation remedy that might be safer than older drugs like ibuprofen.
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The painkiller Vioxx increases the chance of heart attack and death from cardiac arrest more than Celebrex does, according to a large study financed by the Food and Drug Administration.
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Vioxx was already a big success as an arthritis pain reliever, but Merck &amp; Co. thought it could be an even bigger seller. The drug seemed to have some cancer-prevention qualities
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The abrupt withdrawal last week of the best-selling painkiller Vioxx is an event rich in ironies and lessons that may ultimately lead to a rethinking of the way drug safety is evaluated in the United States.
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The study&#39;s findings were dramatic: 20 patients on Vioxx had heart attacks. Only four had heart attacks on the comparison drug.
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The withdrawal of Vioxx from the market in September and more recent concerns about its cousin Bextra have raised safety questions about this entire class of painkillers
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&#151; Merck & Co., the US drug maker that recalled its Vioxx painkiller because of a link to heart disease, said short-term studies show the company's planned successor pill, Arcoxia, is safer.
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Those taking Vioxx are twice as prone to cardiac problems than patients taking a placebo. Shares in Merck, the US pharmaceuticals giant, plunged by 27 per cent yesterday after the company withdrew Vioxx, its
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Now that Merck has removed its arthritis painkiller Vioxx from the market after tests found it increased the risk of heart attacks and strokes, its rival Pfizer is taking a surprising stance.
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GAITHERSBURG, Md.  - The heart attack and stroke  risks linked to withdrawn arthritis drug Vioxx are an inherent  problem for similar pain pills, Vioxx maker Merck & Co. Inc.  told advisers to the U.S. Food and Drug Administration on  Wednesday.
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People taking Vioxx may feel betrayed now that the popular painkiller and arthritis medicine has been pulled from the market. Merck, the manufacturer of the drug, and the US Food and Drug Administration knew
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With Vioxx off the market because of links to heart problems and concerns growing about the related drugs Celebrex and Bextra, a pair of Food and Drug Administration advisory committees are assessing the safety of the popular painkillers.
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Physicians and researchers estimate that Vioxx, a pain reliever found to increase cardiovascular risks, may have caused as many as 55,000 deaths in the United States.
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Now that Merck &amp; Co. has removed its arthritis painkiller Vioxx from the market after tests found that it increased the risk of heart attacks and strokes, its rival Pfizer is taking a surprising stance.