Datasets:
UMCU
/
pubmedabstracts_2025

Dataset card Data Studio Files
xet
Community
1
meta_pmid
int64
meta_language
string
meta_mesh_ids
list
meta_mesh_terms
list
meta_pubdate_year
string
meta_pubdate_month
string
text
string
91,775
eng
[ "D000367", "D002648", "D002675", "D006537", "Q000008", "Q000494", "D006801", "D007018", "Q000503", "D007223", "D007273", "D008297", "D010413", "Q000002", "Q000187", "Q000254", "Q000503", "D013739", "Q000008", "Q000494" ]
[ "Age Factors", "Child", "Child, Preschool", "Heptanoates", "Humans", "Hypopituitarism", "Infant", "Injections, Intramuscular", "Male", "Penis", "Testosterone" ]
1979
Nov
Early determination of androgen-responsiveness is important in the management of microphallus. Of fourteen boys with microphallus who were studied consecutively, nine had hypopituitarism that might otherwise have not been recognised. All fourteen were treated with low-dose, intramuscular testosterone enanthate administered in one or two 3-month courses. In each case, penile size was increased into the normal range without evoking either a significant increase in height velocity or an advancement of skeletal maturation. Before considering surgical sex reversal in infants and young children with microphallus, it is essential to assess whether treatment with intramuscular testosterone will induce clinically significant growth of the microphallus.
91,776
eng
[ "D000208", "D000293", "D000328", "D000914", "Q000276", "D002353", "Q000276", "D002908", "D000939", "D005260", "D006509", "Q000276", "D006510", "Q000276", "D006511", "Q000276", "D006514", "Q000276", "D006515", "Q000276", "D006801", "D007558", "D007564", "D008099", "Q000276", "D008297", "D014481" ]
[ "Acute Disease", "Adolescent", "Adult", "Antibodies, Viral", "Carrier State", "Chronic Disease", "Epitopes", "Female", "Hepatitis B", "Hepatitis B Antibodies", "Hepatitis B Antigens", "Hepatitis B Surface Antigens", "Hepatitis B virus", "Humans", "Italy", "Japan", "Liver", "Male", "United States" ]
1979
Nov
Incidence and significance of antibodies to delta antigen in hepatitis B virus infection. A microtitre solid-phase blocking radioimmunoassay (RIA) for antibody to the hepatitis B virus (HBV)-associated delta antigen was specific and detected anti-delta antibody at dilutions of serum of up to 10(6). Analysis of sera from HBsAg-negative subjects and different categories of HBsAg carriers from different regions confirmed the association of anti-delta antibody with HBV infection. Anti-delta antibody was detected in persistently high titres in 19.1% and 2.6% of sera from patients with chronic hepatitis and symptomatic chronic carriers, respectively, and was not detected in the sera of HBsAg-negative controls. Anti-delta antibody appeared transiently and in low titres (less than 1:500) in 4.8% of sera from patients with acute type B hepatitis. The presence and persistence of anti-delta antibody seem to be associated with chronic HBV infection and the development of progressive liver damage.
91,777
eng
[ "D000581", "Q000172", "D000649", "D001921", "Q000201", "D002518", "Q000172", "D005260", "D005347", "Q000201", "D005865", "D006579", "D006720", "D006801", "D011247", "D011296", "D013106", "Q000175", "Q000235" ]
[ "Amidohydrolases", "Amniocentesis", "Brain", "Ceramides", "Female", "Fibroblasts", "Gestational Age", "Heterozygote", "Homozygote", "Humans", "Pregnancy", "Prenatal Diagnosis", "Sphingolipidoses" ]
1979
Nov
Prenatal diagnosis of Farber's disease. Two pregnancies at risk for Farber's disease were monitored with amiocentesis at 15 and 16 weeks' gestation. In the first pregnancy tested, cultured amniotic-cell ceramidase activity was 7.8% of the control mean and an affected fetus was predicted. The pregnancy was terminated at 22 weeks' gestation and the diagnosis was confirmed by the demonstration of considerably elevated renal and hepatic ceramide concentrations and severe reduction of ceramidase activity in fetal brain and cultured fibroblasts. In the second pregnancy tested, cultured amniotic-cell ceramidase activity was within the control range, and the prediction of an unaffected fetus was confirmed in the newborn.
91,778
eng
[ "D000342", "Q000188", "Q000523", "D001127", "Q000627", "D003071", "Q000187", "D003894", "Q000494", "Q000627", "D003863", "Q000188", "Q000523", "D005069", "D006801", "D008297", "D008570", "Q000187" ]
[ "Affective Symptoms", "Arginine Vasopressin", "Cognition", "Deamino Arginine Vasopressin", "Depression", "Evaluation Studies as Topic", "Humans", "Male", "Memory, Short-Term" ]
1979
Nov
Effects of 1-desamo-8-D-arginine vasopressin on behaviour and cognition in primary affective disorder. DDAVP (1-desamino-8-d-arginine vasopressin), a synthetic analogue of vasopressin with prolonged half-life and high antidiuretic and low pressor activity, was given in a double-blind placebo-controlled trial to four patients with major affective illness. Three of four patients showed highly significant and consistent improvements in tests designed to measure the formation, encoding, and organisation of long-term trace events in memory. Two patients also showed a significant but less consistent amelioration of other depressive symptoms during DDAVP treatment. These findings implicate central vasopressin function in the processing of information and possibly other aspects of affective illness.
91,779
eng
[ "D000942", "D005802", "D006801", "D007111", "D007918", "Q000276", "Q000382", "D009166", "Q000254", "Q000276", "D010525", "Q000276", "Q000382" ]
[ "Antigens, Bacterial", "Genes, MHC Class II", "Humans", "Immunity, Cellular", "Leprosy", "Mycobacterium leprae", "Peripheral Nerves" ]
1979
Nov
Importance of the neural predilection of Mycobacterium leprae in leprosy. It is suggested that continuous leakage of bacilli into the circulation from a primary focus of intraneural infection may simultaneously initiate bacillary dissemination and the suppression of cell-mediated immunity. Both these features are essential for the development of lepromatous leprosy. Nerve involvement in leprosy, previously thought of as a diagnostic feature of the disease and as a complication of therapy, may represent an essential phase in the cycle of infection and reinfection by Mycobacterium leprae.
91,781
eng
[ "D000328", "D000368", "D004231", "D005260", "D005500", "D005656", "Q000008", "D006082", "D006085", "Q000187", "D006801", "D007166", "Q000008", "D007668", "Q000503", "D016030", "D008099", "Q000503", "D016031", "D008297", "D008875", "D010179", "Q000503", "D016035", "D010456", "Q000008", "D011183", "Q000453", "D013997", "D014184" ]
[ "Adult", "Aged", "Diuresis", "Female", "Follow-Up Studies", "Fungal Proteins", "Graft Enhancement, Immunologic", "Graft Survival", "Humans", "Immunosuppressive Agents", "Kidney", "Kidney Transplantation", "Liver", "Liver Transplantation", "Male", "Middle Aged", "Pancreas", "Pancreas Transplantation", "Peptides, Cyclic", "Postoperative Complications", "Time Factors", "Transplantation, Homologous" ]
1979
Nov
Cyclosporin A initially as the only immunosuppressant in 34 recipients of cadaveric organs: 32 kidneys, 2 pancreases, and 2 livers. 34 patients treated with cyclosporin A received 36 cadaveric organ allografts (32 kidneys, 2 pancreases, and 2 livers), 26 kidneys are still supporting life, 3 after more than a year; the pancreases and livers are also functioning. 20 patients are not receiving steroids, and 15 of these have not had any additional immunosuppressive agents. In these patients infectious complications have not been severe, but a gastroduodenal lymphoma has developed in 1 patient. 6 patients were given 'Cytimum' (a cyclophosphamide derivative) and steroids in addition to cyclosporin A: 5 of these died of infections and 1 also had a lymphoma. 11 patients received additional steroids: 1 of these died from septicaemia and lymphoma. Nephrotoxicity can be avoided by perioperative hydration and forced diuresis. Cyclosporin A is effective on its own and is a very potent immunosuppressive drug. Additional immunosuppressive agents may lead to severe complications.
91,782
eng
[ "D000818", "D005260", "D005656", "Q000008", "D006087", "Q000187", "D006789", "Q000187", "D006984", "Q000517", "D007166", "Q000008", "D066298", "D007717", "D008198", "Q000276", "Q000473", "D007959", "D017710", "D008297", "D010456", "Q000008", "D051381", "D013154", "Q000166", "D013997", "D014184" ]
[ "Animals", "Female", "Fungal Proteins", "Graft vs Host Reaction", "Host vs Graft Reaction", "Hypertrophy", "Immunosuppressive Agents", "In Vitro Techniques", "Knee", "Lymph Nodes", "Lymphocyte Culture Test, Mixed", "Lymphocyte Transfusion", "Male", "Peptides, Cyclic", "Rats", "Spleen", "Time Factors", "Transplantation, Homologous" ]
1979
Nov
Timing of cyclosporin-A therapy for abrogation of HVG and GVH responses in rats. Treatment with cyclosporin A was most effective in abrogating popliteal-lymph-node enlargement induced by host-versus-graft and graft-versus-host reactivity in rats when started before injection of donor-strain lymphocytes. Popliteal lymph-node enlargement was never completely abolished, and splenic lymphocytes from recipients treated with cyclosporin A showed no significant reduction in their response to donor-strain lymphocytes in mixed lymphocyte cultures, suggesting that clonal deletion had not taken place. Mixed lymphocyte cultures also indicated that cyclosporin treatment had not reduced the antigenicity of recipient lymphocytes towards donor strain.
91,783
eng
[ "D000230", "Q000150", "D000328", "D000368", "D001650", "Q000150", "D002404", "Q000379", "D002763", "Q000009", "D001651", "Q000209", "Q000628", "D002780", "Q000209", "Q000628", "D003135", "D003251", "Q000150", "D004322", "Q000379", "D042882", "Q000150", "D006801", "D007440", "Q000379", "D008297", "D008875", "D010166", "D010190", "Q000150" ]
[ "Adenocarcinoma", "Adult", "Aged", "Bile Duct Neoplasms", "Catheterization", "Cholecystectomy", "Cholestasis, Extrahepatic", "Cholestasis, Intrahepatic", "Common Bile Duct", "Constriction, Pathologic", "Drainage", "Gallstones", "Humans", "Intubation", "Male", "Middle Aged", "Palliative Care", "Pancreatic Neoplasms" ]
1979
Nov
Non-surgical treatment of biliary obstruction. Bileduct catheterisation percutaneously through the liver can be used in patients with obstructive jaundice as an adjunct or as an alternative to surgery. Preoperative drainage allows adequate treatment of severe cholangitis and reduces jaundice. Palliative drainage, whether internal or external, can be used instead of surgery. Drainage through the liver succeeded in 40 of 41 patients. Two complications followed the procedure and were treated conservatively. Bile drainage was established through an endoprosthesis into the duodenum in 7 patients and externally through a catheter in the remaining 33. The technique is described, and its use in patients with suppurative cholangitis and benign and malignant biliary strictures is illustrated.
91,784
eng
[ "D000328", "D001013", "D001014", "Q000150", "D001132", "Q000098", "D001157", "Q000150", "Q000175", "D001366", "D001916", "D002561", "Q000209", "D005260", "D006801", "D002542", "Q000150", "Q000209", "D002546", "Q000209", "D008297", "D008875", "D013348", "D013927", "Q000150", "Q000175" ]
[ "Adult", "Aorta, Thoracic", "Aortic Aneurysm", "Arm", "Arterial Occlusive Diseases", "Axillary Artery", "Brachial Artery", "Cerebrovascular Disorders", "Female", "Humans", "Intracranial Embolism and Thrombosis", "Ischemic Attack, Transient", "Male", "Middle Aged", "Subclavian Artery", "Thrombosis" ]
1979
Nov
Retrograde cerebral embolism. Cerebral embolism may complicate lesions of the subclavian arteries or aortic isthmus distal to the origins of the vertebral or carotid arteries. This may be due to retrograde propagation of occlusive thrombus. In other cases the vessels are patent but there are periods of reverse blood flow, creating a potential for reflux of embolic material to the ostia of the neck vessels.
91,785
eng
[ "D000293", "D004591", "Q000379", "D004910", "Q000032", "Q000378", "D004912", "Q000378", "D006455", "Q000032", "Q000652", "D006456", "Q000378", "D006801", "D008297", "D009211", "Q000097", "Q000172", "D012420", "D012967", "D013178" ]
[ "Adolescent", "Electrophoresis, Polyacrylamide Gel", "Erythrocyte Membrane", "Erythrocytes", "Hemoglobins, Abnormal", "Hemoglobinuria", "Humans", "Male", "Myoglobin", "Running", "Sodium Dodecyl Sulfate", "Sports Medicine" ]
1979
Nov
An erythrocyte membrane-protein anomaly in march haemoglobinuria. In three patients with march haemoglobinuria a well-defined protein abnormality has been revealed by high-resolution sodium-dodecyl-sulphate/polyacrylamide-gel electrophoresis.
91,786
eng
[ "D000293", "D000328", "D000941", "Q000302", "D002648", "D002675", "D005169", "Q000276", "D005260", "D006580", "D006467", "Q000235", "Q000276", "D006801", "D007123", "D007223", "D008297", "D008875", "D014842", "Q000276" ]
[ "Adolescent", "Adult", "Antigens", "Child", "Child, Preschool", "Factor VIII", "Female", "Genetic Carrier Screening", "Hemophilia A", "Humans", "Immunoelectrophoresis, Two-Dimensional", "Infant", "Male", "Middle Aged", "von Willebrand Diseases" ]
1979
Nov
Factor VIII-related antigen (VIII R:AG) in haemophilic patients and in carriers. All of fourteen patients with severe classic haemophilia and twelve of fifteen obligate carriers had a pre-peak ("rocket") above the sample well when factor VIII-related antigen was examined by crossed immunoelectrophoresis. The pre-peak may be found in other conditions--including von Willebrand's disease--but if these conditions can be excluded, the pre-peak may be helpful in identification of carriers or haemophilia.
91,787
eng
[ "D000915", "D001402", "Q000276", "D002462", "Q000276", "D003176", "Q000276", "D003298", "Q000379", "D006801", "D008214", "Q000276", "D011947", "Q000302", "D011951", "Q000302", "D011961", "Q000302", "D012397" ]
[ "Antibody Affinity", "B-Lymphocytes", "Cell Membrane", "Complement C3", "Coombs Test", "Humans", "Lymphocytes", "Receptors, Antigen, B-Cell", "Receptors, Complement", "Receptors, Fc", "Rosette Formation" ]
1979
Nov
Do human B and null lymphocytes form a single immunoglobulin-bearing population? Human "null" lymphocytes have been recognised because they lack T-lymphocyte membrane markers and the surface membrane immunoglobulin (smIg), detectable by direct immunofluorescence, which conventionally characterises B lymphocytes. But almost all null lymphocytes express smIg determinants which are demonstrable by the direct antiglobulin and mixed antiglobulin rosette tests. It is argued that the definition of a B lymphocyte should be extended to include the null cells which react in these tests. If the heterogeneity of the B-lymphocyte population is more widely recognized, the precise nature of human natural and antibody-dependent killer cells may become clearer.
91,796
eng
[ "D000367", "D000368", "D001010", "Q000209", "D003863", "Q000209", "D006233", "D005242", "Q000209", "D005260", "D006333", "Q000209", "D006801", "D008016", "D008297", "D013315", "Q000150", "Q000523", "D013406", "D013800", "D014550", "Q000209", "D014754" ]
[ "Age Factors", "Aged", "Anxiety, Separation", "Depression", "Disabled Persons", "Fecal Incontinence", "Female", "Heart Failure", "Humans", "Life Change Events", "Male", "Stress, Psychological", "Suicide, Attempted", "Theft", "Urinary Incontinence, Stress", "Violence" ]
1979
Nov
Effects of burglary and vandalism on the health of old people. The stress of burglary and vandalism can precipitate a major health crisis in old age that demands urgent admission to hospital. Despite reassurance and appropriate treatment, many patients never regain enough confidence to return home.
91,836
eng
[ "D000208", "D002986", "D003645", "Q000453", "D005260", "D005387", "D005500", "D006801", "D008297", "D008875", "D009203", "Q000401", "Q000517", "Q000534", "D011897", "D014505" ]
[ "Acute Disease", "Clinical Trials as Topic", "Death, Sudden", "Female", "Finland", "Follow-Up Studies", "Humans", "Male", "Middle Aged", "Myocardial Infarction", "Random Allocation", "Urban Population" ]
1979
Nov
Reduction in sudden deaths by a multifactorial intervention programme after acute myocardial infarction. 375 consecutive patients below 65 years who had an acute myocardial infarction (AMI) took part in a randomised rehabilitation and secondary prevention trial (part of a W.H.O.-coordinated project) designed to study the effects of a multifactorial intervention programme on morbidity, mortality, return to work, &c. After three years' follow-up the cumulative coronary mortality was significantly smaller in the intervention group than in the controls (18.6% versus 29.4%, p = 0.02). This difference was mainly due to a reduction of sudden deaths in the intervention group (5.8% versus 14.4%, p less than 0.01). The reduction was greatest during the first six months after AMI. 18.1% in the intervention group and 11.2% in the controls (p less than 0.10) presented with non-fatal reinfarctions. The number of patients with new Q-QS findings at the end of the three years was, however, almost the same in both groups. The results suggest that organised aftercare during the first six months after AMI with special emphasis on optimum medical control and health education contributes significantly to a reduction in the number of sudden deaths.
91,837
eng
[ "D000208", "D002764", "Q000175", "Q000000981", "D002765", "Q000379", "D002769", "Q000175", "D003085", "Q000175", "D003937", "D005069", "D005188", "D005704", "Q000000981", "D005971", "D006801", "D011446", "D011730", "Q000031", "D011877", "D013667", "D014463" ]
[ "Acute Disease", "Cholecystitis", "Cholecystography", "Cholelithiasis", "Colic", "Diagnosis, Differential", "Evaluation Studies as Topic", "False Negative Reactions", "Gallbladder", "Glutamates", "Humans", "Prospective Studies", "Pyridoxal", "Radionuclide Imaging", "Technetium", "Ultrasonography" ]
1979
Nov
Comparison of accuracy of 99mTc-pyridoxylidene glutamate scanning with oral cholecystography and ultrasonography in diagnosis of acute cholecystitis. A prospective study of 116 patients admitted as emergencies with a clinical diagnosis of acute cholecystitis or biliary colic has shown that the best investigation for confirming a diagnosis of acute cholecystitis is 99mTc-pyridoxylidene glutamate (PG) scanning. Its sensitivity is 99% and its specificity 86%, whereas those of oral cholecystography are 75% and 82%, respectively, and those of ultrasonography are 54% and 62%, respectively. However, estimation of plasma liver enzymes is essential to exclude acute hepatitis before proceeding to early cholecystectomy.
91,839
eng
[ "D000293", "D000936", "D002648", "D002675", "D003172", "Q000032", "D005260", "D006801", "D006942", "Q000150", "D011695", "Q000150", "Q000276", "D007105", "Q000276", "D007070", "Q000032", "Q000276", "D007074", "Q000032", "D008297", "D009393", "Q000209", "Q000276" ]
[ "Adolescent", "Antigen-Antibody Complex", "Child", "Child, Preschool", "Complement C1", "Female", "Humans", "Hypergammaglobulinemia", "IgA Vasculitis", "Immune Complex Diseases", "Immunoglobulin A", "Immunoglobulin G", "Male", "Nephritis" ]
1979
Nov
IgA immune complexes in Henoch-Schönlein purpura. Raised levels of IgA immune complexes were found in 13 of 18 children with Henoch-Schönlein purpura irrespective of whether they developed nephritis or not. In contrast, only those children who developed nephritis had raised levels of IgG immune complexes as well. In 2 children with nephritis, two discrete peaks of IgA complexes were found, corresponding to 4 x 10(5) to 8 x 10(5) and 2.5 x 10(6) to 4 x 10(6) daltons. IgG complexes were found only in the larger-molecular-weight peak. Such differences in immune complexes may underlie the different manifestations of this disease.
91,840
eng
[ "D000741", "Q000276", "D016026", "D002478", "D005260", "D005333", "D005347", "Q000382", "D006085", "D006087", "D018380", "D006801", "D007694", "Q000276", "D007938", "Q000276", "D008099", "Q000166", "D008297", "D010022", "Q000276", "D011247", "D011446", "D018139", "Q000276", "D014184" ]
[ "Anemia, Aplastic", "Bone Marrow Transplantation", "Cells, Cultured", "Female", "Fetus", "Fibroblasts", "Graft Survival", "Graft vs Host Reaction", "Hematopoietic Stem Cell Transplantation", "Humans", "Killer Cells, Natural", "Leukemia", "Liver", "Male", "Osteopetrosis", "Pregnancy", "Prospective Studies", "Simplexvirus", "Transplantation, Homologous" ]
1979
Nov
Association between pre-transplant natural kill and graft-versus-host disease after stem-cell transplantation. Natural killer activity against herpes simplex virus type 1 infected fibroblasts NK(HSV-1) was studied prospectively in patients undergoing allogenic bone-marrow or fetal-tissue stem-cell transplantation. Thirteen patients showed evidence of engraftment and survived long enough to develop graft-versus-host disease (GvHD). Of this group, all of the seven having normal NK(HSV-1) activity before transplantation acquired GvHD and the six having low NK(HSV-1) had no evidence of GvHD. These results were independent of mode of preparation of patients for transplantation, source of stem cells used, or cytomegalovirus infections, and they suggest that this assay reflects a host-determined function capable of stimulating GvHD.
91,841
eng
[ "D000328", "D000368", "D001284", "Q000378", "Q000473", "D002446", "Q000378", "Q000473", "D002463", "D004187", "Q000652", "D005260", "D006029", "Q000652", "D006801", "D007408", "D007413", "Q000473", "D007583", "Q000378", "Q000473", "D007792", "Q000652", "D008297", "D008875", "D012210", "Q000652" ]
[ "Adult", "Aged", "Atrophy", "Celiac Disease", "Cell Membrane Permeability", "Disaccharides", "Female", "Glycosuria", "Humans", "Intestinal Absorption", "Intestinal Mucosa", "Jejunum", "Lactulose", "Male", "Middle Aged", "Rhamnose" ]
1979
Nov
Abnormal intestinal permeability to sugars in villous atrophy. Intestinal permeability to a monosaccharide and a disaccharide was compared by simultaneous measurement of the urinary excretion of L-rhamnose and lactulose after oral ingestion of an hypertonic solution containing both sugars. Urine samples were analysed for sugar content by quantitative thin-layer or paper chromatography. Results in thirteen patients with untreated villous atrophy were compared with those in twelve healthy volunteers. Urinary L-rhamnose excretion was significantly decreased (-40%, p less than 0.02) in patients with villous atrophy, whereas lactulose excretion was paradoxically and significantly increased (+345%, p less than 0.01). The median value of the lactulose/L-rhamnose urinary excretion ratio was sevenfold higher in the patients with villous atrophy; there was no overlap of values for patients and volunteers (p less than 0.01). It is postulated that reduced L-rhamnose urinary excretion in untreated villous atrophy is due to a decreased absorptive area in the small bowel, whereas increased lactulose excretion indicates leakiness of the abnormal mucosa to larger polar molecules.
91,848
eng
[ "D000731", "Q000009", "D005260", "D005474", "Q000009", "D006394", "Q000139", "Q000473", "D006801", "D007006", "Q000188", "D008099", "Q000473", "D008113", "Q000139", "Q000473", "D008297", "D008599", "Q000188", "D008696", "Q000009", "D008875", "D009101", "Q000188", "D013197", "Q000009", "D013739", "Q000009" ]
[ "Androstanes", "Female", "Fluoxymesterone", "Hemangiosarcoma", "Humans", "Hypogonadism", "Liver", "Liver Neoplasms", "Male", "Menstruation Disturbances", "Methandrostenolone", "Middle Aged", "Multiple Myeloma", "Stanozolol", "Testosterone" ]
1979
Nov
Hepatic angiosarcoma associated with androgenic-anabolic steroids. A retrospective epidemiological study of deaths from hepatic angiosarcoma (HAS) in the U.S. showed that during 1964--74 there were 168 such cases, of which 37 (22%) were associated with previously known causes (vinyl chloride, 'Thorotrast', and inorganic arsenic) and 4 (3.1%) of the remaining 131 cases with the use of androgenic-anabolic steroids. It is suggested that the long-term use of androgenic-anabolic steroids is the fourth cause of HAS, the majority of cases still being of unknown aetiology. Moreover, the presented cases serve as a link in a spectrum of hepatic disorders recently recognised to be caused by environmental agents such as vinyl chloride, arsenic, and thorotrast, and by contraceptive and anabolic steroids. Similar precursor stages, usually not recognised by clinical laboratory tests and consisting of areas of hyperplasia of hepatocytes and sinusoidal cells and sinusoidal dilatation, lead potentially to hepatic adenoma, carcinoma, peliosis, and angiosarcoma.
91,886
eng
[ "D002648", "D002657", "D002986", "D003409", "Q000209", "Q000517", "D005260", "D005315", "Q000209", "D006801", "D007455", "Q000172", "D007459", "Q000008", "D008431", "D009048", "D009512", "D011247" ]
[ "Child", "Child Development", "Clinical Trials as Topic", "Congenital Hypothyroidism", "Female", "Fetal Diseases", "Humans", "Iodine", "Iodized Oil", "Maternal-Fetal Exchange", "Motor Skills", "New Guinea", "Pregnancy" ]
1979
Dec
Fetal iodine deficiency and motor performance during childhood. Motor performance of children born to mothers living in an iodine-deficient region was assessed. The mothers were participants in a controlled trial of intramuscular iodised oil in the prevention of endemic cretinism carried out in the Western Highlands of Papua New Guinea. Mothers received either iodised oil or placebo saline. Children born to mothers given iodine were significantly faster and more accurate in tests of manual function than children from control mothers. The findings indicate that iodine deficiency may lead to a spectrum of subclinical deficits which place the children at a developmental disadvantage.
91,887
eng
[ "D001769", "Q000469", "D002738", "Q000494", "D005845", "Q000208", "D006801", "D008297", "D008826", "Q000379", "D008875", "D010963", "Q000187", "Q000302", "D013636", "D014195" ]
[ "Blood", "Chloroquine", "Georgia", "Humans", "Male", "Microbial Sensitivity Tests", "Middle Aged", "Plasmodium falciparum", "Tanzania", "Travel" ]
1979
Dec
Chloroquine-resistant Plasmodium falciparum from East Africa: cultivation and drug sensitivity of the Tanzanian I/CDC strain from an American tourist. A strain of Plasmodium falciparum, designated Tanzanian I/CDC, from an American tourist returning from Tanzania, was isolated in vitro and in the Aotus monkey. Clinically, the infection showed a late recrudescent pattern of chloroquine resistance. In 2 inoculated Aotus monkeys, the infection recrudesced after a dose of chloroquine (40 mg/kg) curative for sensitive P. falciparum strains in the Aotus monkey. In 4 ,dditional monkeys two primary infections and one of the recrudescent parasitaemias were cured with a 100 mg/kg dose of chloroquine; the second recrudescent parasitaemia was cured with an additional 40 mg/kg dose of chloroquine. The 48 h in-vitro chloroquine-sensitivity test demonstrated that the Tanzanian I/CDC strain had a pattern of chloroquine resistance similar to a reference resistant strain, the Vietnam-Oak Knoll (FVO). These studies reinforce reports which suggest that chloroquine-resistant malaria is being transmitted in East Africa.
91,888
eng
[ "D000208", "D002908", "D004854", "Q000254", "D006801", "D007244", "Q000382", "D009960", "Q000382", "D010614", "Q000382", "D012463", "Q000166", "Q000382", "D012469", "Q000382", "D014069", "Q000382", "D014779" ]
[ "Acute Disease", "Chronic Disease", "Herpesvirus 4, Human", "Humans", "Infectious Mononucleosis", "Oropharynx", "Pharynx", "Saliva", "Salivary Glands", "Tonsillitis", "Virus Replication" ]
1979
Dec
Site of Epstein-Barr virus replication in the oropharynx. Cells and cell-free material in saliva, parotid secretions, and throat washings from patients with acute infectious mononucleosis and patients undergoing tonsillectomy were assayed for the presence of infectious Epstein-Barr (EBV) virus. The agent was invariably present in cell-free form in saliva; neither infectious virus nor viral antigens were found in the cells. Tonsillar lymphocytes from eight patients were also free of EBV. In 10 of 40 patients virus was recovered in secretions from parotid-gland orifices or ducts. These findings suggest that the salivary glands are the site of EBV production in the oropharynx.
91,889
eng
[ "D000328", "D000435", "Q000517", "D001786", "Q000032", "D002986", "D000431", "Q000097", "D006801", "D008297", "D009270", "Q000494", "Q000627", "D011930", "Q000187" ]
[ "Adult", "Alcoholic Intoxication", "Blood Glucose", "Clinical Trials as Topic", "Ethanol", "Humans", "Male", "Naloxone", "Reaction Time" ]
1979
Dec
Prevention of effects of alcohol intoxication by naloxone. In a double-blind, cross-over study of twenty male volunteers intravenous injection of 0.4 mg naloxone prevented the impairment of psychomotor performance induced by low levels of blood alcohol. The possibility that alcohol produces intoxication by stimulating the release of endogenous opioid peptides should be investigated.
91,890
eng
[ "D000230", "Q000175", "D002272", "Q000032", "D002294", "Q000175", "D003937", "D005260", "D006652", "D006801", "D007124", "D008649", "Q000175", "D013194", "D002583", "Q000175", "D014594", "Q000175" ]
[ "Adenocarcinoma", "Carcinoembryonic Antigen", "Carcinoma, Squamous Cell", "Diagnosis, Differential", "Female", "Histological Techniques", "Humans", "Immunoenzyme Techniques", "Mesonephroma", "Staining and Labeling", "Uterine Cervical Neoplasms", "Uterine Neoplasms" ]
1979
Dec
Distinction between endocervical and endometrial adenocarcinoma with immunoperoxidase staining of carcinoembryonic antigen in routine histological tissue specimens. The differential diagnosis of endocervical and endometrial adenocarcinomas can be improved by the demonstration of carcinoembryonic antigen (CEA) in tissue by means of immunoperoxidase staining. Tissue from 131 (80%) of 163 patients with endocervical adenocarcinoma but only 11 (8%) of 137 patients with endometrial adenocarcinoma was CEA-positive. The commonest exceptions were endocervical mesonephroid adenocarcinomas (which were CEA-negative) and endometrial adenosquamous carcinomas (which were CEA-positive). After exclusion of these on simple morphological criteria, 86 of 107 endocervical adenocarcinomas (80%) were CEA-positive, and all 122 endometrial adenocarcinomas were CEA-negative. The remarkable difference in the expression of CEA between endocervical and endometrial adenocarcinomas suggests a novel application of immunohistochemistry in routine clinical practice.
91,891
eng
[ "D000293", "D000328", "D000368", "D001798", "Q000032", "D002860", "D005188", "D005243", "Q000032", "D005260", "D006801", "D008297", "D008403", "D008875", "D011504", "Q000517", "D000515", "Q000032" ]
[ "Adolescent", "Adult", "Aged", "Blood Proteins", "Chromium Radioisotopes", "False Negative Reactions", "Feces", "Female", "Humans", "Male", "Mass Screening", "Middle Aged", "Protein-Losing Enteropathies", "alpha 1-Antitrypsin" ]
1979
Dec
Is faecal alpha 1-antitrypsin excretion a reliable screening test for protein-losing enteropathy? Estimation of alpha 1-antitrypsin in random faecal samples has been suggested as a reliable index of intestinal protein loss. There was a poor correlation between faecal alpha 1-antitrypsin concentrations and simultaneously measured faecal loss of 51Cr-albumin in twenty adults with suspected protein-losing enteropathy. This indicates that faecal alpha 1-antitrypsin estimation may not be a valid screening test for protein-losing enteropathy.
91,892
eng
[ "D000328", "D011464", "Q000378", "D005260", "D006352", "D006801", "D008168", "Q000378", "D008297", "D008875", "D011458", "Q000378", "D011651" ]
[ "Adult", "Epoprostenol", "Female", "Heart Ventricles", "Humans", "Lung", "Male", "Middle Aged", "Prostaglandins E", "Pulmonary Artery" ]
1979
Dec
Production of 6-oxo-PGF1 alpha by human lung in vivo. The production of 6-oxo-PGF1 alpha, a stable hydrolysis product of prostacyclin (PGI2), by human lung was demonstrated in five adults. The lowest increase in 6-oxo-PGF1 alpha on passage through the lung was noted in a woman on oral contraceptives.
91,900
eng
[ "D000328", "D000367", "D000919", "D002648", "D005069", "D005188", "D005189", "D005260", "D005455", "D006801", "D007668", "Q000382", "D008297", "D014513", "D001743", "Q000382", "D014546", "D014552", "Q000175" ]
[ "Adult", "Age Factors", "Antibody-Coated Bacteria Test, Urinary", "Child", "Evaluation Studies as Topic", "False Negative Reactions", "False Positive Reactions", "Female", "Fluorescent Antibody Technique", "Humans", "Kidney", "Male", "Ureter", "Urinary Bladder", "Urinary Catheterization", "Urinary Tract Infections" ]
1979
Dec
Identification of site of urinary-tract infections by antibody-coated bacteria assay. Accurate identification of the site of urinary-tract infection (UTI) may be clinically and epidemiologically valuable. A review of the literature on the assessment of the antibody-coated bacteria (ACB) assay, a non-invasive technique introducted five years ago, shows that, compared with acceptable standards (bilateral ureteral catheterization or bladder washout), the overall sensitivity of the ACB assay is 83.1%, the specificity is 76.7%, the predictive value positive is 81.3%, and the predictive value negative is 78.8%. These findings suggest that the ACB assay has at present no role in the management of patients with UTI. Its usefulness as an epidemiological tool remains to be demonstrated.
91,901
eng
[ "D000293", "D000328", "D000368", "D001795", "Q000379", "D002986", "D003971", "D004506", "D005260", "D006801", "D006973", "Q000188", "Q000517", "D008297", "D008403", "D008875", "D009785", "D009864", "D010349" ]
[ "Adolescent", "Adult", "Aged", "Blood Pressure Determination", "Clinical Trials as Topic", "Diastole", "Education, Nursing", "Female", "Humans", "Hypertension", "Male", "Mass Screening", "Middle Aged", "Occupational Health Nursing", "Ontario", "Patient Compliance" ]
1979
Dec
Work-site treatment of hypertension by specially trained nurses. A controlled trial. The clinical efficacy of using specially trained nurses to treat hypertension at the patient's place of work was compared in a controlled trial with management by the patient's family doctor. The 457 study participants were selected from 21 906 volunteers in industry and government whose blood-pressure was screened. The nurses were allowed to prescribe and change drug therapy at the work site without prior physician approval. Patients randomly allocated to receive care at work were significantly more likely to be put on antihypertensive medications (94.7% vs 62.7%, to reach goal blood-pressure in the first six months (48.5% vs 27.5%), and to take the drugs prescribed (67.6% vs 49.1%). Only 6% of patients were dissatisfied with the care provided by the nurses. Thus provision of care at work by specially tranined nurses was well accepted and resulted in significantly improved blood-pressure control and medication compliance among employees with asymptomatic and uncomplicated hypertension.
91,937
eng
[ "D002294", "Q000601", "Q000628", "D005260", "D006801", "D007013", "D008297", "D008875", "D037981", "D010166", "D010610", "Q000601", "Q000628", "D010611", "D011183", "D014831" ]
[ "Carcinoma, Squamous Cell", "Female", "Humans", "Hypopharynx", "Male", "Middle Aged", "Neck Dissection", "Palliative Care", "Pharyngeal Neoplasms", "Pharyngectomy", "Postoperative Complications", "Voice" ]
1979
Nov
Voice preservation in treatment of carcinoma of the pyriform sinus. A retrospective analysis of 175 patients having a histopathologic diagnosis of epidermoid carcinoma of the pyriform sinus presenting between January 1, 1964 and December 31, 1973 was undertaken to establish the effectiveness of conservation surgery in preserving voice. Patients were treated by three separate methods: 1. preoperative radiation therapy, partial laryngopharyngectomy and radical neck dissection (PLP and RND) (N = 85); 2. preoperative radiation therapy, total laryngopharyngectomy and radical neck dissection (TLP and RND), (N = 57); and 3. palliation, which consisted of palliative radiation therapy alone or combinations of radiation therapy and chemotherapy or palliative surgery (N = 33). Of the 85 patients treated with the expectation of cancer cure and voice preservation (PLP and RND), 44 or 52% actually had their voice preserved. Of course, in none of the patients treated by TLP and RND was voice preserved, but 2 of the 33 patients treated palliatively retained ability to speak. Overall, 46 of 175 patients (26%) with carcinoma of the pyriform sinus were afforded voice preservation. The ability to preserve voice is correlated with stage and an analysis of operative complications is presented.
91,941
rus
[ "D000596", "Q000032", "D002473", "Q000032", "D055598", "D002621", "D005419", "Q000096", "D008055", "Q000032", "D011135", "Q000032", "D013302", "Q000032", "Q000378", "D013682", "Q000032" ]
[ "Amino Acids", "Cell Wall", "Chemical Phenomena", "Chemistry", "Flavonoids", "Lipids", "Polysaccharides, Bacterial", "Streptomyces", "Teichoic Acids" ]
[Chemical composition of the cell wall of Streptomyces chrysomallus which produces the antibiotic aurantin]. The cell wall chemical composition of Streptomyces chrysomallus producing the antibiotic aurantin was studied. The cell wall represents 11--13% of the dry cell weight and contains three major polymers, namely, peptidoglycan, ribitol teichoic acid and a polysaccharide. Each muramic acid of peptidoglycan has a peptide subunit which consists of two alanine residues, glutamic acid and diaminopimelic acid residues. Peptide chains are connected with bridges consisting of one glycine residue. The poly(ribitol phosphate) chain contains glucosyl substituents and O-acetyl groups. The main monosaccharides of the polysaccharide are glucose and galactose; mannose, fucose and galactosamine are found in minor amounts. The composition of the cell wall changes during cell development and aging: the content of teichoic acid decreases while that of the polysaccharide increases. Possible factors causing these changes are discussed.
91,942
rus
[ "D000165", "Q000494", "D000935", "Q000096", "D002701", "Q000494", "D004996", "Q000494", "D005343", "Q000096", "D005419", "Q000494", "D006118", "Q000494", "D003904", "Q000187", "Q000254", "Q000378", "D011113", "Q000494" ]
[ "Acridine Orange", "Antifungal Agents", "Chloramphenicol", "Ethidium", "Fibrinolytic Agents", "Flavonoids", "Griseofulvin", "Mitosporic Fungi", "Polymyxins" ]
[Effect of protein synthesis inhibitors on the growth and biosynthetic activity of Trichothecium roseum]. The effect of inhibitors of protein synthesis on growth was studied with Trichothecium roseum producing thichothecin and fibrinolytic enzymes. Levomycetin, acridine orange and polymyxin inhibited the biomass accumulation, the growth rate, and the biosynthesis of fibrinolytic enzymes, particularly at the early stages of fungal growth. This effect was found either when the substances were added at the same time as the mycelium was inoculated, or when they were introduced 24 hours after the beginning of cultivation. The substances inhibited the differentiation of the substrate mycelium of T. roseum. Substrate conidia, budding and initial cells were formed by the mycelium only after 72--96 hours of growth.
91,944
rus
[ "D000818", "D009189", "Q000201", "D002570", "Q000096", "D004247", "Q000378", "D004926", "Q000201", "D007700", "D008099", "Q000378", "D009693", "D011061", "Q000378", "D011062", "Q000378", "D012333", "Q000378", "D012194", "Q000378", "D051381", "D013698", "D014158" ]
[ "Animals", "Avian Myeloblastosis Virus", "Ceruloplasmin", "DNA", "Escherichia coli", "Kinetics", "Liver", "Nucleic Acid Hybridization", "Poly A", "Polynucleotide Adenylyltransferase", "RNA, Messenger", "RNA-Directed DNA Polymerase", "Rats", "Templates, Genetic", "Transcription, Genetic" ]
[Enzymatic synthesis and characterization of DNA complementary to ceruloplasmin mRNA from rat liver]. Poly(A) containing rat liver 21S RNA homogeneous in polyacrylamide gel electrophoresis under denaturing conditions and stimulating the synthesis of ceruloplasmin in a cell-free proteinsynthesizing system, was used as a template for reverse transcription in the presence of T10 primer and highly purified reverse transcriptase from avian myeloblastosis virus. The cDNA made this way was characterized by means of hybridization kinetics with mRNA, by melting of the hybrids formed and by chain length measurements. To increase the degree of representativity, the ceruloplasmin mRNA was fragmented by mild alkaline treatment, enzymatically polyadenylated and transcribed. The cDNA made was fully characterized and the kinetic complexity measured by hybridization with the mRNA was found to be equal to 2300 nucleotides as compared with the value of 3000 nucleotides is expected from gel electrophoresis data. The observed difference may indicate the presence of repeated sequences in the given mRNA. The sufficient representativitness of the synthesized cDNA and its specificity with respect to ceruloplasmin mRNA allows to use it as a molecular probe to study the ceruloplasmin gene structure.
91,945
rus
[ "D000956", "Q000032", "D003090", "Q000276", "D003429", "D000939", "D007118", "D013045", "D013604", "Q000276", "D014764", "Q000276" ]
[ "Antigens, Viral", "Coliphages", "Cross Reactions", "Epitopes", "Immunoassay", "Species Specificity", "T-Phages", "Viral Proteins" ]
[Investigation of serological features and molecular heterogeneity of virion proteins of morphologically related phages]. Some interaction process peculiarites of morphologically related phate T4, DDVI and FI1 with the corresponding antiphageous sera in cross reactions of neutralisation have been investigated. Close serological relationship of phage T4 and DDVI was demonstrated. Inactivation of phage FI1 in these serological reactions showed anomalous nature and did not submit to the rules of the first step reaction. According to investigations of the protein component of virions of these phages by electrophoresis in polyacrylamide gel, phages T4 and DDVI contain twelve, FI1 and DDVI four, and T4 and FI1 two protein fractions common in molecular weight. The data obtained indicates that close serological relationship between phages T4 and DDVI is determined by the presence of common protein antigens in the absorptional apparatus of virions. Proteins of phage FI1, common with the proteins of T4 and DDVI, are obviously located in other structural components, and this determines the specific aggregation of virions in cross reactions of neutralization.
91,955
eng
[ "D000818", "D001285", "Q000494", "D004205", "Q000627", "D000242", "Q000378", "D004305", "D006636", "Q000187", "D006967", "Q000188", "D009570", "D010072", "Q000031", "D010655", "Q000627", "D010727", "Q000378", "D011813", "Q000494", "D051381", "D011950", "D011976", "D013997", "D014325", "Q000031", "Q000627", "D003189", "Q000494" ]
[ "Animals", "Atropine", "Cromolyn Sodium", "Cyclic AMP", "Dose-Response Relationship, Drug", "Histamine Release", "Hypersensitivity", "Nitriles", "Oxamic Acid", "Phenylenediamines", "Phosphoric Diester Hydrolases", "Quinuclidinyl Benzilate", "Rats", "Receptors, Cholinergic", "Receptors, Muscarinic", "Time Factors", "Tromethamine", "p-Methoxy-N-methylphenethylamine" ]
Development of new antiallergic drugs (cromolyn sodium, lodoxamide tromethamine). What is the role of cholinergic stimulation in the biphasic dose response? The antiallergy drugs, cromolyn sodium and lodoxamide tromethamine (U-42,585E) show in vitro dose responses which are bell-shaped or biphasic in mast cells. The nature of the biphasic dose response is poorly understood; however, through the use of specific antagonists, it has been possible to show that at the high concentrations of these drugs leading to enhanced histamine release or multiple high-dose tachyphylaxis, a cholinergic receptor is stimulated in the cell. This receptor is muscarinic in nature and can be blocked by atropine or quinuclidinyl benzilate (QNB). Prevention of multiple dose tachyphylaxis to either drug can be modulated by pretreatment with atropine or QNB. High concentrations of both drugs cause the cell accumulation of cyclic-guanosine monophosphate through stimulation of guanyl cyclase and prevention of cGMP breakdown by inhibition of the phosphodiesterase (PDE) for cGMP.
91,959
eng
[ "D000284", "D000402", "Q000188", "D000818", "D001393", "Q000627", "D004305", "D006168", "D006634", "D006636", "Q000187", "D006967", "Q000188", "D006969", "Q000276", "D008297", "D010323", "D011744", "Q000627", "D051381", "D013777", "Q000627" ]
[ "Administration, Oral", "Airway Obstruction", "Animals", "Azoles", "Dose-Response Relationship, Drug", "Guinea Pigs", "Histamine H1 Antagonists", "Histamine Release", "Hypersensitivity", "Hypersensitivity, Immediate", "Male", "Passive Cutaneous Anaphylaxis", "Pyrimidinones", "Rats", "Tetrazoles" ]
BL-5255, a tetrazolylpyrimidinone with potent oral antiallergy activity in animals. BL-5255, 2-(2-n-propoxyphenyl)-5-(5-1 H-tetrazolyl)pyrimidin-4 (3H)-one, effectively inhibited allergic reactions in sensitized rats or guinea pigs when administered by oral or intravenous routes as the water-soluble sodium or ethanolamine monohydrate salts. In the IgE-mediated rat PCA, BL-5255 was 50 times more potent than disodium cromoglycate by intravenous administration. When administered orally in this model, BL-5255 inhibited the PCA reaction by 50% at 0.1 mg/kg. At less than 0.1 mg/kg p.o., the compound protected conscious actively sensitized guinea pigs from aerosolized antigen-induced collapse. In N. brasiliensis-sensitized rats, BL-5255 administered at 0.1--10 mg/kg p.o. inhibited antigen-induced airway constriction in a dose-related manner. BL-5255 is not a histamine or serotonin antagonist but appears to exert its antiallergic effect by inhibiting the release of mediators.
91,973
eng
[ "D000222", "D000251", "Q000378", "D000818", "D006332", "Q000201", "D000939", "D007527", "Q000378", "D008297", "D009200", "D015879", "Q000378", "D009218", "Q000276", "Q000378", "D051381" ]
[ "Adaptation, Physiological", "Adenosine Triphosphatases", "Animals", "Cardiomegaly", "Epitopes", "Isoenzymes", "Male", "Myocardial Contraction", "Myosin Subfragments", "Myosins", "Rats" ]
1979
Nov
Myosin isoenzyme redistribution in chronic heart overload. Since the first observation by Spann et al., it has become clear that in cardiac hypertrophy induced by a mechanical overloading, the velocity of shortening of the cardiac muscle (Vmax) is reduced (see ref. 2 for review). Most authors agree that this mechanical alteration is accompanied by a decrease in the Ca2+-dependent ATPase activity of myosin (see ref. 3 for review). The molecular basis of such changes was unknown because the structural modifications of the myosin molecule were ill-defined. Nevertheless, it has recently been shown that, like skeletal muscle myosin, cardiac myosin is composed of several polymorphic forms, comparable to isoenzymes. In the skeletal muscle, new functional requirements can induce changes in both contractile activity and type of myosin isoenzyme synthesised. We now report that an increase in cardiac work produced by mechanical overloading in rats induces the preferential synthesis of a cardiac myosin isoenzyme characterised by specific immunological and electrophoretic properties and exhibiting a lower ATPase activity. This adaptive change could account for the reduced shortening speed of this hypertrophied cardiac muscle.
91,974
eng
[ "D000595", "D000818", "D000917", "D000918", "D000941", "D001323", "D001324", "D005075", "D003574", "Q000276", "D000939", "D007108", "D008297", "D010446", "Q000276", "D011487", "D011817", "D013045" ]
[ "Amino Acid Sequence", "Animals", "Antibody Formation", "Antibody Specificity", "Antigens", "Autoantibodies", "Autoantigens", "Biological Evolution", "Cytochrome c Group", "Epitopes", "Immune Tolerance", "Male", "Peptide Fragments", "Protein Conformation", "Rabbits", "Species Specificity" ]
1979
Nov
Specificity of the antibody response of rabbits to a self-antigen. The demonstration that the antigenic determinants on rabbit cytochrome c that elicit antibodies in rabbits occur in regions of variability among mammalian cytochromes c suggests the existence of an evolutionary process which eliminates genetic specificities for self-determinants.
91,977
eng
[ "D000818", "D001001", "D002118", "Q000378", "D001556", "Q000494", "D066298", "D009045", "Q000187", "D009469", "Q000187", "Q000378", "D018377", "Q000378", "D011896", "D013997" ]
[ "Animals", "Anura", "Calcium", "Hexachlorocyclohexane", "In Vitro Techniques", "Motor Endplate", "Neuromuscular Junction", "Neurotransmitter Agents", "Rana temporaria", "Time Factors" ]
1979
Aug
The action of lindane in accelerating the spontaneous release of transmitter at the frog neuromuscular junction. Lindane (5 x 10(-5) M) causes a progressive and marked rise in MEPP frequency at the frog neuromuscular junction. Concentrations over a range of 5 x 10(-6) M to 5 x 10(-4) M were tested. The results suggest that it has two actions in promoting this effect. Its major effect is probably to cause an increase in Ca2+-permeability and a rise in Ca2+ entry. Its second, smaller effect, which persists in the absence of extracellular Ca2+, is probably also because of a rise in [Ca2+]i. The ways in which these effects might be produced and the significance of these findings for explaining the known pharmacological actions of lindane are discussed.
91,976
eng
[ "D015056", "Q000494", "D000818", "D002417", "D003331", "Q000187", "Q000378", "D000242", "Q000378", "D004176", "Q000494", "D011464", "Q000494", "D066298", "D007213", "Q000494", "D011453", "Q000494", "D013268", "D013806", "Q000031", "D013997" ]
[ "1-Methyl-3-isobutylxanthine", "Animals", "Cattle", "Coronary Vessels", "Cyclic AMP", "Dipyridamole", "Epoprostenol", "In Vitro Techniques", "Indomethacin", "Prostaglandins", "Stimulation, Chemical", "Theophylline", "Time Factors" ]
1979
Aug
PGI2 enhanced cAMP content in bovine coronary arteries in the presence of isobutylmethylxanthine. Incubation of bovine coronary artery (BCA) rings with isobutylmethylxanthine (IBMX) resulted in a time-dependent increase of cAMP content. This effect was blocked, when the rings were preincubated with indomethacine or 15-hydroperoxy-arachidonic acid for 5 min, indicating that the IBMX-induced increase in cAMP content may depend on endogenous PGI2 formation. PGE2 did not increase the cAMP content in BCA rings. Dipyridamole did not effect cAMP content, when used as a substitute for IBMX. It is suggested that PGI2 stimulates cAMP formation in arterial walls, but that this effect only becomes visible in the presence of a phosphodiesterase inhibitor.
91,999
ger
[ "D000367", "D001424", "Q000276", "D001812", "D002556", "Q000032", "D002648", "D002675", "D006801", "D007070", "Q000276", "D007071", "Q000276", "D007074", "Q000276", "D007223", "D008581", "Q000134", "Q000209", "Q000276", "D008587", "Q000134", "Q000276", "D000511", "Q000276" ]
[ "Age Factors", "Bacterial Infections", "Blood-Brain Barrier", "Cerebrospinal Fluid Proteins", "Child", "Child, Preschool", "Humans", "Immunoglobulin A", "Immunoglobulin A, Secretory", "Immunoglobulin G", "Infant", "Meningitis", "Meningitis, Viral", "alpha-Macroglobulins" ]
1979
Aug
[Blood-cerebrospinal fluid barrier and the local immune response in the course of meningitis in childhood]. The condition of the blood-CSF barrier can be evaluated by the simultaneous quantitation of marker proteins in serum and cerebrospinal fluid. The concentration ratios of albumin and alpha 2-macroglobulin, plotted versus the hydrodynamic radii are used as permeability parameter. There are wide ranging barrier disturbances during the early stages of meningitis. In mumps meningitis only slight disturbances were found, meanwhile in bacterial meningitis the barrier permeability was strongly increased. In both disease groups one may detect secretory fractions of both immunglobulins G and A. In some cases of mumps meningitis a prolonged humoral immune reaction was found.
92,002
fre
[ "D000818", "D003594", "Q000648", "D005260", "D006003", "Q000378", "D006023", "Q000378", "D006056", "Q000648", "D006651", "D007606", "Q000378", "Q000648", "D008247", "Q000648", "D051379", "D013194" ]
[ "Animals", "Cytoplasmic Granules", "Female", "Glycogen", "Glycoproteins", "Golgi Apparatus", "Histocytochemistry", "Juxtaglomerular Apparatus", "Lysosomes", "Mice", "Staining and Labeling" ]
1979
May
[Ultrastructural cytochemistry of the mouse juxtaglomerular apparatus (author's transl)]. The ultrastructural cytochemistry of the mouse juxtaglomerular apparatus has been studied. The specific granules of the juxtaglomerular cells were found to be argentaphobic when ultrathin sections of araldite-embedded renal cortex were stained according to the periodic acid-thio-carbohydrazide-silver proteinate technique of Thiery. This technique revealed an abundant glycogen of type beta in the specific granules and in the cytosol of these cells. The rim of specific granules was positive when ultrathin sections of glutaraldehyde-fixed, glycol methacrylate-embedded kidneys were stained with phosphotungstic-hydrochloric acids at a low pH. A reaction was also shown by the cell coat, lysosomes, autophagolysosomes, residual bodies and part of the Golgi complex. These results indicate that the specific granules of the mouse juxtaglomerular apparatus contains glycoproteins that are glycosylated in the Golgi complex.
92,003
fre
[ "D000328", "D005260", "D005455", "D006514", "Q000032", "D006525", "Q000276", "Q000473", "D006801", "D008099", "Q000473", "Q000648", "D008297", "D008854", "D013194" ]
[ "Adult", "Female", "Fluorescent Antibody Technique", "Hepatitis B Surface Antigens", "Hepatitis, Viral, Human", "Humans", "Liver", "Male", "Microscopy, Electron", "Staining and Labeling" ]
1979
May
[Microscopic, immunochemical and ultrastructral study of livers histologically normal or subnormal in patients with hepatitis B surface antigen (HBs). Report of 18 cases (author's transl)]. Liver specimens obtained by biopsy in 18 patients with asymptomatic HBs Ag were studied with specific immunofluorescent technic for this antigen by light and electron microscopy. Only insignificant changes were disclosed by routine microscopy examination. Under light microscopy "ground glass" hepatocytes were found in eight cases. Specific immunofluorescence was found positive in nine cases and was closely correlated with the "ground glass" hepatocytes in eight of them. In one on the three cases studied by electron microscopy, only spherical and tubular formations, 20 to 30 nm in diameter found in the cisternae of the smooth endoplasma reticulum in a few hepatocytes, seem to be HBs Ag.
92,005
eng
[ "D001120", "D001798", "Q000378", "D003550", "Q000097", "D004591", "D010450", "Q000097", "D004950", "Q000097", "D006801", "D007122", "D007074", "Q000378", "D007457", "D011485", "D014357", "Q000097", "D000511", "Q000378" ]
[ "Arginine", "Blood Proteins", "Cystic Fibrosis", "Electrophoresis, Polyacrylamide Gel", "Endopeptidases", "Esterases", "Humans", "Immunoelectrophoresis", "Immunoglobulin G", "Iodine Radioisotopes", "Protein Binding", "Trypsin", "alpha-Macroglobulins" ]
1979
Sep
Binding of 125I-labeled proteinases to plasma proteins in cystic fibrosis. Samples of plasma or serum from 53 cystic fibrosis (CF) patients, 90 relatives of CF patients , and 159 controls have been incubated with porcine or bovine 125I-trypsin, electrophoresed on polyacrylamide gel, and autoradiographed. In these individuals, the main binding protein for 125I-trypsin has been shown to be alpha 2-macroglobulin (alpha 2M). Using this method of analysis, no difference in electrophoretic migration of 125I-trypsin-alpha 2M complexes has been observed between CF and control individuals. However, trypsin binding to IgG has been observed in 80% of CF patients, 30% of their mothers, 3% of controls, and in two patients affected with pancreatitis. These trypsin binding immunoglobulins are called TbIg, and specifically, Tb1gG when referring to the G class. Experimental evidence indicates that binding of trypsin to IgG occurs through the Fab portion of the molecule. Tb1gG must be antibodies most probably induced by the exogenous trypsin ingested daily by most CF patients (and by patients affected with chronic pancreatitis). Antibodies against porcine pancreatic elastase have been observed using the same analysis, but not as frequently as Tb1g.
92,010
eng
[ "D000818", "D001761", "Q000494", "D004260", "D004262", "D004273", "Q000378", "Q000528", "D004277", "Q000528", "D004307", "D006861", "Q000494", "D007700", "D007939", "Q000378", "D051379" ]
[ "Animals", "Bleomycin", "DNA Repair", "DNA Restriction Enzymes", "DNA, Neoplasm", "DNA, Single-Stranded", "Dose-Response Relationship, Radiation", "Hydrogen Peroxide", "Kinetics", "Leukemia L1210", "Mice" ]
1979
Oct
X-ray induced DNA double strand break production and repair in mammalian cells as measured by neutral filter elution. This work presents a neutral filter elution method for detecting DNA double strand breaks in mouse L1210 cells after X-ray. The assay will detect the number of double strand breaks induced by as little as 1000 rad of X-ray. The rate of DNA elution through the filters under neutral conditions increases with X-ray dose. Certain conditions for deproteinization, pH, and filter type are shown to increase the assay's sensitivity. Hydrogen peroxide and Bleomycin also induce apparent DNA double strand breaks, although the ratios of double to single strand breaks vary from those produced by X-ray. The introduction of double strand cuts by HpA I restriction endonuclease in DNA lysed on filters results in a rapid rate of elution under neutral conditions, implying that the method can detect double strand breaks if they exist in the DNA. The eluted DNA bands with a double stranded DNA marker in cesium chloride. This evidence suggests that the assay detects DNA double strand breaks. L1210 cells are shown to rejoin most of the DNA double strand breaks induced by 5-10 krad of X-ray with a half-time of about 40 minutes.
92,012
eng
[ "D009189", "Q000201", "D004277", "D004279", "Q000096", "D005814", "D008722", "D009693", "D009975", "Q000378", "D012333", "Q000378", "D012194" ]
[ "Avian Myeloblastosis Virus", "DNA, Single-Stranded", "DNA, Viral", "Genes, Viral", "Methods", "Nucleic Acid Hybridization", "Orthomyxoviridae", "RNA, Messenger", "RNA-Directed DNA Polymerase" ]
1979
Nov
New procedure for the production of influenza virus-specific double-stranded DNA's. A novel technique is described for the production of pure, full-length influenza virus ds DNA's corresponding to each segment of the influenza virus genome, and suitable for molecular cloning and restriction endonuclease mapping. The method involves the synthesis of DNA complementary to both virion (negative strand) and messenger (positive strand) RNA, gel purification and annealing. By avoiding the use of SI nuclease, which often removes the terminal regions of DNA duplexes, the method allows transcription of the total sequence information of influenza virion and messenger RNA's into a ds DNA form.
92,011
eng
[ "D001482", "D001483", "D009029", "Q000032", "D009690", "D009693", "D009843", "Q000032", "D011061", "D012367", "Q000302", "D012194" ]
[ "Base Composition", "Base Sequence", "Mosaic Viruses", "Nucleic Acid Conformation", "Nucleic Acid Hybridization", "Oligoribonucleotides", "Poly A", "RNA, Viral", "RNA-Directed DNA Polymerase" ]
1979
Oct
Extensive sequence homology at the 3'-termini of the four RNAs of cucumber mosaic virus. The sequences of 270 residues from the 3'-termini of the four RNAs of cucumber mosaic virus have been determined by copying the in vitro polyadenylated RNAs with reverse transcriptase using d(pT8G) as primer and the 2',3'-dideoxynucleoside 5'-triphosphates as specific chain terminators. The terminal sequences of RNAs 3 and 4 were identical; this was expected since hybridization data has shown that the sequence of RNA 4 was present at the 3'-end of RNA 3 (Gould and Symons (1978) Eur. J. Biochem. 91, 269-278). The first 138 residues of RNAs 1 and 2 were identical to those of RNAs 3 and 4 except for one residue in RNA 1 and three residues in RNA 2. From residue 139 to 270 from the 3'-terminus, RNAs 1 and 2 showed, relative to RNAs 3 and 4, a non-homologous region of 33 residues, a homologous region of 40 residues, a partially homologous region of 14 residues which probably extended to about residue 300. There were 11 residues different between RNAs 1 and 2.
92,013
eng
[ "D000818", "D001483", "D002645", "D005260", "D007700", "D008297", "D008970", "D009693", "D010057", "Q000378", "D011061", "Q000302", "D014176", "D012333", "Q000302", "Q000378", "D012194", "D051381", "D012669", "Q000032", "Q000378" ]
[ "Animals", "Base Sequence", "Chickens", "Female", "Kinetics", "Male", "Molecular Weight", "Nucleic Acid Hybridization", "Oviducts", "Poly A", "Protein Biosynthesis", "RNA, Messenger", "RNA-Directed DNA Polymerase", "Rats", "Seminal Vesicles" ]
1979
Nov
Isolation and partial purification of the major abundant class rat seminal vesicle poly(A+)-messenger RNA. Total poly(A(+))-RNA (poly(A(+))-RNA(tot)) was isolated from rat seminal vesicle and its size distribution determined by 70% formamide 5-25% sucrose density analysis. One major peak was resolved in the 10-13 S region and accounted for approximately 35% of the total poly(A(+))-RNA applied. Preparative 1% SDS, 5-20% linear sucrose density gradients also resolved a single major peak in the 11S region (poly(A(+))(11S). Analysis of poly(A(+))-RNA(tot) and poly(A(+))-RNA(11S) under denaturing conditions on 2% agarose gel electrophoresis demonstrated two major components in both poly(A(+))-RNA populations. Size estimations for these components are 620 and 540 NT respectively. (3)H-cDNA was made to both poly(A(+))-RNA(tot) and poly(A(+))-RNA(11S). Back-hybridization of poly(A(+))-RNA(tot) and poly(A(+))-RNA(11S) to their respective (3)H-cDNA revealed a highly abundant class representing 41% and 85% of the sequences in their respective (3)H-cDNA's. The highly abundant class corresponded to 3-5 sequences present in 30,000-50,000 copies/cell. Invitro translation of poly(A(+))-RNA(11S) resulted in two major polypeptides coded for by the 620 NT long and 540 NT long poly(A(+))-RNA respectively.Images