Most human genetic disorders are caused by the expression of ___?
952198
Recessive genetic traits
687997
Causes\n \nX-linked recessive inheritanceThe fragile X syndrome is a genetic disorder caused by mutation of the FMR1 gene on the X chromosome. Mutation at that site is found in 1 out of about every 4000 males and 1 out of about every 6000 females.\n\nNormally, the FMR1 gene contains between 6 and 53 repeats of the CGG codon (trinucleotide repeats). In people with the fragile X syndrome, the FMR1 allele has over 230 repeats of this codon.\n\nExpansion of the CGG repeating codon to such a degree results in a methylation of that portion of the DNA, effectively silencing the expression of the FMR1 protein.\n\nThis methylation of the FMR1 locus in chromosome band Xq27.3 is believed to result in constriction and fragility of the X chromosome at that point, a phenomenon that gave the syndrome its name.\n\nMutation of the FMR1 gene leads to the transcriptional silencing of the fragile X-mental retardation protein, FMRP. In normal individuals, FMRP binds and facilitates the translation of a number of essential neuronal RNAs. In fragile X patients, however, these RNAs are not translated into proteins. The various sequelae of fragile X syndrome .\n\n[edit]\nTransmission of the Fragile X\nThe diagram (right) of X-linked recessive inheritance is not entirely inappropriate but it markedly oversimplifies the situation and does not provide a sufficient foundation for genetic counseling about the fragile X syndrome.\n\nBecause males normally have only one copy of the X chromosome, those males with significant trinucleotide expansion at the FMR1 locus are symptomatic. They are mentally retarded and may show various physical features of the fragile X syndrome.\n\nFemales have two X chromosomes and thus have double the chance of having a working FMR1 allele. Females carrying one X chromosome with an expanded FMR1 gene can have some signs and symptoms of the disorder or be normal.\n\nMales with the fragile X cannot transmit it to any of their sons (since males contribute a Y chromosome, not an X, to their male offspring.)\n\nFemales carrying one copy of the fragile X can transmit it to their sons or daughters. Sons who receive the fragile X are at high risk for mental retardation. Daughters who receive the fragile X may appear normal or they may be mentally retarded, usually to a lesser degree than boys with the syndrome.\n\nIt can begin at birth
1100456
The fragile X syndrome is a genetic disorder caused by mutation of the FMR1 gene on the X chromosome. Mutation at that site is found in 1 out of about every 4000 males and 1 out of about every 6000 females.\n\nNormally, the FMR1 gene contains between 6 and 53 repeats of the CGG codon (trinucleotide repeats). In people with the fragile X syndrome, the FMR1 allele has over 230 repeats of this codon.\n\nExpansion of the CGG repeating codon to such a degree results in a methylation of that portion of the DNA, effectively silencing the expression of the FMR1 protein.\n\nThis methylation of the FMR1 locus in chromosome band Xq27.3 is believed to result in constriction and fragility of the X chromosome at that point, a phenomenon that gave the syndrome its name.\n\nMutation of the FMR1 gene leads to the transcriptional silencing of the fragile X-mental retardation protein, FMRP. In normal individuals, FMRP binds and facilitates the translation of a number of essential neuronal RNAs. In fragile X patients, however, these RNAs are not translated into proteins. The various sequelae of fragile X syndrome .
806888
non-mendelian inheritance can be seen in disorders that are polygenic or mutations that have varying expressivity.
135674
A common abnormality is caused by nondisjunction, the failure of replicated chromosomes to segregate during Anaphase II. A gamete lacking a chromosome cannot produce a viable embryo. Occasionally a gamete with n+1 chromosomes can produce a viable embryo.\n\nSex-chromosome abnormalities(not to mention super-male & super-female) may also be caused by nondisjunction of one or more sex chromosomes. Any combination (up to XXXXY) produces maleness. Males with more than one X are usually underdeveloped and sterile. XXX and XO women are known, although in most cases they are sterile.
1008277
Theories suggesting a psychological cause were originally the most widely accepted, but the majority opinion is now that Asperger syndrome is at least partly genetic.\n\nThe overwhelming majority of available information on Asperger syndrome relates to children; there is currently more conjecture than hard evidence on how it affects adults. It is thought that most people with Asperger syndrome learn to cope with their social impairments later in life.[citation needed] However, there is no "cure" as such, and some people, including prominent clinicians such as Attwood and some of those diagnosed with Asperger's, would strenuously argue that a cure is neither possible nor desirable (see "A gift and a curse" and "Culture" below), mainly pointing out that the syndrome is a hereditary trait and attempts to "cure" or eliminate it would be an example of eugenics. Organizations such as Cure Autism Now disagree; this remains a highly controversial area.\n\nAlthough they are not recognised as often, there are adults with Asperger's. Adults are not as regularly treated, yet they still have similar problems as children. They may find it difficult gaining a job or getting into undergrad or graduate schools because of poor interview skills or a low score on Standardized or Personality tests, due to this they may be more vulnerable to poverty than the general population. If they do get a job they may become victims of bullying or be misunderstood at work. They may also have difficulty finding a life partner and getting married because of poor social skills. Even later in life, many people with Asperger's report a feeling of being unwillingly detached from the world around them. On the other hand there is a large group of Asperger adults who do get married, get a doctorate from a fine university, and hold a job; it just depends on the individual. More research is needed on adults with Asperger's.
285881
There are several including Hemophilia, Down's Syndrome, Huntington's Chorea. The following website gives more info.
667542
Tay Sachs Disease?\nI think thats it...
954706
You know hormones have great effects on your own behavior. Have you ever been very afraid, or angry? We are quite certain the human behavior is probabilistically influenced by heredity. The only argument left among scientist is the proportion of the heredity of behavior.
15786
genetics. human evolution and advancement of science has much to do with it. today, science can play around with our DNA to such an extent as to eliminate dreaded diseases such as cancer from our very genes.
276635
Of the hundreds of causes of dwarfism in humans, most are genetic, and most involve single gene variations that affect the structure or metabolism of bone, cartilage, or connective tissue. This class of disorder is referred to by physicians as skeletal dysplasia. Chondrodystrophy, chondrodysplasia, osteochondrodystrophy are also used (fairly interchangeably) in the medical literature to refer to most of these conditions. In many of these conditions, the bones are the primary affected body part, and the person is otherwise healthy. In many others, the genetic difference affects other body systems, causing unusual features or other major problems. Achondroplasia is one of the most common and perhaps the most easily recognized skeletal dysplasia. It affects approximately 1 in 40,000 children, both males and females, as it is due to a mutation of an autosomal gene.
912386
Fragile X is a serious genetic disorder.  It is caused by mutation of the X chromosome.  The outcome can be significant and debilitating.  It can affect males and females differently.  Males may have enlarged ears, large testicles, long face, and skeletal problems.  This is along with hearing loss, speech issues, and ADD issues as well.  Both will have cognitive delays.  Women have similar physical issues as the men, but usually not as severe.
81465
DISEASES LIKE LEUKEMIA, CANCER & CHILD R BORN WITH PHYSICAL DEFECTS..........
829462
This should keep you busy for hours.....\nhttp://en.wikipedia.org/wiki/List_of_genetic_disorders
995002
Mutations occur frequently, not like in the cartoons, but small changes happen in chromosomes that are not inherited from the mother or the father.  Some of them cause terrible diseases, others may not cause problems at all.
875757
go to google and type in genetic disorders and then take your pick. I thought young kids were supposed to be so computer savy!
1061792
Some genes booze heavily and hibernate.\nWhile the others - ex-pressed!