Would any one plz tell me treatment for metastatic neuroendocrine carcinoma.?
969097
what you are describing is a cancer between the hormonal and nervous system. Below are some treatment therapies:\n\n[edit] Surgery and chemotherapy\nSurgery is the only therapy that can cure GEP-NETs. However, the typical delay in diagnosis, giving the tumor the opportunity to metastasize, makes most GEP-NETs ineligible for surgery (non-resectable).\n\nThere is "no established standard therapy for the liver metastasis of pancreatic endocrine tumors" (Sato et al. 2000, [12]). The most common nonsurgical therapy for all GEP-NETs is chemotherapy, although chemotherapy is reported to be largely ineffective for carcinoids, not particularly durable (long-lasting) for PETs, and inappropriate for PETs of nonpancreatic origin.\n\nWhen chemotherapy fails, the most common therapy, in the United States, is more chemotherapy, with a different set of agents. Some studies have shown that the benefit from one agent is not highly predictive of the benefit from another agent, except that the long-term benefit of any agent is likely to be low.\n\nStrong uptake of somatostatin analogs is a negative indication for chemo.\n\n\n[edit] Symptomatic relief\nThere are two major somatostatin-analog-based targeted therapies. The first of the two therapies provides symptomatic relief for patients with secretory tumors. In effect, somatostatin given subcutaneously or intramuscularly "clogs up" the receptors, blocking the secretion of hormones from the tumor cells. Thus a patient who might otherwise die from severe diarrhea caused by a secretory tumor can gain additional years of life.\n\nSpecific counter-hormones or other hormone-blocking medications are sometimes also used to provide symptomatic relief.\n\n\n[edit] Hormone-delivered radiotherapy\nThe second of the two major somatostatin-analog-based targeted therapies is called peptide receptor radionuclide therapy (PRRT), though we might simply call it hormone-delivered radiotherapy. In this form of radioisotope therapy (RIT), radioactive substances (called radionuclides or radioligands) are chemically conjugated with hormones (peptides or neuroamines); the combination is given intravenously to a patient who has good uptake of the chosen hormone. The tumor cells pull the hormone to them, and the attached radiation kills nearby cells. In patients with strongly overexpressing tumor cells, nearly all the radiation either sticks to the tumors or is excreted in urine. As Rufini et alia say, GEP-NETs "are characterized by the presence of neuroamine uptake mechanisms and/or peptide receptors at the cell membrane, and these features constitute the basis of the clinical use of specific radiolabeled ligands, both for imaging and therapy" (Rufini, Calcagni, and Baum 2006, [13]).\n\nThe use of PRRT for GEP-NETs is similar to the use of iodine-131 as a standard therapy (in use since 1943) for nonmedullary thyroid tumors (which are not GEP-NETs). Thyroid cells (whether normal or neoplastic) tend to be avid for iodine, and nearby cells are killed when iodine-131 is infused into the bloodstream and is soon attracted to thyroid cells. Similarly, overexpressing GEP-NET cells (neoplastic cells only) are avid for somatostatin analogs, and nearby cells are killed when radionuclides attached to somatostatin analogs are infused into the bloodstream and are soon attracted to the tumor cells. In both therapies, hormonal targeting delivers a much higher dose of radiation than external beam radiation could safely deliver.\n\nAs of 2006, PRRT is available in at least dozen medical centers in Europe. In the USA it is FDA-approved, and available at the MD Anderson Cancer Center, but using a radionuclide, indium-111, that is vastly weaker than the lutetium-177 and the even stronger yttrium-90 used on the European continent. In the UK, only the radionuclide metaiodobenzylguanidine (I-MIBG) is licensed (but GEP-NETs are rarely avid for MIBG). PRRT with lutetium or yttrium is nowhere an "approved" t
971227
get the book "natural cures they dont want you to know about" by kevin Trudeau book number 2 it has alot of stuff that you can do.. my grandfather has been doing it and hes had cancer for like 3 years and he stopped his kemo last year and he seems to be doing better with what the book told him to do.. now i am not saying do what the book says and itll go away.. or even dont listen to the doctors but i am just telling you what my granfather did.. please do what you feel comfortable to do..
820948
You might want to read this\n\nhttp://www.patient.co.uk/showdoc/23069180/\n\nthe treatment part is towards the bottom of the page
608944
PLEASE TAKE YOUR HEALTH VERY SERIOUSLY AND SEEK PROFESSIONAL ADVICE RATHER THAN THIS FORUM.  SEEK YOUR PHARMICIST OR PHYICIAN REGARDING THIS.  PLEASE YOU ONLY HAVE ONE LIFE AND IT IS PRECIOUS.
856410
My poor grandfather had prostate cancer, which is supposedly one of the slowest-growing cancers there is.  He was in the hospital for something unrelated, and out of nowhere started getting sicker.  He lost his appetite, and over the course of a couple of days, started having difficulty walking and talking.  \n\nMy grandmother questioned the same thing that you did, so she questioned one of the nurses as to whether his cancer had metastasized.  The nurse more or less brushed her off and said, "No, prostate cancer wouldn't grow that fast."\n\nWell, to make a long story short, he kept getting worse and worse, until finally his lungs and kidneys shut down.  As it turned out, he had developed a secondary, fast-growing cancer that had metastasied all over his body within a matter of weeks.\n\nBy the time this was discovered, he was far too sick for any form of traditional treatment, and we unfortunately lost him very quickly after that.\n\nI certainly hope that this isn't the case with your friend... some of what she's experiencing could be the side effects of the chemotherapy.  Although I've never heard anyone "talking funny" from chemo, I'm certainly not an expert on the subject. \n\nI just wanted to share my story with you, because it still makes us sick that my grandma questioned his prognosis and was told that it couldn't have spread.  I guess we'll always wonder if he could have been helped had they acted sooner.\n\nI certainly don't have any advice for you on how to approach your friend... it's very hard to question others' judgment when it comes to the way they're treating their cancer, especially when you're not the one paying the bills.  I unfortunately know this far too well from experience... I guess all you can do is sit down with her husband by himself and discuss your fears.  It's hard, though, because you don't want to place any undue worry on him.\n\nI don't know how close of a relationship you have with this couple, but if you don't want to worry them directly, is it possible to pull one of her oncologists aside and talk it over with them?  I don't know if she's in the hospital or not, but that might be a good way to go about it.  If you feel like there's nothing you can do without overstepping your bounds, I guess all you can do is hope that the doctors notice what you have... but that's not always the case, either.\n\nSorry if I wasn't more help... at any rate, I wish you the best.  If you're at all religious or spiritual, maybe a prayer for guidance is in order.  If you're not... just listen to your heart, I guess.  :)
955043
Really sorry to hear about your Dad....It depends on the severity of the cancer and the treatments he recieves. \n\nAll the best !!
935887
Sorry about your Mom\nI wish to provide you the most maximum information about the types of diseases and related treatments around the globe, covering patients testimonies and some of the latest experiences of people while treating the disease etc\n\nTREATMENTS\nTypes of Treatments Allopathy, \nand other methods in alternate medicines \n\nSURVIVED PATIENTS TESTIMONIES\nTestimonies / Results\nBy patients after various Treatments\n\nAyurveda Results\nhttp://www.cancer-treat.com\nAyurved + Homoeo Results\nhttp://www.gpinstitute.com\nHomoeo Results\nhttp://news.webindia123.com/news/Articles/Health/20061125/518385.html\nUnani Results\nhttp://www.unani.com/comparison.html\n\nFor Cancer, AIDS & TB\nFREE Treatments & Medicines available at\nhttp://www.actamcproject.com\n\nPATIENT Blogs & Clubs\nInfo about the experiences by the patient or their care taker\nSearch for more Support for the patients here \nwhere? How? http://www.cancer.org \n\nPRECAUTIONS for all?\nBefore and After the Disease etc\n\nCHARITY for CANCER \nhttp://www.57357.com/Default.aspx?tabid=237\n\nAll of the above and much more has to be added to ur pages\nPlease FIND Free website Hosting here before you Buy new website Easily design your own website and host it FREE\nhttp://www.freewebs.com\n\nI do wish to contribute for Domain, Webhosting or Designing etc to encourage you in this GOOD CAUSE\n\nY Q&A is always here to encourage you,\nTAKE IT SERIOUS \nIts about a promise to the MOM\nIn remembrance of ur Mom,
905117
full information leaflet available here\n\nhttp://www.patient.co.uk/showdoc/27000881/
1046883
Is this for curiosity's sake, or a serious medical question? I only ask because in the latter case it's best to get information directly from the doctor treating the disease. I will say, however, that these things depend on a number of variables. First, do you mean "large small cell tumor?" What stage is it in? Has it metastasized (spread to other organs)? How healthy is the patient? How old?\n\nSmall cell carcinoma is a very aggressive cancer, spreading quickly and not always detected at an early stage. However it is also very responsive to radiation and chemotherapy, making it easier to treat once it's found. If the patient is healthy and able to endure the treatment, once they reach the 2 year mark things are looking good.
534273
I would see another Doctor. Synthroid is a common treatment for thyroid conditions, however without further details, Its impossible to say. \n\nAlso have a look at this information:\n\nhttp://search.yahoo.com/search?_adv_prop=web&x=op&ei=UTF-8&fr=fp-top&fr2=op&va=natural+thyroid&va_vt=any&vp_vt=any&vo_vt=any&ve_vt=any&vd=all&vst=0&vf=all&vm=i&fl=0&n=10
537693
I agree with you to a large degree. Personally I believe the tradition treatments, chemo and/or radiation..cause more problems are are ineffective. In alot of cases the patient dies as a result of complications of the treatment, not from the actual disease. Yes, diet...I think an organic diet makes a huge difference, putting more chemicals into a body that is struggling doesnt make a lot of sense. Alot of the meds, even pain meds like morphine, tend to produce angiogenesis in cancer cells and spread the tumors. Im a big believer in the budwig diet and I'm a big believer in meditation and visualisation. I do believe there are alot of other things you can also do to help. For example, biophosponate to stop the spread to bones...blocking the FE+ receptors..cancer cells need iron to divide and multiply, blocking the FE+ receptors deprives them of iron and they cant continue to divide and muliply..there is a chemical in anti-malarial meds that does this. I also strongly believe in Qigong - powerful chinese med to bolster the immune system. Oxidisation treatment, hyperbaric chamber...Dendric cell therapy .. IPT (Insulin Potentiation Therapy), Ultra Violet treatment...there is so much.  Good on you for looking further than the traditional!
133211
I'm not sure about treatment, but for info check out the leukemia and lymphoma society. Also, there are several books written on it, so check your local library. I don't remember the names of any of them, but some of them were pretty easy to understand.
762099
Google L690.......All you can find is that it is a chemotherapy drug.  Haven't seen any images.
1167935
Don't trust me or your doctor but pro-biotics are harmless compared to even an asiprin. Do your own research and discover the truth for yourself. If I told you that Chemo-Therapy was the best thing for your condition, would you believe me? If it is food then it is probably not going to injure you.
202994
Try:\nhttp://www.nlm.nih.gov/medlineplus/ency/article/001177.htm#Treatment
269779
Best thing you can do man. I read abit about that before its amazing the results they had.  Doesnt take years like psycho-therapy and you dont have to deal with malicious anti-depresents in you bloodstream. Best thing you can do, highly recomended.
606876
talk to your doctor for treatment.