I have SLE, currently I was given mabthera, does anyone has used this drug before ?
925076
its a antibody also used in Rheumatoid and some malignancies, should hopefully help you with SLE too, there are lots of hits on yahoo if you want to learn about this drug, good luck
751833
Saead70 How are you dude! I am teacher at Case Western Reserve University in Cleveland, Ohio and this will help you\n\nWe previously produced three congenic strains carrying lupus susceptibility genes (Sle1-Sle3) from the lupus-prone NZM2410 mouse on the C57BL/6 background and characterized their component phenotypes. Sle1 mediates the loss of tolerance to nuclear antigens; Sle2 lowers the activation threshold of B cells; and Sle3 mediates a dysregulation of CD4+ T cells. We have now created a collection of bi- and tricongenic strains with these intervals and assessed the autoimmune phenotypes they elicit in various combinations. Our results indicate that Sle1 is key for the development of fatal lupus. The combination of Sle1 with Sle2, Sle3, or the BXSB-derived autoimmune accelerating gene yaa results in the development of systemic autoimmunity with variably penetrant severe glomerulonephritis culminating in kidney failure. In contrast, two locus combinations of Sle2, Sle3, and yaa failed to mediate fatal disease. These results indicate that the loss of tolerance to chromatin mediated by Sle1 is essential for disease pathogenesis and identify the pathway occupied by Sle1 as a strategic target for therapeutic intervention in systemic lupus erythematosus. The coexpression of Sle1, Sle2, and Sle3 as a B6-triple congenic results in severe systemic autoimmunity and fully penetrant, fatal glomerulonephritis. These results demonstrate the fulfillment of the genetic equivalent of Koch's postulate, where susceptibility loci in a lupus-prone strain have been identified by a genome scan, isolated and functionally characterized by congenic dissection, and finally shown to mediate full disease expression when recombined in a normal genome.\n\n \nTop \nAbstract \nMaterials and Methods \nResults \nDiscussion \nReferences   \nAlthough the effector mechanisms responsible for the clinical features of systemic lupus erythematosus (SLE) have been studied extensively (1), the primary immunological defects responsible for the initiation and progression of disease remain poorly understood. A wealth of data clearly indicates, however, that genetic predisposition is a key element in susceptibility (2, 3). Several mouse models of lupus displaying different phenotypes and genotypes have collectively contributed a great deal toward our understanding of the disease and have led to the identification of more than 20 genomic intervals associated with susceptibility to SLE or SLE-related phenotypes (4–6). In the NZB/NZW-related NZM2410 lupus-prone strain, we have specifically identified the genomic positions of three recessive loci [Sle1, Sle2, and Sle3 on chromosomes (chr) 1, 4, and 7, respectively] that are strongly associated with SLE-susceptibility (7).\n\nAlthough linkage analyses have provided valuable information about the number and locations of susceptibility genes in lupus-prone strains, they have supplied little information about the nature of the component phenotypes each locus contributes, or how they interact to produce the immunopathology characteristic of the susceptible parental strains. We have adopted a congenic dissection approach to address these issues (8). The basic principle of this approach is to convert a polygenic system into a series of monogenic systems in individual congenic strains, each carrying a single susceptibility interval on a resistant genetic background. The component phenotypes expressed in these strains are amenable to genetic and functional analysis as Mendelian traits. The selection process driving the congenic derivation is purely genetic, i.e., a specific genomic segment is transferred from one strain to another (9). We have produced three congenic strains (10), B6.NZMSle1, B6.NZMSle2, and B6.NZMSle3, by moving each susceptibility interval onto the C57BL/6 (B6) background (Table 1) and used these strains to characterize the primary phenotypes associated with the Sle loci (11). \n\nSle1 mediates the loss of
136830
Do not know but I do know how to treat lupus and put it into withdrawl.
715834
I took it but did not get that reaction at all.  Instead, I felt a little weird in the head and kinda shaky.  I stopped taking them because after a few days, it started upsetting my stomach and causing me to have painful BM.  (IF anything, I had more energy).\n\nEveryone reacts differently to medications.  Report your symptoms to your doctor (make sure the doctor gets the info and not the nurse).  You can also go on Medline and type Mobic and it should give you the side effects.  It is a very good anti-inflammatory but does not work for everyone.
700925
First...there is no cure for Lupus but there are alot of charlatins out there that would love to sell you the "cure".\n\nBut yes, it is very possible for you to get pregnant and to do ok.  I would suggest that you are healthly in every other aspect and not starting this out in a flare.  I would also line up a perinatologist.\n\nAlthough a lupus pregnancy is considered high risk, most women with lupus carry their babies safely to the end of their pregnancy. Women with lupus have a higher rate of miscarriage and premature births compared with the general population. In addition, women who have antiphospholipid antibodies are at a greater risk of miscarriage in the second trimester because of their increased risk of blood clotting in the placenta. Lupus patients with a history of kidney disease have a higher risk of preeclampsia (hypertension with a buildup of excess watery fluid in cells or tissues of the body). Pregnancy counseling and planning before pregnancy are important. Ideally, a woman should have no signs or symptoms of lupus and be taking no medications for at least 6 months before she becomes pregnant.\n\nPregnancy counseling and planning before pregnancy are important.\n\nSome women may experience a mild to moderate flare during or after their pregnancy; others do not. Pregnant women with lupus, especially those taking corticosteroids, also are more likely to develop high blood pressure, diabetes, hyperglycemia (high blood sugar), and kidney complications, so regular care and good nutrition during pregnancy are essential. It is also advisable to have access to a neonatal (newborn) intensive care unit at the time of delivery in case the baby requires special medical attention.\n\nI have both Lupus and APS.  I often ask myself these same questions.  Is it fair to have a baby and be sick or possibly die on them.  And being that both you and your mom have Lupus there is a strong familia trait in your family...chances are your baby will develop it.  So, no kids here.  Chances are I will adopt.  I have too many medications that I would have to stop.\n\nAnd since APS is often triggered in Lupus patients during pregnancy, I will give you that page too.
451934
I am a caretaker for my mom.  I got it because she has had lupus all her life and had a stroke that almost killed her.
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I've been taking prednisone for quite a while for my rheumatoid arthritis.  It helps with the pain a lot, but after taking it for a period of time, you body may build an immunity to it.  Try taking aleve for a few weeks, then switch back to prednisone.  Aleves active ingredient is Naproxen.  It's an anti inflamatory that works well with any kind of joint or bone pain.  after that, switch back.  You won't want to increase your dose of prednisone without your doctors consent.  If I were you though, ask your doctor if there is anything else that you can take instead of prednisone.  As I said before, it works great for pain, but there are a lot of side affects that can be associated with it such as moonface, necrosis, and even diabetes.  \nP.S. Its not going to be easy to ween you off that stuff though.  You cant suddenly quit taking it.  If you do, you may experience flare ups with your pain.  Ask your doctor for information on how to get off it.
357495
http://www.mayoclinic.com/health/lupus/DS00115
1070638
Hey Sam, I have had crohn's for 15 + yrs. I know how you feel. Those who have never had this disease will not. I have tried probiotics, aloe vera juice, fish oil, jordan rubins program, you name it its been through my system (not always pleasantly). I am currently on Remicade and have been for over a year. It has put me into remission. I also believe it is an auto immune disease whether caused by man or environment I'm not sure. I have had many days where I feel like crap & often have deep thoughts of this disease. I do know hereditary is a factor as I can prove by most of my relation having ms, ra, lupus & crohn's. Do you have a good dr? If not find one even one who specializes in homeopathy can help. I wish you luck in finding a miracle we all are looking for!
609017
Have you been tested for lupus?
231990
Lupus, Crohn's Disease, and some other diseases mimic eachother.  MS isn't the worst thing that could happen to you.  I speak from experience, because I have MS.
338808
ask doc about marinol. it's a tch pill, and you WILL eat lol. my friend was on it, because she has lupus, and wasn't eating. marinol fixed her quick. and it's not addictive, if you use it correctly.\nit is hard to get though.
1049943
Systemic lupus erythematosus (SLE or lupus) is a chronic, potentially debilitating or fatal autoimmune disease in which the immune system attacks the body’s cells and tissue, resulting in inflammation and tissue damage. SLE can affect any part of the body, but often harms the heart, joints (rheumatological), skin, lungs, blood vessels and brain/nervous system. Lupus is treatable, mainly with immunosuppression, though there is currently no cure for it.\n\nThe standard treatment, for decades, has been a limited group of drugs (primarily corticosteroids and chemotherapy drugs). Research into more modern treatments has recently begun and is accelerated by genetic discoveries, especially mapping of the human genome. SLE is known as "the great imitator", as its symptoms often mimic other illnesses and because they come and go unpredictably. Diagnosis can be elusive, with patients sometimes suffering unexplained symptoms and untreated SLE for years. Increased awareness and education about lupus since the 1960s has helped many more patients get an accurate diagnosis and made it possible to estimate the number of people with lupus. Lupus was previously believed to be a rare disease. In the United States alone, an estimated 270,000 to 1.5 million people have lupus, making it more common than cystic fibrosis or cerebral palsy. The disease primarily affects young women, although men can be diagnosed with lupus. World-wide, a conservative estimate states that over 5 million people have lupus.\n\nSLE was called lupus (Latin for "wolf"), perhaps due to a crude similarity between the facial rash that some lupus patients develop, and a wolf's face, although various explanations have been proposed.\n\nI hope this helps and good luck!! you're in my prayers
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HELL YES. \n\nMy sister suffers from Lupus. She was in Kaiser for 6 months last year. She was taking sleeping pills, and 5 Dilodins (HEAVY pain meds) per day just to get thru it (which, incidentally, are extremely addictive). Since she's discovered medicinal marijuna, she hasnt used sleeping pills, and takes one Dilodin every OTHER day....\n\nWhen she told the Kaiser doctors, they freaked out and told her to quit...and Rx'd EVEN MORE MEDICATIONS! Weed is natural and grow on trees...but they want her to stuff herself full of medications that are hard on her liver. Freakin western medicine...
439079
I just looked at a book about Lupus and the minerals. We have disease from a lcak of minerals in our body. Unrefined Sea has all of the minerals of human blood. If you take a tablespoon of sea salt in a glass of distilled water three times a day, your insomnia may end. To provide good flora for your body, you might try drinking three more glasse of water and add a tablespoon of apple cider vinegar and cinnamon.\nhttp://curezone.com/blogs/f.asp?f=179\nhttp://curezone.com/blogs/f.asp?f=172&t=31942\n\nYou might also try eating one Brazil Nut each day TO HELP REMOVE TOXIC METALS\nhttp://owen.curezone.com/nutrition/seleniumdeficiency.html\n and eat as much cilantro in your diet for elimination of mercury and lead.\n\nIf you are consuming any kind of dairy you might consider quiting and switch to almond milk.\nhttp://curezone.com/blogs/f.asp?f=125&t=31963
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I've never heard of this but maybe someone on this lupus forum has:\n\nhttp://curezone.com/forums/f.asp?f=52\n\np.s.  lots of people on this forum have cured their Lupus!\n\nhttp://curezone.com/dis/1.asp?C0=216
758455
I have been taking Sinement for 5 years for restless leg syndrome, its the same med as Ropinirole, but was okayed for treatment of Parkinson's, that is why they now use the name of Ropinirole for the use of RLS. I'm not sure about the deficiency of dopamine relationship to RLS ( i my self am not depressed, and do not have the other symptoms related to deficiency in dopamine, However, I do suffer migraines and I understand that lack of magnesium may be responsible for RLS and migraines. I only started taking 500mg of magnesium to see if the severity RLS and migraines lessen......i will give it a month. I would not worry over much about the lack of dopamine, wait for results and talk with your doctor. good luck