what is the effect of high uric acid ?
350256
In short, High uric acid has 2 important effects. \nOne, inflamation of joints which causes pain, redness and limitation of movements.\nTwo, damage the kidneys by forming small crystals which injure the kidney and may cause Renal Failure after long time. It may also cause Uric acid kidney stones. \n\nI tried to make it simple!
917368
No, Allopurinol is not a pain killer and the ingredients are not the same.  Allopurinol is used to treat chronic gout (a form of arthritis). It works by preventing the formation of uric acid (a product of the metabolism of protein that's present in the blood and released in the urine). Blocking uric acid production helps prevent gout attacks and the formation of kidney stones or other kidney problems.
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Gout can be hereditary and it can be triggered by all sorts of foods and drinks.  My husband takes a daily dose of allopurinol, and as long as he takes it faithfully, the gout stays away.  When it hits, it's horrible.  It's so painful that he can't stand even the weight of a sheet over the affected area.  My sympathies are with anyone who suffers from gout.  It can be treated, but relief isn't instant.\n\nThis is one of the few types of arthritis where the cause is known. It results from deposits of needle-like crystals of uric acid in the connective tissue, joint spaces, or both. Normally this is a byproduct of the breakdown of purines or waste products in the body. Normally uric acid breaks down in the blood and is eliminated in urine. When the body increases its production of uric acid or if the kidneys do not eliminate enough of it from the body, levels build up. This is called hyperuricemia. Hyperuricemia is not a disease and is not dangerous. However, if excess uric acid crystals form as a result of hyperuricemia, gout can develop.\n\nFoods that may trigger gout include beer and other alcoholic beverages, anchovies, sardines (in oil), fish roes, herring, yeast, organ meats (e.g., liver, kidneys), legumes (e.g., dried beans, peas, and soybeans), meat extracts, consommé, gravies, mushrooms, spinach, asparagus, cauliflower, and poultry. Weight loss can help reduce uric acid levels in those people that are overweight.\n\nNonsteroidal anti-inflammatory drugs (NSAIDs) block prostaglandins, the substances that dilate blood vessels and cause inflammation and pain. They are taken orally at their highest safe dosage as long as symptoms persist and for three or four days after. There are dozens of NSAIDs. Indomethacin (Indocin) is the usual choice.\n\nColchicine, a derivative of the autumn crocus, has been used to treat gout for thousands of years. This drug relieves the pain and swelling and can help prevent future attacks. Although highly effective, it is no longer the first treatment choice due to the potential for unpleasant side effects.\n\nCorticosteroids may be used if NSAIDs are not tolerated.\n\nAllopurinol (Lopurin, Zyloprim) blocks uric acid production and is the drug most often used in long-term treatment for older patients and those with high levels of excreted uric acid.
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serious side effects, \n\nan allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); \nan irregular or fast heartbeat; \nchest pains or very high blood pressure (blurred vision, severe headache, flushing); \nunusual behavior or confusion; or \nliver damage (yellowing of the skin or eyes, nausea, abdominal pain or discomfort, unusual bleeding or bruising, severe fatigue).
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Uric acid and glutathione are both anti-oxidants.  Neuronal death in MS (and likely Alzheimers, etc) has been linked to higher levels of damaging reactive oxygen species, and cell culture studies indicate that antioxidants can protect neurons from this damage-and some clinical studies in humans show beneficial effects (though some also show no effect).  Glutathione depletion has been linked to cases of MS, leading to the hypothesis that this lack of intrinsic antioxidant may lead to greater neuronal death due to oxidative stress.  In other studies, serum uric acid levels were found to be reduced in MS patients, leading to the same conclusion noted for glutathione.  In one study, reduced uric acid was correlated to increased peroxynitrite, a toxic reactive compound associated with oxydative stress.  Thus, some suspect that MS patients either have reduced antioxidants leading to neuronal damage, or have reduced antioxidants because of depletion by oxidating compounds generated by the disease-and because of this, a lot of current study is looking at ways to boost antioxidants to either protect against MS or to slow it's progression.
287102
check out side effects \nprobably heartburn
885838
There are three lines of treatment. The first is simply control of pain, for which your physician may prescribe an analgesic other than aspirin. The second treatment is control of inflammation caused by uric-acid crystals. For this your physician may prescribe an anti-inflammatory drug. Alfalfa is a good source of minerals and other nutrients that help to reduce serum uric acid. Take 2,000 to 3,000 milligrams daily in tablet or capsule form.\n\n  When an attack of gout strikes, eat only raw fruits and vegetables for two weeks. Juices are best.\n  Maintain a diet low in purines at all times. Purines are organic compounds that contribute to uric acid formation.\n\nConsume plenty of quality water. Fluid intake promotes the excretion of uric acid.\n\nAvoid rich foods such as cakes and pies. Leave white flour and sugar products out of your diet.
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Urine pH as measured by urinalysis has a normal range of about 4.5-8 with a pH of 6 being the average. Neutral pH is 7. Anything having a lower pH is acidic and anything with a higher pH is basic. \nUrine is actually a fairly good growth medium for bacteria and is sometimes used in labs for this pupose. However urine with a lower pH (more acidic) has been found to inhibit the growth of bacteria. \nUrine that is high in ammonia on the other hand with its higher pH (more alkaline or basic) has been found to impede the bodies immune responce to a UTI. In fact Proteus species of bacteria which is a common cause of UTIs produces a substance called urease which breaks down uric acid (an end product of nitrogen metabolism found in urine) into ammonia and carbon dioxide, thus causing the urine to become more basic. The ability of Proteus of produce urease increases its ability to cause pylonephritis (infection of the kidney as opposed to the blatter or ureters).\nTaking substances that will alter the pH of your urine however may have unforseen side effects. The pH of the urine helps determine what is and what is not filtered out of the blood by the kidney. Also altering the pH will have an effect of the formation of kidney stones. Certain particles will become "un-dissolved" at a higher pH and some at a lower pH. If enough of the particles come out of solution, you will get kidney stones. In fact the Proteus bacteria that cause the urine to become more basic are associated with an increase in kidney stones.\nI general however pH has very little to do with get or not getting a UTI. The urinary tract from the distal urethra up is mostly sterile and the few bacteria that do get into the urinary tract are usually flushed out when you urinate. Some bacteria however such as E. coli have molecules on thier outer membrane that can adhere to the urinary tract lining. It can do this reguardless of pH and pH in general has little effect on E. coli which is what causes about 85% of UTIs not contracted in a hospital. E. coli is found in the digestive tract and most UTIs are caused when the E. coli finds its way into the urinary tract. While in the digestive tract the E. coli has had to endure the extremely acidic pH of the stomach and the very basic pH of the small intestine.\nMost bacteria that cause UTIs are from the digestive tract. Often they are aided in migration to the urethra by sexual intercourse. The use of spermicides is associated with an increase in UTIs because the protective bacteria of the vagina are killed by the spermicide and this leave the vagina vulnerable to colinization by UTI causing bacteria.\nAlso some women are genetically predisposed to UTI because they have more adhesion molecules on their vaginal walls.\nCranberry juice is helpful in preventing UTI. Studies have shown that cranberry juice inhibits the ability of bacteria to adhere to the urinary tract.\nIf recurrent UTIs are a problem you may want to speak to you doctor about methanamine. It is used to prevent UTIs especially those caused by E. coli which is the most common cause of UTIs.
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It is a metabolic disease causing slow growth, enlarged liver, gout, kidney failure and chronic low blood sugar.  New treatments have greatly imporved the outcome for people with this disease.  With early diagnosis and treatment people who have it now live to adulthood.\n\nThe websites attached should help you.
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Hello I am a med and dietetics student. Please take this as an OPINION only and not as medical advice as I am not an MD or RD yet. High amounts of uric acid can be absorbed by drinking cherry juice concentrate. It is a little pricey, about $17 for a small bottle but it does help. Stay away from tea as this is acidic. Drinking large amounts of water won't really help. The only thing it will do is flush your system of toxins and keep you hydrated. Have you ever had the gout? If you do not know what this is, it is a form of artheritis where uric acid builds up in your body. The pain is severe and often takes place in the largest digit of the body such as a thumb or big toe. If you have, then talk to your doctor about going on rx colchicine and and ibuprofen. If you have not suffered from the gout, then I reccommend the cherry juice. Talk with your doctor before hand to make sure that it will not interfere with any medications you are taking or health conditions you might have. Aside from the tea, stay away from green vegetables, dairy and red meats as these are also high in uric acid. Eat starchy foods such as potatoes, pasta and rice. Hope this helped and good luck!
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What is gout? \n\nGout is a form of arthritis marked by sudden attacks of painful, inflamed joints. It is characterized by pain, swelling, redness, and warmth (inflammation) as well as stiffness in a joint or joints. Without treatment, gout attacks tend to recur and may cause severe damage to joints, tendons, and other tissues. Gout is most common in men.1\n\nWhat causes gout? \n\nGout is caused by too much uric acid in the blood (hyperuricemia). Hyperuricemia usually does no harm, and most people with high levels of uric acid in the blood never develop gout. When uric acid levels in the blood are too high, uric acid may form crystals that accumulate in the joints. The exact cause of hyperuricemia sometimes goes undiscovered, although inherited factors (genes) seem to play a role. Gout can seem to flare up without specific cause or can be brought on by factors such as being overweight, eating meats and seafood that are high in chemicals called purines, taking certain medications (especially aspirin and diuretics), and drinking too much alcohol.
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The most common side effects of colchicine involve the stomach and bowel and are dose related. These include nausea, vomiting, abdominal pain, and diarrhea. One of the most worrisome side effects of colchicine is that it can damage the bone marrow causing severe anemia and seriously low white blood counts, thereby increasing the risk of infections. All patients taking colchicine long-term require blood count monitoring. Colchicine can also cause hair loss, weakness, and nerve irritation.... gout is at least twice as effective at lowering uric acid levels as the standard drug allopurinol. ..                . Febuxostat has a different chemical structure than colchicine.
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Best remedy is always the natural remedy - lots of WATER and limit eating the purine (uric acid) sources!\n\nWhy? Gout (gouty arthritis) is caused by increased uric acid in the blood which may be due to several reasons:\n\nOne is increased intake of purines that contributes to the uric acid in the blood when eventually metabolized, Second is when the person has a deficiency in his kidneys that the accumulated uric acid in the blood cannot eventually get out of your system.  Another reason is when the person has hypercatabolism or increased degradation of body tissues that could also lead to increased uric acid production and concentration in the blood.\nSo what now if you have an increased uric acid concentration in the blood?  High uric acid levels in the blood without enough water/fluids, or without the proper excretory function of the kidneys will leave/deposit these uric acids in the joints and eventually forming them into uric acid salts.  These salts when formed in the joints makes it swollen or painful, and thus a gouty attack.\n\nThere are also other factors that lead to higher retention of uric acid in the blood like cigarette smoking, excessive alcohol drinking, intake of caffeine, fatty and salty foods.  All of these tends to increase uric acid concentrations in the blood, not because they are the source of it, but they tend to minimize its excretion from the kidneys.\n\nTo minimize gouty attacks, bear in mind the following:\n\n1)  Drink a lot of water - at least 2 liters per day to flush out extra wastes in the blood.  Don't worry, water is zero (0) calories so it won't make you gain weight!\n\n2) Limit intake of high purine containing foods: internal organs, dried beans, nuts & seeds, lentils, mushrooms, anchovies, sardines, small types of fishes.\n\n3) Avoid the foods that tend to minimize the uric acid excretion from the blood: fats & oils (in excesive amounts), chicken skin & wings - breast is best, alcohol, coffee (caffeine), smoking.\n\n4) Avoid eating salty foods as they tend to promote water retention in the blood, minimizing excretion of the fluids including uric acid accumulated in the blood.\n\nThese simple things when followed will surely help you out with your gout.\n\nAlso, maybe you should try to visit your doctor and let your kidneys be checked, as sometimes (as in sometimes, not always!), having a gouty attack could also be the effect or symptom of a malfunctioning kidney/s.  Who knows, prevention is better than cure, and kidney malfunction/(death) is irreversible.\n\nThere are also some other drug remedies for gout which is typically used for acute (immediate or for the moment) attacks.\n\nFor those people who are sure they don't have kidney malfunction, they can use Non-Steroidal Anti Inflammatory Drugs.  These drugs tend to reduce the swelling and pain as fast remedy.  Drug list include: Indomethacin, Diclofenac or Ketorolac.\n\nColchicine may also be used for acute attacks.\n\nFor prolonged use, you may use Allupurinol 100mg once daily for 2 weeks.  Dose may be increased to 300mg once daily after the first 2 weeks.\n\nThough, the best remedy is still the first that i have offered: WATER & Diet Therapy.  This will give you a less costly remedy, and more enjoyable life without the medications.
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there really isnt a side effect of intaking too much vitamin ..your body can only absorb and process so much of it and then you excreet the rest in your urine...so you just waste it...they say the bodies max is 140 milligrams per day
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Hi There\n\nHere are some ideas on how to heal your condition.\n\nCauses of Gout\nGout is caused by excessive accumulation of uric acid in the tissues. The underlying cause of uric acid accumulation is unknown, yet research has found that it can basically be attributed to metabolic or kidney problems. Increased production of uric acid may be the result of metabolic enzyme defects, certain types of chronic anemia, or other complex conditions. Dehydration and kidney disease can cause poor clearance of uric acid from the body.\n\nProper diet, nutrition, and metabolic balance all play crucial roles in the prevention and treatment of this disease. The conception of gout as a condition of affluence is tenuous, but a heavy diet, particularly organ meats that increase amount of uric acid, and alcohol consumption, can hinder the removal of uric acid by the kidneys.\n\nAlthough most people initiate a gout attack through poor lifestyle choices (obesity, rich foods, alcohol), 10%-15% of gout patients have attacks due to a metabolic problem, such as a deficiency of enzymes (xanthine oxidase) and purine imbalances. Purines come from certain foods (meat products, especially liver and other organ meats, sausages and other processed meats, anchovies, crab, shrimp, milk, eggs, and many beans, including soy), but are also normally present, in the form of DNA and RNA in the cells. Purines are broken down into uric acid, which is then normally excreted through the urine.\n\nMedications, including aspirin and diuretics, can cause gout by putting extra stress on the kidneys; these drugs cause 25% of new gout cases. Kidney stones and other kidney problems are present in 90% of gout sufferers, because urate crystals also accumulate in the kidneys.\n\nQuick Action Plan for Gout\n\n\n1. The goal of diet for those with gout is to reduce the production of uric acid to normal levels. Cherries, and all rich colored berries, such as blueberries, are recommended. Consume half a pound of fresh or unsweetened frozen cherries per day for a period of three to six weeks as a healing protocol. \n\n2. Organic cherry juice is especially good for gout, as are many of the new "magic juices" such as Goji, Acai and Noni juice, puree or powder. Pomegranate fruit extracts have been shown to be effective as well. \n\n3. Eliminate alcohol consumption, which both increases uric acid production and reduces uric acid excretion in the kidneys. Gout sufferers should also maintain a low-purine diet, which completely omits organ meats, shellfish, yeast (brewer's and baker's), herring, sardines, mackerel, and anchovies. \n Intake of dried legumes, spinach, asparagus, fish, poultry, and mushrooms, should also be curtailed. Refined carbohydrates and saturated fats are best kept to a minimum. \n\n4. Diet and Nutrition: Diet and nutrition are the primary means of treating gout naturally. Dietary treatment for gout sufferers is intended to reduce the production of uric acid to normal levels. Cherries, hawthorn berries, blueberries, and other dark red or blue berries are rich sources of compounds that favorably affect collagen metabolism and reduce inflammation of joints. Bioflavonoids found in black cherries have been used to reduce uric acid levels and decrease tissue destruction associated with gout. Gout sufferers could consume half a pound of fresh or unsweetened frozen cherries per day for a period of three to six weeks as a healing protocol.\n\nAlso strongly recommended for arthritic conditions are Noni juice, acai berries, and the whole or juiced goji or wolfberries. Pomegranate fruit extracts have been shown to block enzymes that contribute to cartilage degradation. As of 2006, the natural foods marketplace has been flooded with an exciting range of new products that are high in Bioflavonoids, anti inflammatory properties, and loaded with anti-oxidants. Look for Acai, goji and Noni puree, juice or powder that you can add to your diet.\n\nGout patients should eli
71328
Gout is a form of arthritis that developes when there is a build up of uric acid in the blood. When the uric acid levels get high enough, it collects in the joints. The joint that is usually first and most severely affected is the big toe joint. As this uric acid collects in the toe joint, it forms crystals in the shape of a needle. These needle like crystals cause a stabbing pain , sometimes excruciating pain, plus swelling. The affected toe is like an inside out pin cushion. OUCH!!! \n\n95% of the Gout sufferers are men over 30. It is rare, but it does attack women also. Gout is closely related to the foods you eat. The natural approach to Gout would be to change your diet and increase your fluid intake. \n\nThere are foods that cause an increase in uric acid and they should be greatly curtailed from the diet. These foods are: \n\nanchovies, \nasparagus, \nherring, \nmeats & gravies, \nmushrooms, \nmussels, \nsardines, \nand alcoholic beverages, \nfried foods. \nThey should also try to avoid rich cakes and pies. \nSome studies have shown a vitamin deficiency of vitamin B5, vitamin A, and vitamin E contribute to the disease process of Gout. \n\nThere are foods that can neutralize the uric acid, so these can be eaten freely. They are: \napple cider vinegar,\ncherries, \ncherry juice, \ncelery, strawberries \navocados. \nIt is necessary to increase your water intake also as this will help flush the uric acid out. Herbs that help to neutralize the uric acid are alfalfa, burdock, hyssop and juniper. Alfalfa is the stongest of the mentioned herbs and the first choice. There are prescription drugs available from your doctor but please ask about the mild to serious side effects of these drugs.       \n* The information in this article should not replace the advice of your medical practitioner. \n\nLucinda Jenkins is an LPNHC and is the owner of Glenbrook Farms Herbs and Copyright © 2000, Lucinda Jenkins
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The crystal in urine can appear because of many factors, such as: over-saturated concentration of its parts, pH, crystallization inhibitors etc.\nThere are a lot of crystal types:\n1. of uric acid (in acid urine, it helps convert uric salts, soluble, in uric acid, insoluble); with a rhomboid shape, they could appear in patients with gout.\n2. of calcium phosphate or calcium oxide: the calcium oxide ones don't depend on the urine pH, meanwhile the calcium phosphate crystals grow in an alkaline urine. Risk factors: low ingest of liquids and calcium, high ingest of salt and proteins.\n3. crystals of magnesium phosphate: when the urine's pH increases, the solubility of the phosphate reduces