While tournament favourites France host Ireland and Scotland face Wales in Cardiff, much attention will be on whether England can rebound from their shock loss to Wales last week.
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Can England rebound from their shock loss?
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Edwards likes Barbados chances against champions
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Montpellier looking to close the gap
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Spotlight will be on out of form players:
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Hughes ready to return
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Wales showed character, says captain Ashley Williams
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Stars could face Guinea Bissau
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Edwards looking to strengthen squad
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Irish stars playing in Dublin.
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France giving uk a good kicking - Clegg
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England consider two spinners for World Cup clash with India
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Jermain Defoe 5/1 to start against the USA
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UK and Ireland 'need each other'
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Yeovil Town look to bounce back
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France outclasses Ireland 26-22
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Wales beat France 16-6 in Six Nations
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Leinster & Munster could meet in final