does calcium channel blockers affect the liver?
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Hepatic injury from calcium channel blockers is usually mild and reversible, but rare symptomatic and severe instances have been reported. Agents most clearly linked to liver injury are verapamil, diltiazem, amlodipine and nifedipine, probably because these agents have been most widely used.
607257
While all approved calcium channel blockers inhibit the L-type calcium channel on cells, they are divided into two major categories based upon their predominant physiologic effects: the dihydropyridines, which are predominantly vasodilators and generally have limited chronotropic and inotropic effects, and the non- ...
513009
Abstract. Calcium channel or entry blockers (CEBs) exert important vascular and tubular effects on the kidney. These renal effects include an enhancement of glomerular filtration rate (GFR), renal blood flow (RBF), and electrolyte excretion.
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Calcium channel blockers reduce blood pressure by widening your blood vessels. Common examples are amlodipine, felodipine and nifedipine. Other medicines, such as diltiazem and verapamil, are also available. Possible side effects include headaches, swollen ankles and constipation.
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Calcium Channel Blockers: Calcium channel blockers decrease smooth-muscle contractility in the bladder. This causes urinary retention and, accordingly, leads to overflow incontinence.
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Calcium channel blockers start working within 2 – 4 hours of taking the first dose, but it can take 3 – 4 weeks for the full effects to kick in.
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In very rare cases, statins may cause liver problems or a potentially life-threatening breakdown in muscle cells. However, the most common side effect is muscle pain and cramping.
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Calcium channel blockers work on certain types of cells, like those found in the muscles of the heart and the smooth muscles of the blood vessel walls, decreasing the force of contraction of the muscle. Calcium channel blockers do this by preventing (blocking) calcium from entering the cells.
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The idiosyncratic liver injury due to tizanidine ranges from hepatitis with jaundice to acute liver failure leading to death. Chronic injury and vanishing bile duct syndrome have not been reported after tizanidine therapy. Recurrence on re-exposure has been reported and rechallenge should be avoided.
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Many drugs can affect the way the liver functions, damage it, or do both. (See also Drugs and the Liver.) Some drugs, such as statins (used to treat high cholesterol levels), can increase the levels of liver enzymes and cause liver damage (usually minor) but no symptoms.
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The calcium channel blockers, verapamil and diltiazem, should generally be avoided in patients with CHF, as their negative inotropic effects may exacerbate the disease.
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The cases of clinically apparent liver injury due to lisinopril are idiosyncratic and likely due to a reaction to a minor metabolite. Lisinopril has minimal hepatic metabolism.
200401
The present study proposes a mechanism by which calcium channel antagonists may induce gingival hyperplasia. The calcium antagonist induces blockage of the aldosterone synthesis in zona glomerulosa of the adrenal cortex since this pathway is calcium-dependent, cyclic nucleotide-independent.
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Calcium channel blockers They're used as part of the treatment of conditions such as high blood pressure (hypertension) and coronary heart disease. Grapefruit juice interacts with some calcium channel blockers and increases the level of the medicine in your blood.
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High-dose insulin has become accepted as therapy in calcium channel blocker (CCB) toxicity refractory to standard vasopressor therapy. Hyperglycemia may occur in CCB toxicity, as calcium channel blockade inhibits insulin release.
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Nifedipine lowers your blood pressure and makes it easier for your heart to pump blood around your body. The most common side effects include headache, flushing, constipation, feeling tired and swollen ankles. These usually improve after a few days of treatment.
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Like fast-response action potentials, changes in the membrane conductance to calcium and potassium ions alter slow-response action potentials. Calcium-channel blockers reduce the slope of phase 4, thereby decreasing the rate of spontaneous depolarization, which reduces the rate of pacemaker firing.