what are estrogen receptor antagonists?
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In Wikidata. Antiestrogens, also known as estrogen antagonists or estrogen blockers, are a class of drugs which prevent estrogens like estradiol from mediating their biological effects in the body. They act by blocking the estrogen receptor (ER) and/or inhibiting or suppressing estrogen production.
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Describes cells that have a receptor protein that binds the hormone estrogen. Cancer cells that are estrogen receptor positive may need estrogen to grow, and may stop growing or die when treated with substances that block the binding and actions of estrogen. Also called ER positive.
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Hormone receptor-negative (or hormone-negative) breast cancers have neither estrogen nor progesterone receptors. Treatment with hormone therapy drugs is not helpful for these cancers. These cancers tend to grow faster than hormone receptor-positive cancers.
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XTANDI is an androgen receptor inhibitor. Androgens are a group of hormones that includes testosterone. Androgen receptor inhibitors interfere with the connection between androgens and androgen receptors. This can help slow cancer cell growth.
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Anastrozole is used to treat breast cancer in women after menopause. Some breast cancers are made to grow faster by a natural hormone called estrogen. Anastrozole decreases the amount of estrogen the body makes and helps to slow or reverse the growth of these breast cancers.
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Femhrt (norethindrone acetate, ethinyl estradiol) is a combination of the female hormones estrogen and progesterone used to treat symptoms of menopause such as hot flashes, and vaginal dryness, burning, and irritation.
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Faslodex is a liquid given as an injection into a muscle. Arimidex (chemical name: anastrozole) is an aromatase inhibitor, another type of hormonal therapy. Aromatase inhibitors work by blocking the enzyme aromatase, which turns androgen hormones into small amounts of estrogen in the body.
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Aromatase inhibitors tend to cause fewer serious side effects than tamoxifen, such as blood clots, stroke, and endometrial cancer. But aromatase inhibitors can cause more heart problems, more bone loss (osteoporosis), and more broken bones than tamoxifen, at least for the first few years of treatment.
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Ibrance is used with certain hormone therapies for breast cancer. Hormone therapies stop estrogen, a hormone your body produces, from making the cancer cells grow and multiply. These therapies include drugs such as letrozole (Femara) and fulvestrant (Faslodex). Ibrance helps make these therapies more effective.
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Are Arimidex and Nolvadex the Same Thing? Arimidex (anastrozole) and Nolvadex (tamoxifen citrate) are used to treat breast cancer. Arimidex is used in postmenopausal women and is often given to women whose cancer has progressed even after taking tamoxifen (Nolvadex, Soltamox).
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Tamoxifen (Nolvadex) has been used for over 40 years to treat hormone-receptor positive early, locally advanced and metastatic breast cancers. Learn about tamoxifen and other hormone therapies (endocrine therapies) for metastatic breast cancer.
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Antiandrogens, also known as androgen antagonists or testosterone blockers, are a class of drugs that prevent androgens like testosterone and dihydrotestosterone (DHT) from mediating their biological effects in the body.
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Conjugated estrogens are a medicine that contains a mixture of estrogen hormones. It is used to treat moderate to severe hot flashes, changes in and around the vagina, and other symptoms of menopause or low amounts of estrogen (hypoestrogenism).
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Are all aromatase inhibitors the same? ... The third-generation aromatase inhibitors (AIs) anastrozole, exemestane, and letrozole offer new treatment options, although their efficacy has not been compared directly in randomized, double-blind, controlled trials in any breast cancer treatment setting.
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Arimidex belongs to a class of drugs called aromatase inhibitors, which limit the amount of estrogen the body produces in postmenopausal women. Arimidex works by preventing the conversion of steroids made by the adrenal gland into estrogen.
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Estrogens are hormones that are important for sexual and reproductive development, mainly in women. They are also referred to as female sex hormones. The term "estrogen" refers to all of the chemically similar hormones in this group, which are estrone, estradiol (primary in women of reproductive age) and estriol.
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Ibrance works by stopping cancer cells from dividing and growing. Ibrance is a pill taken by mouth. Faslodex is an estrogen receptor downregulator. Faslodex sits in the estrogen receptor in breast cells so the cell can't receive estrogen's signals to grow and multiply.