what can sickle cell cause?
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Abnormal versions of beta-globin can distort red blood cells into a sickle shape. The sickle-shaped red blood cells die prematurely, which can lead to anemia. Sometimes the inflexible, sickle-shaped cells get stuck in small blood vessels and can cause serious medical complications.
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The infection stops new blood cells from being made, leading to anemia. Stroke. Sickle cells can block blood vessels in the brain, cutting off oxygen and causing a stroke. In people without sickle cell disease, stroke is much more common in older people.
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Sickle cell disease (SCD), or sickle cell anemia, is a group of genetic conditions, resulting from the inheritance of a mutated form of the gene coding for the β globulin chain of the hemoglobin molecule, which causes malformation of red blood cells (RBCs) in their deoxygenated state.
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Sickle cell anemia is an inherited disease that affects red blood cells with an abnormal version of hemoglobin, the protein that carries oxygen throughout the body. The altered hemoglobin is known as hemoglobin S, or sickle hemoglobin, because it causes normally oval-shaped red blood cells to assume a sickle shape.
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Causes of fatigue Sickled blood cells have trouble traveling through the smallest blood vessels, which means that muscles and tissues are not getting the oxygen they need. Sickle cell anemia also causes chronic pain and inflammation, which can interfere with sleep, leading to fatigue.
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Having sickle cell disease means a lifelong battle against the health problems it can cause, such as pain, infections, anemia, and stroke. But many people are able to have a very good quality of life by learning to manage the disease.
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One of the affected organs is the liver. Sickle cell disease and its treatment through blood transfusion can lead to significant liver damage. This disease also can cause the liver to regrow abnormally after damage. This can cause high blood pressure in the liver.
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While beta thalassemia is caused by a defect in the beta-globin gene, controlling the production of the beta-globin chains of hemoglobin, sickle cell disease is caused by a defect in hemoglobin itself with the presence of abnormal hemoglobin S.
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White blood cells and platelets are usually high in sickle cell disease. Too many white blood cells (WBCs) and platelets can cause damage to the blood vessels. Also, high WBCs and platelets are associated with more severe complications of sickle cell disease such as stroke and acute chest syndrome.
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Sickle cell disease is a group of disorders that affects hemoglobin, the molecule in red blood cells that delivers oxygen to cells throughout the body. People with this disease have atypical hemoglobin molecules called hemoglobin S, which can distort red blood cells into a sickle, or crescent, shape.
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SCD is a well-known genetic disorder that results in dramatic alteration and function of red blood cells (RBCs). Sickle RBCs can also obstruct the vasculature; activate leukocytes, platelets, and endothelial cells; and exacerbate inflammation.
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Periodic episodes of pain, called pain crises, are a major symptom of sickle cell anemia. Pain develops when sickle-shaped red blood cells block blood flow through tiny blood vessels to your chest, abdomen and joints. Pain can also occur in your bones.
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Early signs and symptoms of sickle cell disease include swelling of the hands and feet; symptoms of anemia, including fatigue, or extreme tiredness; and jaundice. Over time, sickle cell disease can lead to complications such as infections, delayed growth, and episodes of pain, called pain crises.
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Additionally, in individuals with the genetic defect, the painful sickle cell crisis can be precipitated by certain medical and environmental factors including infection, bleeding, exposure to cold weather, leg ulcers, and blockage of the blood vessels.
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Background. Patients with sickle cell disease (SCD), an inherited haemoglobinopathy, have increased risk of malaria, at least in part due to impaired splenic function.
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In sickle cell anemia, the abnormal hemoglobin causes red blood cells to become rigid, sticky and misshapen. Both mother and father must pass the defective form of the gene for a child to be affected.
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Sickle cells that block blood flow to organs deprive the affected organs of blood and oxygen. In sickle cell anemia, blood is also chronically low in oxygen. This lack of oxygen-rich blood can damage nerves and organs, including your kidneys, liver and spleen, and can be fatal. Blindness.