can cmml turn into aml?
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CMML can develop into an acute myeloid leukaemia (AML) if the number of blast cells in your blood rises above 20%. Doctors call this transformation. Transformation happens in between 15 and 30 out of every 100 people with CMML (15 to 30%). This might happen after a few months or after several years.
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In about 1 in 3 patients, MDS can progress to a rapidly growing cancer of bone marrow cells called acute myeloid leukemia (AML). In the past, MDS was sometimes referred to as pre-leukemia or smoldering leukemia.
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In about two-thirds of cases, CML transforms into a disease resembling acute myeloid leukaemia (AML). The remainder transforms into a disease resembling acute lymphoblastic leukaemia (ALL). Occasionally, the blast cells are said to be undifferentiated or mixed.
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Cash management bill (CMB) is a short-term security sold by the U.S. Department of the Treasury. The maturity on a CMB can range from a few days to three months. The money raised through these issues is used by the Treasury to meet any temporary cash shortfalls and provide emergency funding.
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CMML is different to chronic myeloid leukaemia (CML). CML affects the myeloid cells in the blood and bone marrow, while CMML affects a specific myeloid cell called a monocyte, which helps to fight infections.
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This is known as the accelerated phase of CML. During this time a proportion of blast cells may start to increase in your bone marrow and circulating blood. Eventually, CML transforms into a rapidly progressing disease resembling acute leukaemia. This is known as the blast phase or blast crisis.
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Blast phase In about two-thirds of cases, CML transforms into a disease resembling acute myeloid leukaemia (AML). The remainder transforms into a disease resembling acute lymphoblastic leukaemia (ALL). Occasionally, the blast cells are said to be undifferentiated or mixed.
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In patients with leukemia, cell growth goes "haywire," and there is a rapid growth of abnormal white blood cells. So inside the bone marrow, blood cells are beginning to multiply and divide into red blood cells, white blood cells and platelets.
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During this process, the cells become either lymphocytes (a kind of white blood cell) or other blood-forming cells, which are types of myeloid cells. Myeloid cells can develop into red blood cells, white blood cells (other than lymphocytes), or platelets. These myeloid cells are the ones that are abnormal in AML.
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Progression to leukemia About one-third of people with MDS will develop AML, which is cancer of the bone marrow. For this reason, doctors sometimes refer to MDS as preleukemia. People with more advanced MDS have a much higher risk of AML.
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The only curative option for CMML remains allogeneic stem cell transplantation. When transplantation is excluded, CMML is stratified into myelodysplastic (white blood cell count <13 × 109/L) and proliferative (white blood cell count ≥13 × 109/L) CMML.