how do calcium channel blockers cause edema?
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Calcium channel blocker (CCB)‐related edema is quite common in clinical practice and can effectively deter a clinician from continued prescription of these drugs. Its etiology relates to a decrease in arteriolar resistance that goes unmatched in the venous circulation.
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Calcium channel blockers do not affect mineralization of the bone, nor do they increase the risk for osteoporosis. One group found that people on calcium channel blockers may have a slightly higher risk of fractures; however, that was thought to be due to an increased number of falls, especially in the elderly.
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swelling, also called edema, most often in the feet, ankles, wrists, and face. discomfort in the body, causing cramping, headache, and stomach bloating. high blood pressure caused by excess fluid in the bloodstream. shortness of breath caused by extra fluid entering your lungs and reducing your ability to breathe ...
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Before using ibuprofen, tell your doctor if you also use verapamil. The combination may cause your blood pressure to increase. You may need a dose adjustment or your blood pressure checked more often. Also, if you are already taking the combination and stop taking ibuprofen, your blood pressure may decrease.
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Calcium channel blockers slow the entry of calcium into these muscles, which reduces the strength of the contractions and lowers the blood pressure. Common side effects of calcium channel blockers include: tiredness. flushing.
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Amlodipine is a calcium channel blocker. Amlodipine relaxes (widens) blood vessels and improves blood flow. Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention. Olmesartan is an angiotensin II receptor antagonist.
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Amlodipine causes vasodilatation of the arterioles and not venules causing increased capillary hydrostatic pressures leading to edema. Schematic diagram showing mechanism of cilnidipine. It causes vasodilatation of the arterioles venules by decreasing sympathetic mediated vasoconstriction by N type calcium channels.
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Swollen ankles can also be a side effect of some blood pressure medicines, in particular calcium channel blockers. These medicines make your small blood vessels open wider and, in some people, this can cause more fluid to leak out of the blood vessels into the tissues.
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Edema is swelling caused by excess fluid trapped in your body's tissues. Although edema can affect any part of your body, you may notice it more in your hands, arms, feet, ankles and legs.
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Calcium channel blockers are prescription medications that relax blood vessels and increase the supply of blood and oxygen to the heart while also reducing the heart's workload.
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Calcium channel blockers are associated with slightly fewer strokes and slightly more myocardial infarctions compared with beta-blockers or diuretics. No significant differences in total or cardiovascular mortality between the classes of medications were noted in this meta-analysis.
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Using dilTIAZem and metoprolol together may lead to increased side effects. This can cause fatigue, headache, fainting, swelling of the extremities, weight gain, shortness of breath, chest pain, increased or decreased heartbeat, or irregular heartbeat.
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Blood pressure drugs The blood pressure medications known as calcium channel blockers and beta blockers can provoke heartburn by relaxing the lower esophageal sphincter, which can allow stomach acid to seep up into the esophagus.
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Calcium channel blockers are prescription medications that relax blood vessels and increase the supply of blood and oxygen to the heart while also reducing the heart's workload. Examples of calcium channel blockers include: Amlodipine (Norvasc) Bepridil (Vascor)
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If you have high blood pressure, your medical doctor may prescribe calcium channel blockers to help control it. However, that can have a side effect of sore, swollen gums that can be disturbing if you don't expect it. Calcium channel blockers can cause gingival (gum) overgrowth, said Dr.
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All blood pressure medications lower your blood pressure, but drugs like beta-blockers and calcium channel blockers also lower heart rate. And some, like diuretics, lower fluid levels in the body and can decrease edema (swelling).
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Blood pressure drugs The blood pressure medications known as calcium channel blockers and beta blockers can provoke heartburn by relaxing the lower esophageal sphincter, which can allow stomach acid to seep up into the esophagus. If this happens to you, ask your doctor about alternatives.