are bone marrow transplants dangerous for the donor?
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Bone marrow donation The most serious risk associated with donating bone marrow involves the use and effects of anesthesia during surgery. After the surgery, you might feel tired or weak and have trouble walking for a few days. The area where the bone marrow was taken out might feel sore for a few days.
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The case fatality rate of severe aplastic anemia is high although treatment, whether by allogeneic stem-cell transplantation or immunosuppression, has dramatically improved the prognosis over the last 25 years, and more than 75% of patients can now be expected to have long term survival with either therapy.
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It is safe to occasionally donate plasma. ... Measures are taken to ensure donor safety, such as allowing donors to give plasma no more than once or twice per week. The risks of a donation visit are relatively mild—bruising, nausea, and dizziness are some of the occasional side effects.
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It can occur anywhere from 3 months to more than a year following a stem cell transplant. Cases of chronic GVHD can range from mild to severe and can be long-lasting and debilitating. Chronic GVHD can lead to skin problems and hair loss.
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Your bone marrow transplant occurs after you complete the conditioning process. On the day of your transplant, stem cells are infused into your body through your central line. The transplant infusion is painless. You'll be awake during the procedure.
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Some GvHD can be a good thing because it means that your new immune system is working and is likely to be attacking any remaining or returning disease. This can be referred to as 'graft versus leukaemia effect' or 'graft versus tumour effect'. However, too much GvHD can cause unwanted complications and side effects.
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If you have an allogeneic bone marrow transplant, your donor's transplant-related medical care may be paid by your insurance company.
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Although a bone marrow transplant is the only treatment that can cure CML, it is used less often now. This is because bone marrow transplants have a lot of side effects, while TKIs are very effective for CML and have fewer side effects.
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Stem Cell Transplant for Multiple Myeloma. In a stem cell transplant, the patient gets high-dose chemotherapy to kill the cells in the bone marrow. Then the patient receives new, healthy blood-forming stem cells.
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For example, a genetic disorder associated with a heart defect might be treated with surgery to repair the defect or with a heart transplant. Conditions that are characterized by defective blood cell formation, such as sickle cell disease, can sometimes be treated with a bone marrow transplant.
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GVHD occurs when the donor's T cells (the graft) view the patient's healthy cells (the host) as foreign, and attack and damage them. Graft-versus-host disease can be mild, moderate or severe. In some cases, it can be life-threatening.
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There are two types of hematopoietic cell transplantation, autologous and allogeneic. An autologous hematopoietic cell transplant uses a patient's own bone marrow or blood. An allogeneic hematopoietic cell transplant uses a donor's bone marrow or blood.
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['fatigue.', 'night sweats.', 'recurrent fevers.', 'weight loss.', 'itching.', 'bone pain, if your bone marrow is affected.', 'loss of appetite.', 'abdominal pain.']
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['Low blood cell counts. You will have low blood cells counts after a stem cell transplant. ... ', 'Graft-versus-host disease (GVHD) ... ', 'Veno-occlusive disease (VOD) ... ', 'Digestive system problems. ... ', 'Skin and hair problems. ... ', 'Pain. ... ', 'Kidney problems. ... ', 'Lung problems.']
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Diabetes should not put you at any greater risk of feeling faint or nauseous while donating, regardless of whether you have Type 1 or Type 2 diabetes. As long as your diabetes is well-managed and under control, you can donate blood.
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Although aplastic anaemia is not a malignant disease (cancer) it can be very serious, especially if the bone marrow is severely affected and there are very few blood cells left in circulation.
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In stem cell transplants, stem cells replace cells damaged by chemotherapy or disease or serve as a way for the donor's immune system to fight some types of cancer and blood-related diseases, such as leukemia, lymphoma, neuroblastoma and multiple myeloma. These transplants use adult stem cells or umbilical cord blood.