is aleve hard on kidneys?
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NSAIDS, or nonsteroidal anti-inflammatory drugs like ibuprofen (Advil, Motrin) and naproxen (Aleve), lead the list for drugs that cause kidney damage because of their widespread use.
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Naproxen sodium, the active ingredient in Aleve, may cause a severe allergic reaction, especially in people allergic to aspirin or other NSAIDs.
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Patients with mild to moderate renal impairment should be kept under surveillance, since the use of NSAIDs may result in deterioration of renal function. The lowest effective dose should be used and renal function monitored regularly. Effects on renal function are usually reversible on withdrawal of Aceclofenac.
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NSAIDs (e.g. Advil, Aleve and Motrin) While these medications are safe for people, even one or two pills can cause serious harm to a pet. Dogs, cats, birds and other small mammals (ferrets, gerbils and hamsters) may develop serious stomach and intestinal ulcers as well as kidney failure.
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Check with your doctor to be sure you can use these medicines safely, particularly if you have kidney disease. Heavy or long-term use of some of these medicines, such as ibuprofen, naproxen, and higher dose aspirin, can cause chronic kidney disease known as chronic interstitial nephritis.
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Upset stomach/antacid medications. This group of over-the-counter medications can disrupt the body's electrolyte balance if you have chronic kidney disease. Check with your doctor to see if these are safe for you to use.
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Taking NSAIDs with olmesartan can increase your risk of kidney damage. Your risk may be higher if you're a senior, take a diuretic, are dehydrated, or already have poor kidney function. Also, NSAIDs may decrease the effect of olmesartan. This means that it may not work as well to lower your blood pressure.
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In general, anti-histamines do not cause kidney problems. Some, such as diphenhydramine (Benadryl) can cause retention of urine in your bladder. Others such as Claritin and Zyrtec are generally very safe.
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For people with kidney disease: Avoid taking this drug if you have severe kidney disease or if you receive dialysis. Your kidneys may have trouble removing the drug from your body. This could lead to a buildup of the drug and increase your risk of side effects.
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Ibuprofen and other NSAIDs block prostaglandins, natural body chemicals that normally dilate blood vessels leading to the kidneys. Blocking prostaglandins may lead to decreased blood flow to the kidneys, which means a lack of oxygen to keep the kidneys alive. That can cause acute kidney injury.
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What to avoid. If your kidney function is less than 50%, avoid painkillers containing aspirin or ibuprofen (unless a doctor specifically prescribes them for you). They can worsen the function of damaged kidneys. Ibuprofen should also be avoided if you're taking anti-rejection medicines after a kidney transplant.
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Proton pump inhibitors (PPIs) and histamine receptor-2 (H2) blockers, commonly used to reduce gastric acid production, can increase the risk of developing kidney stones and chronic kidney disease (CKD), according to research presented at ASN Kidney Week 2016 in Chicago, IL.
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NSAIDs may cause an increased risk of sudden kidney failure and even progressive kidney damage.
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The first mechanism of acute kidney injury (AKI) from NSAIDs is due to reduced renal plasma flow caused by a decrease in prostaglandins, which regulate vasodilation at the glomerular level.
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Implications: Levetiracetam is a widely used drug that has been reported to be generally tolerable and effective; however, it has the potential to negatively affect renal function.
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Heavy or long-term use of some of these medicines, such as ibuprofen, naproxen, and higher dose aspirin, can cause chronic kidney disease known as chronic interstitial nephritis.
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When unopposed, this may lead to acute tubular necrosis and acute renal failure. NSAIDs also produce interstitial nephritis with or without nephrotic syndrome secondary to minimal change disease. Although this presents as acute renal failure, it can progress in some cases to chronic renal failure.