can abdominal aortic aneurysms be hereditary?
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Abdominal aortic aneurysm (AAA) is thought to be a multifactorial condition, meaning that one or more genes likely interact with environmental factors to cause the condition. In some cases, it may occur as part of an inherited syndrome . Having a family history of AAA increases the risk of developing the condition.
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Some genetic changes are very rare while others are common in the population. The genetic changes, also called mutations, that cause thoracic aortic aneurysms and dissections to be inherited, or run in families, are very rare.
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Chronic high blood pressure may stress the aortic tissue, making it more susceptible to tearing. You can also be born with a condition associated with a weakened and enlarged aorta, such as Marfan syndrome, bicuspid aortic valve or other rarer conditions associated with weakening of the walls of the blood vessels.
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Overview of Aortic Aneurysms. Aneurysms are abnormal dilations of arteries caused by weakening of the arterial wall. Common causes include hypertension, atherosclerosis, infection, trauma, and hereditary or acquired connective tissue disorders (eg, Marfan syndrome, Ehlers-Danlos syndrome).
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Emerging evidence suggests high prevalence of abdominal aortic aneurysm (AAA) among patients with coronary disease.
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An abdominal aortic aneurysm (AAA) is a bulge or swelling in the aorta, the main blood vessel that runs from the heart down through the chest and tummy. An AAA can be dangerous if it is not spotted early on. It can get bigger over time and could burst (rupture), causing life-threatening bleeding.
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The main risk factors are age older than 65 years, male sex, and smoking history. Other risk factors include a family history of abdominal aortic aneurysm, coronary artery disease, hypertension, peripheral artery disease, and previous myocardial infarction.
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No environmental risk factors have been identified for neurological AVM. AVM does not usually run in families, but somewhere on the order of 5% of AVMs may be due to autosomal dominant inheritance of a genetic mutation, most commonly hereditary hemorrhagic telangiectasia or the capillary malformation-AVM syndrome.
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The layers of the aortic wall can also separate (aortic dissection). This produces severe, tearing pain in the chest, back or abdomen. The potential for rupture is the most serious risk associated with an aortic aneurysm. A ruptured aortic aneurysm can cause life-threatening internal bleeding and/or a stroke.
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Approximately 5 to 10 percent of colon cancer is hereditary. The major hereditary colon cancer syndromes are Lynch syndrome (previously known as Hereditary Non-Polyposis Colorectal Cancer or HNPCC) and Familial Adenomatous Polyposis (FAP). Other genes have also been implicated in hereditary colon cancer risk.
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Abdominal aortic aneurysm (also known as AAA, pronounced "triple-a") is a localized dilatation (ballooning) of the abdominal aorta exceeding the normal diameter by more than 50 percent.
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Less frequent causes of AAA include Marfan syndrome, Ehlers-Danlos syndrome, and collagen-vascular diseases. In fewer than 5% of cases, AAA is caused by mycotic aneurysm of hematogenous origin. In these cases, local invasion of the intima and media gives rise to abscess formation and aneurysmal dilation of the vessel.
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An aortic aneurysm is an enlargement (dilatation) of the aorta to greater than 1.5 times normal size. They usually cause no symptoms except when ruptured. Occasionally, there may be abdominal, back, or leg pain. They are most commonly located in the abdominal aorta, but can also be located in the thoracic aorta.
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Rupture of abdominal aortic aneurysm (AAA) can be prevented by elective surgical repair, but because most AAA never rupture,1 elective repair is reserved for patients at high risk of rupture.
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Although the gastrointestinal complications that occur secondary to repair of an aortic abdominal aneurysm (AAA) are uncommon they are associated with a significant increase in patient morbidity and mortality and therefore they warrant discussion.
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It is estimated that an abdominal aortic aneurysm that is over 5.5 cm in diameter will rupture within one year in about 3 to 6 out of 100 men. That's why surgery is often recommended.
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Background— Obesity is associated with occlusive artery disease but is not considered a risk factor for abdominal aortic aneurysm (AAA).