can nsaids cause kidney damage?
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Heavy or long-term use of some of these medicines, such as ibuprofen, naproxen, and higher dose aspirin, can cause chronic kidney disease known as chronic interstitial nephritis.
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Some NSAIDs are available over the counter. This includes different brands of ibuprofen, naproxen sodium and ketoprofen. NSAIDs are usually safe for occasional use when taken as directed, but if you have known decreased kidney function, they should be avoided.
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Drugs that may cause interstitial nephritis include penicillins, cephalosporins, sulfonamides, thiazide diuretics, furosemide, NSAIDs and rifampicin. There are a number of drugs that cause direct toxicity to the renal tubules (acute tubular necrosis) - eg, aminoglycosides, amphotericin and ciclosporin.
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Combining fosinopril or other ACE inhibitors with nonsteroidal anti-inflammatory drugs (NSAIDs) in patients who are elderly, volume-depleted (including those on diuretic therapy), or with poor kidney function may result in reduced kidney function, including kidney failure. These effects usually are reversible.
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Drug-induced hypertension associated with NSAIDs is due to the renal effects of these drugs. Specifically, NSAIDs cause dose-related increases in sodium and water retention. This effect is also seen with COX-2 selective agents, such as celecoxib.
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NSAIDs have been reported to cause renal papillary necrosis with subsequent chronic interstitial nephritis, which can present with hematuria. This is generally a problem of long-term use, and how it occurs is unclear. However, the connection has clearly been demonstrated and is well documented in the literature.
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Administration of NSAIDs during the latter part of pregnancy may cause premature closure of the fetal ductus arteriosus, fetal renal impairment, inhibition of platelet aggregation, and delay labor and delivery. There are no adequate and well controlled studies of diclofenac or other NSAIDs in pregnant women.
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Non-steroidal Anti-inflammatory Drugs (NSAIDs) However, NSAIDs can make your body retain fluid and decrease the function of your kidneys. This may cause your blood pressure to rise even higher, putting greater stress on your heart and kidneys.
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Many medicines can cause acute kidney injury (which used to be called acute renal failure), such as: Antibiotics. These include aminoglycosides, cephalosporins, amphotericin B, bacitracin, and vancomycin.
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When taken as directed, regular use of aspirin does not seem to increase the risk of kidney disease in people who have normal kidney function. However, taking doses that are too large (usually more than six or eight tablets a day) may temporarily- and possibly permanently- reduce kidney function.
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By blocking the Cox-1 enzyme and disrupting the production of prostaglandins in the stomach, NSAIDs can cause ulcers and bleeding. Some NSAIDs have less effect on prostaglandins in the stomach than others, and, therefore, may have a lower risk of causing ulcers, but the increased risk of ulcers still exists.
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Long-term effects Regular use of ibuprofen may eventually cause: kidney and liver damage. bleeding in the stomach and bowels. increased risk of heart attack.
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Certain pain and anti-inflammatory medications can cause you to retain water, creating kidney problems and increasing your blood pressure. Examples include: Indomethacin (Indocin, others) Acetaminophen (Tylenol, others)
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NSAIDS, or nonsteroidal anti-inflammatory drugs like ibuprofen (Advil, Motrin) and naproxen (Aleve), lead the list for drugs that cause kidney damage because of their widespread use.
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Further, prescription NSAIDs have been associated with improvements in nocturia and other urinary symptoms in clinical investigations (9–13). In contrast, 2 large studies of men reported associations between NSAID use and increased risk of acute urinary retention (7), nocturia, and benign prostatic hyperplasia (14).
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Swelling of the inside of your kidney can cause damage, and, if left untreated, can cause serious health problems. Using PPIs may increase the risk of developing acute interstitial nephritis. If caught early, the condition can be treated and leave no signs of damage to your kidneys.
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Follow your dialysis schedule. Do not take aspirin, acetaminophen (Tylenol), ibuprofen (Advil, Motrin), naproxen (Aleve), or similar medicines, unless your doctor tells you to. These medicines may make chronic kidney disease worse.