do muscle relaxers affect kidneys?
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Of all the drugs used in anesthesia, muscle relaxants are among the most affected by renal failure. The uremic state is associated with a variety of derangements which predispose for adverse drug reactions.
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Muscle relaxants increase risk of respiratory complications. Muscle relaxants are a necessary part of anesthesia during certain major operations. However, studies have hinted at respiratory risks connected with these drugs.
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Because muscle relaxers are total body relaxants, they typically induce grogginess or sleepiness. As a result, it is not safe to drive or make important decisions while taking muscle relaxers. Muscle relaxers are often suggested for evening use due to their sedative effect.
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For people with decreased kidney function: Talk with your doctor about whether tizanidine is safe for you. If you take this drug, your doctor may give you a lower dose. Also, your doctor will watch for buildup of too much tizanidine in your body. Symptoms can include dry mouth, dizziness, or drowsiness.
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Check with your doctor right away if you have a fever, joint pain, skin rash, swelling of the body, feet, or ankles, or unusual weight gain after receiving this medicine. These could be symptoms of a serious kidney problem called acute interstitial nephritis.
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In addition, calcium channel blockers appear to have a positive effect on renal addition, calcium channel blockers appear to have a positive effect on renal haemodynamic function in the setting of diabetes mellitus; prospective trials have also demonstrated reductions in urinary protein excretion in these patients.
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Your doctor should check your kidney function while you're taking this medication. If your kidney function gets worse, you may need to stop taking this drug. For people with liver disease: Bumetanide can worsen the symptoms of the liver condition hepatic coma. If you have this condition, you shouldn't take this drug.
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Check with your doctor right away if you have a decreased urine output, confusion, dizziness, nausea, rapid weight gain, swelling of the face, ankles, or hands, or unusual tiredness or weakness after receiving the medicine. These may be symptoms of a serious kidney problem.
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Tramadol immediate-release tablet: If you have kidney problems or a history of kidney disease, you may not be able to clear this drug from your body well. This may increase the levels of tramadol in your body and cause more side effects.
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Spironolactone may worsen kidney function in patients with low to no salt in their body or in those who take other blood pressure medicines (eg, ARB, ACE inhibitor). Talk to your doctor if you have concerns about this.
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When You Might Need a Muscle Relaxer Muscle relaxants are ideally prescribed for acute rather than chronic pain. They may be an option if pain is preventing you from getting enough sleep. Because muscle relaxants cause drowsiness, they can help you get rest when you take them at night.
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Non steroidal anti-inflammatory drugs (NSAIDs) Taking creatine with these pain relievers may increase the risk of kidney damage. NSAIDs include ibuprofen (Motrin, Advil) and naproxen (Aleve).
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Exposure to any NSAID may cause acute kidney injury—and older age and pre-existing kidney problems are big risk factors. The risk for kidney damage is similar among all NSAIDs, so naproxen is neither better nor worse on the kidney than ibuprofen (Motrin, Advil).
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Various classes of antibiotics can harm the kidneys in different ways. Aminoglycosides such as tobramycin can cause toxicity in “renal tubular cells,” which are more sensitive to the toxic effects of drugs because their role in kidney filtration exposes them to high levels of toxins.
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Diuretics. Water pills like hydrochlorothiazide and furosemide, used for high blood pressure and edema, can cause dehydration and can also lead to swelling and inflammation of the kidneys.
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NSAIDs are safe for the liver, but can cause a problem with kidney function that is reversible if you stop taking them. Generally, they are safe, but the kidney problems are worth paying attention to.
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Potential adverse effects from the long-term use of skeletal muscle relaxants include sedation, addictive potential, and hepatotoxicity. Evidence for acute treatment for each of these drugs is less than a month.