are bisphosphonates indicated for osteopenia?
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All bisphosphonates are equally effective in fracture risk reduction. However, when compared to placebo, zoledronate has the highest superiority among all bisphosphonates in providing the highest risk reduction for vertebral fractures [25].
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parathyroid hormone (PTH) into the blood. PTH modulates calcium and phosphate homeostasis, as well as bone physiology. PTH has effects antagonistic to those of calcitonin by increasing blood calcium levels by stimulating osteoclasts to break down bone and release calcium.
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['Alendronate (Fosamax)', 'Risedronate (Actonel)', 'Ibandronate (Boniva)', 'Zoledronic acid (Reclast)']
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ZOLEDRONIC ACID (Reclast) Zoledronic acid is a bisphosphonate prescribed to prevent or treat osteoporosis or Paget's disease. Unlike other common bisphosphonates that are taken by mouth, Reclast bypasses the stomach because it is an infusion into the bloodstream. Bone is a living tissue constantly being remodeled.
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Bisphosphonates bind to the surfaces of the bones and slow down the bone resorping action of the osteoclasts (bone-eroding cells). This allows the osteoblasts (bone-building cells) to work more effectively.
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Osteoporosis is a condition that affects bones, making them less dense, more fragile and prone to fractures. Some people have a higher risk of developing osteoporosis than others. Also, certain bones in the body are more likely than others to become weakened by osteoporosis and fracture.
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Pamidronate is also used along with cancer chemotherapy to treat bone damage caused by multiple myeloma (cancer that begins in the plasma cells [a type of white blood cell that produces substances needed to fight infection]) or by breast cancer that has spread to the bones.
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Bisphosphonates include alendronate (Binosto, Fosamax), ibandronate (Boniva), risedronate (Actonel, Atelvia) and zoledronic acid (Reclast, Zometa). These are effective at lowering the risk of broken bones, which can lead to pain and disability and increase the risk of death.
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Disorders that decrease calcium absorption. Pancreatitis. Certain drugs, including rifampin (an antibiotic), antiseizure drugs (such as phenytoin and phenobarbital), bisphosphonates (such as alendronate, ibandronate, risedronate, and zoledronic acid), calcitonin, chloroquine, corticosteroids, and plicamycin.
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Bisphosphonates were approved for equine use about five years ago to treat horses with symptoms of navicular syndrome, a common, nagging foot pain in older horses. Before the drugs were approved for horses in the U.S., they were used in Europe and veterinarians could legally import them to treat American horses.
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Zoledronic acid (Zometa) is not cancer chemotherapy, and it will not slow or stop the spread of cancer. However, it can be used to treat bone disease in patients who have cancer. Zoledronic acid is in a class of medications called bisphosphonates.
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To date, the consensus is that there has been no proven risk of increased cardiovascular risk with intake of calcium supplements. Other studies have examined the risk of damage to jaw tissue with the use of bisphosphonates, one type of medication commonly used to treat osteoporosis. The risk is real, but rare.
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Bisphosphonates are the most common medications prescribed for osteoporosis treatment. These include: Alendronate (Fosamax) Risedronate (Actonel)
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Bisphosphonates slow the rate that bone is broken down in your body. This maintains bone density and reduces your risk of a broken bone. There are a number of different bisphosphonates, including: alendronic acid.
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Fosamax (alendronate) is a first-choice treatment for osteoporosis, but taking it can be a hassle. Prevents bone loss and lowers your risk of invasive breast cancer. Evista (raloxifene) helps to reduce bone loss and lower the risk of breast cancer in post-menopausal women, but it can cause blood clots.
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As bisphosphonates have a mode of action that interferes with the bone resorption by osteoclasts, they can have side effects in dental treatment, including inhibited tooth movement, impaired bone healing, and induced osteonecrosis in the maxilla and the mandible.
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Treating osteoporosis means stopping the bone loss and rebuilding bone to prevent breaks. Healthy lifestyle choices such as proper diet, exercise, and medications can help prevent further bone loss and reduce the risk of fractures.