is amitriptyline a black box warning?
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Amitriptyline is a Tricyclic antidepressant that is FDA approved for the {{{indicationType}}} of depression. There is a Black Box Warning for this drug as shown here. Common adverse reactions include weight gain, constipation, xerostomia, dizziness, headache, somnolence, blurred vision.
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About amitriptyline for depression Amitriptyline is an antidepressant medicine. It's used to treat low mood and depression. This medicine is only available on prescription.
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Amitriptyline is available as tablets or syrup, taken daily. As it has a sedative effect and may make you drowsy, it's usually taken an hour or two before bedtime (but no later than 8 pm).
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Symptoms that have been reported in individuals who are believed to be undergoing withdrawal associated with discontinuing amitriptyline include: Dizziness and headaches. Other physical symptoms, such as nausea, vomiting, appetite loss, diarrhea, muscle aches, aching joints, fever, chills, and sweating.
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Amitriptyline is currently only available in the United States in generic forms, although it was once marketed under the brand name Elavil. It is not a controlled substance listed by the United States Drug Enforcement Administration (DEA), but it does require a prescription from a physician.
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A multicenter case-control study has shown that in the elderly the consumption of fluoxetine was significantly associated with an excess risk of syncope and orthostatic hypotension [59]. A significant blood pressure lowering effect of fluoxetine was reported in DOCA-hypertensive rats [60].
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Amitriptyline can cause mild and transient serum enzyme elevations and is rare cause of clinically apparent acute cholestatic liver injury.
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['amitriptyline.', 'amoxapine.', 'clomipramine (Anafranil)', 'desipramine (Norpramin)', 'doxepin.', 'imipramine (Tofranil, Tofranil-PM)', 'nortriptyline (Pamelor)', 'paroxetine (Brisdelle, Paxil, Paxil CR, Pexeva)']
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The main aim of lower-dose amitriptyline is to relieve pain, relax muscles and improve sleep, but it may also help reduce any anxiety or depression resulting from the pain. Low-dose amitriptyline alone won't be enough to treat severe depression.
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Black box warnings, also called boxed warnings, are required by the U.S. Food and Drug Administration for certain medications that carry serious safety risks. Often these warnings communicate potential rare but dangerous side effects, or they may be used to communicate important instructions for safe use of the drug.
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Never take Wellbutrin if you have a known allergy to bupropion. You should contact emergency services immediately if you begin to experience allergic symptoms such as rash, swelling, hives, itching, and difficulty breathing.
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Amitriptyline is generally not recommended in pregnancy or while breastfeeding. Your doctor will only prescribe amitriptyline for your pain while you're pregnant or breastfeeding if the benefits of taking the medicine outweigh the risks.
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By raising your serotonin levels, amitriptyline should change your body's reaction to pain. The low dose won't treat depression, but it should reduce your pain, relax your muscles and improve your sleep. It's safe to be prescribed to adults or children.
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Tricyclic antidepressants The TCA assays have historically had a high rate of false positives. Drugs and/or metabolites described at or prior to the year 2000 as causing false-positive TCA results include carbamazepine (14) and cyclobenzaprine (15).
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About amitriptyline for pain Amitriptyline is a medicine used to treat pain. It's especially good for nerve pain such as back pain and neuralgia. It can also help prevent migraine attacks.
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Though the medication can still be sold and used, a black box warning alerts doctors and patients to potentially dangerous problems. Nonsteroidal anti-inflammatory drugs (NSAIDs), such as nabumetone, may increase risk of blood clots, heart attack, or stroke.
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Amitriptyline is still available under its generic name. It belongs to the wider class of drugs called tricyclic antidepressants.