grapefruit juice interferes with what medications?
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Here are examples of some types of drugs that grapefruit juice can cause problems with (interact): Some statin drugs to lower cholesterol, such as Zocor (simvastatin) and Lipitor (atorvastatin). Some drugs that treat high blood pressure, such as Procardia and Adalat CC (both nifedipine).
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Potential drug interactions More than 85 drugs interact with grapefruit and some closely related citrus juices — like Seville oranges, pomelos, and tangelos. That's because chemicals in grapefruit known as furanocoumarins inhibit CYP3A4, in a similar fashion as CBD. The result is a slowed metabolization of medications.
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The co-administration of omeprazole and grapefruit juice decreases the formation of omeprazole sulfone (mediated by CYP3A4) but does not inhibit the formation of 5-hydroxyomeprazole, which is mediated by CYP2C19. Grapefruit juice may inhibit the metabolism of pimozide resulting in increased concentrations of pimozide.
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Grapefruit juice may slightly delay the absorption of levothyroxine, but it seems to have only a minor effect on its bioavailability. Accordingly, the clinical relevance of the grapefruit juice-levothyroxine interaction is likely to be small.
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Notes for Consumers: Grapefruit juice may increase the actions of Tamsulosin and potentially increase its side effects. If the blood pressure drops too low while taking tamsulosin, you may become dizzy or feel faint. To limit this interaction, do not stand or sit up too quickly.
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In a case report, grapefruit juice was found to be a potential factor in a supratherapeutic INR. A 64-year-old male with atrial fibrillation who was taking warfarin was found to have an INR of 6.29 with no significant bleeding or bruising.
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Interactions between your drugs No interactions were found between grapefruit and Keppra. This does not necessarily mean no interactions exist.
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Some drugs, like statins used to lower cholesterol, are broken down by enzymes. As shown above, grapefruit juice can block the action of these enzymes, increasing the amount of drug in the body and may cause more side effects.
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Grapefruit contains a class of chemicals known to inhibit the process by which a number of drugs are broken down by the body (inactivated). This causes the concentration of drugs in the body to be higher than it should be, which can cause side effects.
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As to your question, grapefruit juice does have a mild effect on the blood-thinning drug warfarin (Coumadin). But I cannot find any solid evidence that it interacts with aspirin, which, like warfarin, reduces the tendency of blood to clot. So what to do if you enjoy drinking grapefruit juice?
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Tricor Food Interactions Fenofibrate can be used with other cholesterol-lowering medicines called statins. Grapefruit and grapefruit juice may interact with statins and lead to potentially dangerous effects. Discuss the use of grapefruit products with your doctor.
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Common Side effects of Grapefruit include: decreased levels of red blood cells.
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Aygestin may interact with griseofulvin, rifampin, St. John's wort, ketoconazole or itraconazole, barbiturates, or HIV medicines. Tell your doctor all medications you are taking. Smoking combined with this medication increases your risk for strokes, blood clots, high blood pressure, and heart attacks.
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Grapefruit juice decreases the ability of the gut to process sertraline.
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Grapefruit juice and certain statins (used to treat high cholesterol) such as Lipitor (atorvastatin), Mevacor (lovastatin), and Zocor (simvastatin) do not mix. Grapefruit juice inhibits a system of enzymes that helps break down dozens of medications, including Lipitor, Mevacor, and Zocor.
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If you eat grapefruit or drink grapefruit juice at all, be aware that the fruit interacts with several classes of drugs, including statins (taken to lower cholesterol), beta blockers (used to treat heart disease and regulate blood pressure), immune suppressing drugs, psychotropic drugs, and even certain anesthetics.
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Don't: Take Antibiotics With Dairy or Fruit Juice Take caution with grapefruit and citrus juices, and wait at least three hours after taking your prescription before consuming any dairy. Ask your doctor if it's safe to take other medications or supplements with your antibiotics to avoid harmful interactions.