how nsaids cause gi bleeding?
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By blocking the Cox-1 enzyme and disrupting the production of prostaglandins in the stomach, NSAIDs can cause ulcers and bleeding. Some NSAIDs have less effect on prostaglandins in the stomach than others, and, therefore, may have a lower risk of causing ulcers, but the increased risk of ulcers still exists.
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Ibuprofen is preferred over aspirin for ongoing conditions such as arthritis, menstrual cramps, and back pain. This is because the risk of gastrointestinal side effects increases the longer the duration of treatment and the risk of GI effects associated with aspirin use is already high.
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Many people take dangerously high amounts of ibuprofen. (Reuters Health) - Many adults who use ibuprofen and other so-called nonsteroidal anti-inflammatory (NSAID) drugs take too much, increasing their risk of serious side effects like internal bleeding and heart attacks, a U.S. study suggests.
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The serious risks from taking NSAIDs like Advil and Motrin are kidney failure, increased heart attacks and strokes in people at high risk, and rarely, liver failure. NSAIDs can also cause stomach ulcers and prolonged bleeding after surgery.
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['Heart—NSAIDs have been linked to a greater risk for heart attacks, strokes, and heart-related deaths. ... ', 'Stomach—People who take NSAIDs regularly are more likely to develop upset stomach symptoms, and potentially ulcers and bleeding in the gastrointestinal (GI) tract.']
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An overdose of these medications may cause stomach upset, abdominal pain, and vomiting. Larger amounts of NSAIDs can injure the kidneys. Also, they may cause ulcers, bleeding, seizures, and coma.
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Gastrointestinal symptoms are the most common side effects of NSAIDs. They are most likely to be stomach irritation and the sensations known as "heart burn" (which has nothing to do with your heart). In severe cases, NSAIDs can irritate the lining of your stomach so that an ulcer (a small erosion) forms.
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Common side effects of ibuprofen include nausea, dyspepsia, gastrointestinal ulceration/bleeding, raised liver enzymes, diarrhea, constipation, epistaxis (nose bleed), headache, dizziness, priapism, rash, salt and fluid retention, and hypertension (high blood pressure).
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Ulcers and bleeding in the stomach and intestine Because ibuprofen decreases how much prostaglandin you make, stomach damage such as bleeding and ulcers in the stomach and intestines is a possible side effect. This side effect is fairly rare. However, the risk increases the longer you use ibuprofen.
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Aleve is more likely than Advil to cause GI side effects because it is longer acting. To reduce the risk of GI side effects, NSAIDS should only be taken at their lowest effective dose, for the shortest possible time.
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Ibuprofen Thins the Blood All NSAIDs have an effect on the blood, ibuprofen included. While not as strong as some medicines (for example, aspirin), ibuprofen still slows down blood clotting time. This means that if you cut yourself, or have an injury, it may take longer to stop bleeding.
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Prostaglandins also help maintain the constant repair of your stomach lining, which protects you from damage from stomach acid. Because ibuprofen decreases how much prostaglandin you make, stomach damage such as bleeding and ulcers in the stomach and intestines is a possible side effect.
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Avoid aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen (Advil, Motrin) and naproxen (Aleve). They can cause you to bleed more. Ask your doctor if you can take acetaminophen (Tylenol). Read and follow all instructions on the label.
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A dangerous combination. Both aspirin and ibuprofen belong to a drug class called nonsteroidal anti-inflammatory drugs (NSAIDs). They have similar side effects, and taking them together increases your risk of these side effects. Aspirin and ibuprofen can cause stomach bleeding, especially if you take too much.
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Advil may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using ibuprofen, especially in older adults. Do not take more than your recommended dose. An Advil overdose can damage your stomach or intestines.
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NSAIDs possibly damage the normal large intestine, which presents as ulceration, colitis and stricture. Even though several studies found that NSAIDs can cause diverticular bleeding and perforation, flare-up of inflammatory bowel disease ,and play a role as an etiologic factor in lymphocytic colitis.
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Summary. The use of ibuprofen and Excedrin is generally not recommended due to the potential for the serious side effect of GI bleeding. The combination of these two products should be avoided, especially since alternative therapies exist for both ibuprofen and Excedrin.