is anti kpa clinically significant?
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Anti-Kpa alloantibody is known to be clinically significant and associated with both acute and delayed hemolytic transfusion reactions as well as hemolytic disease of the fetus and newborn (HDFN) [2], [3], [4]. Given the rarity of the Kpa antigen, antibodies to this antigen are not common.
154439
Moreover, PDW and MPV levels in severe sepsis patients were higher than in patients with sepsis. It has been demonstrated that coagulation and platelet activation/hyper aggregation can occur in an early phase of sepsis.
557085
In a case report, grapefruit juice was found to be a potential factor in a supratherapeutic INR. A 64-year-old male with atrial fibrillation who was taking warfarin was found to have an INR of 6.29 with no significant bleeding or bruising.
1233200
25. In non-competitive inhibition, the Km does not change. This is because Km is a measure of the affinity of the enzyme for its substrate and this can only be measured by active enzyme. The fixed amount of inactive enzyme in non-competitive inhibition does not affect the Km and the Km, therefore is unchanged.
1236540
Anticoagulant or anti-thrombotic drugs such as Heparin and Low Molecular Weight Heparin will cause the INR to be higher because they are affecting the coagulation cascade directly. The second category includes heparin in the sample, anti-phospholipid antibodies in the sample, and hematocrit.
802391
The 2017 ACC/AHA guideline recommends treating SBP/DBP to <130/80 mm Hg for all adults taking antihypertensive medication (1). Hypertension is highly prevalent in adults with atrial fibrillation (AF), especially those >60 years of age, and affects ∼1 billion adults worldwide (3).
536781
The presence of ANA antibodies was found in 24% of people with type 1 diabetes and 22% of people with type 2 diabetes. There was no correlation between the presence of ANA antibodies ANA and duration of diabetes.
144214
Serum antinuclear antibodies (ANAs) are positive in some patients with chronic lymphocytic leukemia (CLL), but the prognostic value of ANAs remains unknown. The aim of this study was to evaluate the role of ANAs as a prognostic factor in CLL.
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The MOPPETT trial demonstrated that half-dose thrombolytics (50 mg tPA) might safely reduce the rate of recurrent PE and late-onset pulmonary hypertension in intermediate risk pulmonary embolism.
84297
An AFP level of less than 10 ng/mL is normal for adults. An extremely high level of AFP in your blood—greater than 500 ng/mL—could be a sign of liver tumors. High levels of AFP may mean other cancers, including Hodgkin disease, lymphoma, and renal cell carcinoma (kidney cancer).
1275236
Noncontrast chest CT scan has a good role in the evaluation of PE through detection of the hyperdense lumen sign, which is a good indicator of acute pulmonary thromboembolism, particularly in cases involving the central pulmonary arteries or peripheral wedge-shaped opacity, as a useful indirect sign.
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Several studies showed that blood pressure and lung function are associated. Additionally, a potential effect of antihypertensive medication, especially beta-blockers, on lung function has been discussed.
332837
ACE inhibitors are associated with a dry, persistent cough in 5%-35% of patients who take them. The mechanism of cough is likely multifactorial. ACE inhibitors prevent the breakdown of bradykinin and substance P, resulting in an accumulation of these protussive mediators in the respiratory tract.
1359024
The Zytiga started to work quickly. “Within two weeks, 100 percent of the pain was gone,” says Jeff. “Here we are, two months later; I haven't so much as taken an aspirin in six weeks. I had my PSA checked last week: it had dropped to .
888431
If the elevation persists, hepatic ultrasonography and further testing for uncommon causes should be considered. Mild, asymptomatic elevations of alanine transaminase (ALT) and aspartate transaminase (AST) levels, defined as less than five times the upper limit of normal, are common in primary care.
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PATHOPHYSIOLOGY The clinical features of ACE inhibitor-induced angioedema are related to elevated levels of bradykinin, an inflammatory vasoactive peptide, which leads to vasodilation of blood vessels.
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This standardization makes the ANA test very sensitive for the diagnosis of autoimmune diseases but results in many false positive results. At a dilution of 1:160, only 5 percent of normal individuals have a positive test for ANA.