how do calcium channel blockers cause urinary incontinence?
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Calcium Channel Blockers: Calcium channel blockers decrease smooth-muscle contractility in the bladder. This causes urinary retention and, accordingly, leads to overflow incontinence.
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The problem can also be caused by using drugs such as antihistamines (like Benadryl®), antispasmodics (like Detrol®), and tricyclic antidepressants (like Elavil®) that can change the way the bladder muscle works. Passing your urine occurs when the brain tells the bladder muscle to tighten.
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Verapamil has a more profound effect on gut smooth muscle than the other calcium channel antagonists. It reduces gut motility and causes constipation. Like verapamil, diltiazem is an arteriolar dilator which reduces peripheral resistance and thus blood pressure, but it is less cardio depressant.
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BPH medications and sexual side effects This is because alpha-blockers relax the bladder and prostate muscle cells. Alpha reductase inhibitors can also cause ED. Additionally, reduced sex drive is a possible side effect of the alpha reductase inhibitors dutasteride and finasteride.
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Alpha blockers. These medications relax bladder neck muscles and muscle fibers in the prostate, making urination easier. Alpha blockers — which include alfuzosin (Uroxatral), doxazosin (Cardura), tamsulosin (Flomax) and silodosin (Rapaflo) — usually work quickly in men with relatively small prostates.
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Abstract. Calcium channel or entry blockers (CEBs) exert important vascular and tubular effects on the kidney. These renal effects include an enhancement of glomerular filtration rate (GFR), renal blood flow (RBF), and electrolyte excretion.
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Calcium channel blockers lower blood pressure and treat other conditions such as chest pain and an irregular heartbeat. Calcium channel blockers lower your blood pressure by preventing calcium from entering the cells of your heart and arteries.
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There are many possible causes of urinary blockage, such as: Kidney stones. Tumors and cancers of the urinary system, prostate gland, or female organs. A narrowing of the urethra (urethral stricture) in men caused by scar tissue from previous infections or surgical procedures.
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Alpha-blockers work by relaxing the muscles in the prostate and bladder, allowing urine to flow more easily. However, treatment involving only silodosin is often not effective enough in reducing urinary symptoms. Tadalafil can help improve urinary symptoms due to BPH.
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['Diuretics (pills that cause an increase in urine flow).', 'Antihypertensives (medication for high blood pressure).', 'Antihistamines.', 'Antidepressants.', "Parkinson's disease drugs.", 'Antiarrhythmics (medication for irregular heart action).', 'Tranquilizers.', 'Muscle relaxants.']
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Calcium channel blockers are drugs used to lower blood pressure. They work by slowing the movement of calcium into the cells of the heart and blood vessel walls, which makes it easier for the heart to pump and widens blood vessels. As a result, the heart doesn't have to work as hard, and blood pressure lowers.
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Medications Which Potentially Can Cause Incontinence Symptoms. Adrenergic agonists or alpha-blockers (medications for high blood pressure and benign prostatic hyperplasia (BPH)) may relax the muscles of the bladder neck, which may cause stress urinary incontinence or urine leakage.
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Decongestants and Antihistamines Such drugs, known as adrenergics, can worsen urinary symptoms by preventing muscles in the prostate and bladder neck from relaxing to allow urine to flow freely. Antihistamines, such as diphenhydramine (Benadryl, generic), can also slow urine flow in some men with BPH.
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Calcium-channel inhibitors acting on skeletal muscles It reduces the force of contraction of the striated muscles by inhibiting the calcium release from the sarcoplasmic reticulum, probably by inhibiting the ryanodine receptors.
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Dihydropyridine CCBs (e.g., nifedipine, amlodipine) primarily act on vascular smooth muscles. Nondihydropyridine CCBs (diltiazem < verapamil) primarily act on the heart.
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Calcium channel blockers lower your blood pressure by preventing calcium from entering the cells of your heart and arteries. Calcium causes the heart and arteries to contract more strongly. By blocking calcium, calcium channel blockers allow blood vessels to relax and open.
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In conclusion, the risk that duloxetine will cause urinary retention seems limited. However, some patients may experience weak obstructive voiding symptoms most likely caused by peripheral adrenergic activity affecting the smooth urethral muscle or modifying the unique bladder-urethra synergy.