do b cells require antigen presentation?
150797
While B cells can interact with soluble antigens, it is now clear that the presentation of membrane-bound antigen plays a crucial role in B cell activation, and in particular during affinity-maturation, the process during which high-affinity B cells are selected.
1318262
The first antibodies made by a newly formed B cell are not secreted. Instead, they are inserted into the plasma membrane, where they serve as receptors for antigen. ... Each B cell produces a single species of antibody, each with a unique antigen-binding site.
1216743
The terminal differentiation of a B cell is becoming a plasma cell which is essentially a cell devoted to secreting antibodies. From the germinal center or the memory B cell population, antigen specific B cells will proliferate (in the presence of the antigen) and become plasmablasts and then plasma cells.
509871
Immature B cells express CD19, CD 20, CD34, CD38, and CD45R, but not IgM. For most mature B cells the key markers include IgM and CD19, a protein receptor for antigens (Kaminski DA. ... Plasma B cells lose CD19 expression, but gain CD78, which is used to quantify these cells.
394259
Plasma cells are key to the immune response because they secrete antibodies. ... Because these organelles are responsible for providing most of the ATP needed by the cell, they are often referred to as the "powerhouses" of the cell.
1080974
Abstract. Dendritic cells are the most efficient antigen-presenting cells. ... Indeed, dendritic cells are the only antigen-presenting cells that induce the activation of resting T cells, both in vitro and in vivo. Thus, dendritic cells initiate adaptive immune responses and determine tolerance.
1114993
B-cell activation by armed helper T cells. ... The peptide:MHC class II complex can be recognized by antigen-specific armed helper T cells, stimulating them to make proteins that, in turn, cause the B cell to proliferate and its progeny to differentiate into antibody-secreting cells.
1112704
The T and B lymphocytes (T and B Cells) are involved in the acquired or antigen-specific immune response given that they are the only cells in the organism able to recognize and respond specifically to each antigenic epitope. ... Thus, humoral immunity depends on the B Cells while cell immunity depends on the T Cells.
837525
There are two types of B cells: Plasma B cells secrete antibodies which effect the destruction of antigens by binding to them and making them easier targets for phagocytes.
85682
Antigens are molecules capable of stimulating an immune response. Each antigen has distinct surface features, or epitopes, resulting in specific responses. Antibodies (immunoglobins) are Y-shaped proteins produced by B cells of the immune system in response to exposure to antigens.
1413160
antigen-presenting cell (APC) A specialized type of cell, bearing cell surface Class II MHC (major histocompatibility complex) molecules, involved in processing and presentation of antigen to inducer, or helper , T cells.
1230633
Dendritic cell–B-cell interaction: dendritic cells provide B cells with CD40-independent proliferation signals and CD40-dependent survival signals. Immunology.
567921
Granulocytes acquire antigen-presenting cell (APC) features via bystander activation from neighboring professional APCs stimulating T cells. Antigen presentation initiated by dendritic cells (DCs) or other professional APCs leads to stimulation of T cells ...
526674
B cells, in addition to their function in antibody production, also express high level of MHC class II and can present antigens to CD4+ T cells.
805886
Requirements of an effective vaccine include all of the following: does not require numerous doses or boosters, has a low level of adverse side effects or toxicity, stimulates both B cell and T cell responses (not only humoral immunity), achieves long-term, lasting effects, and is inexpensive to produce.
768743
Unlike T cells that recognize digested peptides, B cells recognize their cognate antigen in its native form. The B cell receptor used in recognition can also be secreted to bind to antigens and initiate multiple effector functions such as phagocytosis, complement activation, or neutralization of receptors.
999959
Although T and B cells both react with molecules that are termed “antigens,” these lymphocytes actually respond to very different types of molecules. B cells must be able to bind intact antigens because they secrete antibodies that must recognize the pathogen directly, rather than digested remnants of the pathogen.