what are trk fusion cancers?
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One type of genetically-driven cancer is called tropomyosin receptor kinase (TRK) fusion cancer. Neurotrophic tyrosine receptor kinase (NTRK) genes provide instructions for TRK proteins. When an NTRK gene joins or “fuses” with an unrelated gene, it starts to produce an altered TRK fusion protein.
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Leukemia, lymphoma, and multiple myeloma are all cancers of the blood-forming organs, or hematopoietic neoplasms. They arise due to errors in the genetic information of an immature blood cell.
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Cell fusion is an important cellular process in which several uninuclear cells (cells with a single nucleus) combine to form a multinuclear cell, known as a syncytium. Cell fusion occurs during differentiation of muscle, bone and trophoblast cells, during embryogenesis, and during morphogenesis.
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['Lung cancer.', 'Stomach cancer.', 'Bladder cancer.', 'Esophageal cancer.']
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Gestational trophoblastic disease (GTD) is a group of rare tumors that involve abnormal growth of cells inside a woman's uterus. GTD does not develop from cells of the uterus like cervical cancer or endometrial (uterine lining) cancer do.
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Acronym. Definition. TCKR. Tumor Cell Kill Rates. Copyright 1988-2018 AcronymFinder.com, All rights reserved.
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The BRAF protein is a serine/threonine-kinase involved in the mitogen-activated protein-kinase (MAPK) signaling pathway (B-Raf/Mek/Erk proteins).
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Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. ... Mutations in receptor tyrosine kinases lead to activation of a series of signalling cascades which have numerous effects on protein expression.
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Worldwide rare cancers make up 22 out of every 100 (22%) of cancers that are diagnosed each year. This means that 1 in 5 people diagnosed with cancer has a rare type. Research also shows that about 1 in 3 people with a rare cancer have a particularly rare type.
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GIST and Neuroendocrine Cancers Gastrointestinal stromal tumors (GIST) are rare tumors of the GI tract. GIST tumors start in in the wall of the GI tract; most occur in the stomach and others in the small intestine. Cancers that develop from the neuroendocrine cells are called neuroendocrine tumors.
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The Nck (non-catalytic region of tyrosine kinase adaptor protein 1) belongs to the adaptor family of proteins. The nck gene was initially isolated from a human melanoma cDNA library using a monoclonal antibody produced against the human melanoma-associated antigen.
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['Rare SKIN cancers and NON-CUTANEOUS MELANOMA.', 'Rare THORACIC cancers (mesothelioma, thymoma, rare lung cancers, rare breast cancers)', 'Rare UROGENITAL cancers (kidney cancers, bladder cancers, urinary tract cancers)']
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Soft tissue sarcoma is a rare type of cancer that begins in the tissues that connect, support and surround other body structures. This includes muscle, fat, blood vessels, nerves, tendons and the lining of your joints. More than 50 subtypes of soft tissue sarcoma exist.
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Bouvier des Flandres – Bouviers are predisposed to gastric carcinoma, a type of malignant stomach cancer. A cooperative study from Denmark and Norway looked for breed predisposition to gastric carcinoma, and they found that Bouviers fell into the high- risk group for developing this type of stomach cancer.
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In 2011, the FDA found a link between breast implants and a type of rare cancer known as breast implant-associated anaplastic large cell lymphoma. The exact causes of this cancer aren't understood but textured implants may be linked to more cases than smooth implants.
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Transitional cell cancer (TCC) is a rare type of kidney cancer. It starts in cells called transitional cells. There are many different types of cells in the body, each with a particular job to do. Transitional cells are able to change shape and stretch.
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High-risk, non-muscle-invasive bladder cancer is defined as any transitional cell carcinoma (TCC) of the bladder that is high-grade, whether it is primary or recurrent.