what is the most significant change in kidney function that occurs with aging?
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Conclusions. Senescence or normal healthy aging of the kidney is characterized by progressively increasing nephrosclerosis with loss of functional glomeruli and decreased overall kidney function as determined by GFR.
1440058
All cells experience changes with aging. They become larger and are less able to divide and multiply. Among other changes, there is an increase in pigments and fatty substances inside the cell (lipids). Many cells lose their ability to function, or they begin to function abnormally.
1242514
Which best describes the function of the kidneys? Filtering blood, removing wastes and regulating water balance.
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Chronic kidney disease, also called chronic kidney failure, describes the gradual loss of kidney function. Your kidneys filter wastes and excess fluids from your blood, which are then excreted in your urine.
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['Acute kidney failure has an abrupt onset and is potentially reversible.', 'Chronic kidney failure progresses slowly over at least three months and can lead to permanent kidney failure.']
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Overview. Chronic kidney disease, also called chronic kidney failure, describes the gradual loss of kidney function. Your kidneys filter wastes and excess fluids from your blood, which are then excreted in your urine.
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['eating more.', 'menstrual cycle.', 'perimenopause and menopause.', 'metabolism slowing down with age.', 'being less physically active.', 'water retention due to dehydration or excess salt.', 'stress, depression, or anxiety.', 'lack of sleep.']
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For a 60-year-old man, stage 1 kidney disease life expectancy will be approximately 15 years. That figure falls to 13 years, 8 years, and 6 years in the second, third, and fourth stages of kidney disease respectively. For a 60-year old woman, stage 1 life expectancy is 18 years, while stage 2 is only one year less.
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Stage 3 Kidney Disease Life Expectancy A patient enters Stage 3 chronic kidney disease (CKD) when their glomerular filtration rate, or GfR, is reduced to between 30-59% This indicates decreased kidney function and moderate kidney damage.
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AKI is usually reversible. In contrast, CKD develops gradually, over months to years, as a result of chronic illnesses such as diabetes and hypertension. Patients are often asymptomatic and CKD is discovered incidentally on routine screening or workup of unrelated diseases.
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Clinical importance of the GFR A decrease or decline in the GFR implies progression of underlying kidney disease or the occurrence of a superimposed insult to the kidneys. This is most commonly due to problems such as dehydration and volume loss.
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['Constipation.', 'Kidney stones.', 'Kidney failure.', 'Heart function problems.', 'Confusion and cognitive problems.']
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Kidney Disease Your kidneys get rid of waste and extra fluid from your body. One of the first signs that something is wrong is puffiness in your fingers, feet, and around your eyes. You're more likely to get kidney disease if you have diabetes or high blood pressure.
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Human aging, physiological changes that take place in the human body leading to senescence, the decline of biological functions and of the ability to adapt to metabolic stress.
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Elevated BP leads to damage of blood vessels within the kidney, as well as throughout the body. This damage impairs the kidney's ability to filter fluid and waste from the blood, leading to an increase of fluid volume in the blood—thus causing an increase in BP.
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Reduced Kidney Function A number of kidney problems make tubules less efficient at filtrate processing and water reabsorption. In these conditions, urine output may actually increase because the damaged tubules cannot handle the filtrate load.
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For the elderly, the life expectancy shortens even further, once they reach the end-stage renal disease. Individuals aged 60 years to 85 years have a life expectancy of 6 years and one and a half or one year, respectively.