Shionogi Shares Slide on European Panel&#39;s Crestor Safety Review
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Shionogi Co. shares fell as much as 13.2 percent in early trading in Tokyo after a European Union health panel said it will review the safety of AstraZeneca Plc&#39;s Crestor cholesterol reducer.
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Japan&#39;s Nikkei average sank 1.69 percent to below the key 11,000 mark by mid afternoon on Friday with stocks across the board losing ground after the government surprised the market by revising down economic growth figures.
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Japanese stocks fell by midday on  Thursday as concerns over domestic company earnings and the  impact on global economies of higher oil prices overshadowed  bargain hunting following the market's recent sharp losses.
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Japanese stocks fell sharply Friday, led by steels, machinery and real estate shares, buffeted by Wall Street's overnight drop and weaker-than-expected Japanese machinery data.
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Japan&#39;s Nikkei 225 Stock Average fell for the first day in four. Nintendo Co. and Sharp Co. declined after brokerages cut their ratings on the companies, citing concern that earnings growth may slow.
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The Nikkei average fell 1 percent by  midsession on Thursday after sharp declines in metals prices  pushed down shares of steel makers and mining companies, which  had been big gainers over the past three months.
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Tokyo's Nikkei average slipped 0.07 percent by midday on Wednesday, pressured by falls in real estate firm Mitsui Fudosan Co. and others dependent on domestic demand after growth data came in weaker than expected.
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Japanese shares fell Friday after Japanese banks reported larger-than-expected losses due to the subprime mortgage crisis. A slump in China's Shanghai Stock Exchange also weighed on Tokyo trade.
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Tokyo&#39;s Nikkei average was down 0.4 percent by midsession on Monday on selling of exporters like Toyota Motor Corp., which announces results later in the day, and wariness ahead of the US presidential election.
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Japan&#39;s Nikkei 225 Stock Average fell 39.75, or 0.4 percent, to 10,731.67 at 9:02 am in Tokyo. The broader Topix index dropped 3.93, or 0.4 percent, to 1081.
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Tokyo shares tumbled to their lowest close in two weeks on Wednesday, battered by an overnight tumble in US stock markets and the yen hitting a one-month high against the dollar.
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Stocks fell, with the S&P briefly down 1 percent, on Friday as declines in defensive shares and talk of more trouble in the global financial sector offset strong earnings from companies, including Honeywell International Inc .
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Japan's main stock index fell Friday to a two-year low as investors worried about upcoming earning reports from U.S. financial groups.
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Japanese stocks fell Thursday after financial shares came under pressure from a larger-than-expected loss at U.S. brokerage firm Merrill Lynch due to fallout from U.S. subprime mortgage problems. Exporters were also sold off on the yen's strength against the dollar.
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Tokyo stocks tumble across the board    TOKYO, May 25 (Xinhua) -- Tokyo stocks tumbled across the board Friday.   The 225-issue Nikkei Stock Average fell 215.76 points, or 1.22 percent, to 17,481.21, ending below the 17,500 line for the first time in a week.
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Japan's Nikkei share average fell nearly  one percent on Tuesday after the dollar's retreat below 103 yen  put pressure on exporters such as Sony Corp.
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Japan&#39;s stock market was weighed down on Thursday morning by a combination of overnight drops in the US and European markets and a rise in the yen.