Instruct: Classify Amazon reviews into positive or negative sentiment
Query: Tylosin is a macrolide-class antibiotic. It can be dangerous.

Tear staining is a natural oxidizing process where the enzymes in the tears react with air and natural bacteria on the skin. This product contains a low dose antibiotic called Tylosin that disrupts this normal physiology. You are literally 'treating' your dog with a daily dose of antibiotic. It is not considered responsible use of antibiotics by many veterinarians. The safety of long term use of antibiotics like this have not been properly studied and are likely to cause long term effects. This is why many people have reported GI signs in the reviews. The best thing you can do to reduce tear staining is gently wipe the area with warm water every morning as well as routine grooming. If tear staining continues to be a major issue for you - DO NOT GET A WHITE DOG NEXT TIME.