COX-2 inhibitor, Bextra, Shows Problems in Heart Patients
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Two small clinical trials showed heart bypass surgery patients taking Bextra, an anti-inflammatory in the same class as the recently withdrawn drug Vioxx, had an increased risk of stroke and heart attack.
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Vioxx was associated with higher odds of heart attack than Celebrex, but the difference may be due to a number of factors, including differences in selectivity for the COX-2 isoenzyme, blood pressure, endothelial function and oxidative stress.
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The U.S. Food and Drug  Administration on Thursday ordered the review of preventative  studies involving Pfizer Inc.'s painkillers Celebrex and  Bextra, in light of recent evidence they may increase the risk  of heart attack and stroke.
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People taking nonsteroidal anti-inflammatory drugs (NSAIDs) who suddenly stop face an almost 50 percent increased risk for having a heart attack during the first few weeks
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NEW YORK - A new round of trials have shown a boosted risk of heart problems among patients taking the painkiller Celebrex, manufacturer Pfizer Inc.
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Doctors writing in a prominent medical  journal on Friday recommended that physicians stop prescribing  Pfizer Inc.'s Bextra painkiller, just as a large study found  the drugmaker's sister drug, Celebrex,  doubled risk of heart  attacks.
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Scientists uncover why some arthritis drugs such as Vioxx can cause heart attacks and strokes.
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Pfizer Inc.'s Bextra will come with  a new warning about possible heart and blood clotting problems  when the drug is used by patients who have just had heart  bypass surgery, the U.S. Food and Drug Administration said on  Thursday.
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Like Vioxx, which was taken off the market in September because of safety concerns, Celebrex is a COX-2 inhibitor, a type of drug that eases the inflammation associated with arthritis typically without damaging the stomach.
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Users of an anti-arthritis drug have been warned that it could cause an increased risk of heart attacks and strokes. A new study linked the drug to the health risks, but users of Celebrex (celecoxib), manufactured
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OTTAWA - Health Canada is warning people about heart and skin problems associated with the painkiller Bextra. Bextra (valdecoxib), which is used to treat arthritis and menstrual pain, belongs to a class of
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Pfizer Inc. on Friday said two small clinical trials showed heart bypass surgery patients taking Bextra, an anti-inflammatory in the same class as the recently withdrawn
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Two Boston doctors are cautioning physicians to prescribe pain relievers called cox-2 inhibitors such as Celebrex only as a last resort in patients at risk for heart attacks.
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A new study finds that Celebrex, the first in a family of stomach-friendly painkillers called cox-2 inhibitors, is safer for the heart than Vioxx, a similar drug that has been linked to cardiovascular problems.
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Oct. 6, 2004 - Scientists in the United States and regulatory agencies in Europe on Wednesdsay questioned whether Celebrex and other pain relievers might raise the same risk of heart problems as those blamed on the arthritis medicine Vioxx.
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The arthritis drug Bextra will begin carrying a warning on the label about possible heart and blood-clotting problems, the Food and Drug Administration said yesterday.
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Pfizer Inc. PFE.N on Friday said two  small clinical trials showed heart bypass surgery patients  taking Bextra, an anti-inflammatory in the same class as the  recently withdrawn drug Vioxx, had an increased risk of stroke  and heart attack.