d high-quality clinical trials and systemic reviews are needed in the future to demonstrate the efficacy and safety of PRP applied in TKA.

Acknowledgments
===============

The authors thank the staff members of this trial and our colleagues for their enormous efforts in collecting and ensuring the accuracy and completeness of all the data.

Abbreviations: CI = confidence interval, Development and Evaluation, DVT = deep vein thrombosis, GRADE = Grading of Recommendations Assessment, Development, and Evaluation, Hb = hemoglobin, LOS = length of hospital stay, MD = mean difference, PE = pulmonary embolism, POD = postoperative day, PRP = platelet-rich plasma, RCTs = randomized controlled trials, ROM = range of motion, TKA = total knee arthroplasty, VTE = venous thrombus embolism, WOMAC = Western Ontario and McMaster Osteoarthritis Index.

The authors report no conflicts of interest.

JM and JS are joint first authors.

This study was supported by the Science and Technology Research Fund for the Returned Personnel of Ministry of Human Resources and Social Security of China (No. 2014--QTL--028) and China--Japan Friendship Hospital Youth Science and Technology Excellence Project (No. 2015--QNYC--A--03).


The 2015 European Society of Cardiology (ESC)/European Respiratory Society (ERS) Pulmonary Hypertension (PH) Guidelines have been developed by a Task Force Committee reflecting on the multidisciplinary nature of PH ([@ref1]). The recommendations of the new guidelines were presented and discussed by Cihangir Kaymaz, MD, National Reviewer of 2015 ESC/ERS PH Guidelines, in a session entitled "Pulmonary Hypertension in Turkey" in the ESC Congress 2015. In this session, the management of a PH case that was presented by Barış Kaya, MD was also discussed within the frame of the new recommendations. This review article summarizes Dr. Kaymaz's talk: "What Do the New Guidelines Tell Us?"

***Changes in hemodynamic and clinical definitions:*** PH is defined as an increase in the mean pulmonary arterial pressure (\>25 mm Hg) at