ads.

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###### Additional file 11

Table S10: A list of positions that are share same genotypes between the reference genome and those from the newly sequenced *S. aureus*subsp. USA300 cell line.

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Acknowledgements
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This publication was made possible by NIH Grant \#P20 RR016454 from the INBRE Program of the National Center for Research Resources and by supports from Boise State University. I am thankful for the critical reading of the manuscript by my daughter Michelle Yu and my English tutor Ruth Paul at Boise State University.


Introduction {#s1}
============

The ongoing pandemic of a coronavirus-associated acute respiratory disease called coronavirus disease 19 (COVID-19), is the third documented spillover of an animal coronavirus to humans in only two decades ([@B1]). In 2011, Weiss and Leibovitz ([@B2]) concluded their Chapter on Coronavirus Pathogenesis by asking "Will SARS or another HCoV emerge from its reservoir? It seems like this could happen again given the identification of numerous bat SARS-like viruses and the finding of SARS-like virus in animal such as the civet." This sentence sounded prophetic, especially now during the COVID-19 pandemic. Globally, COVID-19 is highlighting that preparedness toward pandemics is still not adequate to effectively deal with what is unknown. However, Asian countries that previously experienced similar epidemics (e.g., SARS) demonstrated a prompt and appropriate response aimed at containing viral spread and reducing disease impact.

Indeed, the rapid spreading of the virus across the world has exposed major gaps in the abilities of most countries to respond to a virulent new pathogen. The WHO-China Joint mission report ([@B3]) concludes that it is imperative to timely fill the knowledge gaps in the natural history of the disease to put in place effective control strategies ([@B4]) such as effective diagnostic tools, vaccines, and antivirals.

SARS-CoV- 2 is (only) the seventh coronavirus know