ention are required to be performed under general anesthesia (Class IIIb) or local anesthesia (Class IIIa); Grade IV complications: intensive care is required due to single or multiple organ failure; Grade V complications: death.[@CIT0017]

Statistical Analysis {#S0002-S2005}
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Statistical analyses were performed using IBM SPSS Statistics23.0 (IBM SPSS Inc., Chicago, IL). Descriptive statistics were performed on the distributions of demographic characteristics and perioperative complications. Continuous data were described as mean ± standard deviation and categorical data as number (percentage). Continuous variables were compared using the Student *T*-test or Mann--Whitney *U*-test. Categorical variables were compared using the Chi-square test or Fisher's exact test. Two-level logistic regression model was used to evaluate the risk factors between NACT and perioperative and severe complications. Two-level logistic regression model was used to estimate the odds ratio (OR) and the 95% confidence interval (CI) of the risk of perioperative complications by analysis of multiple clinical indicators. Variables with *p*\<0.05 in the univariate analysis were considered in a multivariate analysis. *P*\<0.05 was considered statistically significant.

Results {#S0003}
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Patient Characteristics {#S0003-S2001}
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The demographic characteristics of the study population are shown in [Table 1](#T0001){ref-type="table"}. 805 patients receiving RRH were included in the study, among which, 244 patients (30.31%) underwent NACT and 561 patients (69.69%) did not receive NACT. 439 patients (54.53%) were in stage IA-IB and 366 patients (45.47%) were in stage II or above by FIGO staging. Medium differentiation of tumor grade and squamous of histology cell were observed at highest frequency in 489 (60.75%) and 641 (79.63%), respectively. 164 patients (20.37%) had preoperative comorbidities with ASA score ≥ 3. Type 16 and 18 of HPV were regarded as relatively high risk for cervical carcino