lcaps}Mean[se]{.smallcaps}*P*Ages (years)3·60·422·80·484·80·6Weight (kg)32·170·9129·371·4219·531·15Basal glucose (mg/dl)\*73·02^b^2·9083·41^a^1·3388·06^a^1·810·0047Basal insulin (μU/ml)†20·34^a^3·7912·52^a,b^1·596·47^b^0·980·0065Baseline fructosamine (μmol/l)259·54^a^9·89236·36^b^3·99270·17^a^9·890·0160HOMA index2·60^a^0·032·56^a,b^0·311·40^b^0·210·0298Minimum glucose (mg/dl)\*63·18^b^1·5876·23^a^1·4378·19^a^0·85\<0·0001Mean blood glucose (mg/dl)\*‡79·42^b^1·2287·63^a^0·8887·90^a^0·680·0020Maximum blood glucose (mg/dl)\*91·92^b^3·9899·12^a,b^1·22100·26^a^1·160·0359[^1][^2][^3][^4][^5]

With regards to postprandial glucose responses, an interaction was observed between time of collection and the experimental groups on the glycaemic curve (*P* = 0·0007), with fluctuations over time in G1 (5-min difference between 60, 120, 180 and 360 min, and 10-min difference between 180 and 360 min) and in minor proportions on G2 (10-min difference in 300 min). A similar behaviour was observed on glucose increment analysis (*P* = 0·0006). When glycaemic curves of the experimental groups were compared over time, higher glucose concentrations were observed in G3 than those in G1 at 5, 10 and 15 min ([Fig. 1(a)](#fig01){ref-type="fig"} and [Table 1](#tab01){ref-type="table"}). Fig. 1.Values of blood glucose (a), insulin (c) and their respective increments (b, d) obtained by postprandial response tests of the healthy/control group (![](S2048679017000593_inline1.jpg)), carrier females (![](S2048679017000593_inline2.jpg)) and affected dogs (![](S2048679017000593_inline3.jpg)). Values are means with their standard errors represented by vertical bars. \* Mean value was significantly different from those of control and carrier dogs (*P* \< 0·05; Tukey\'s test and ANOVA). To convert glucose in mg/dl to mmol/l, multiply by 0·0555. To convert insulin in μU/ml to pmol/l, multiply by 6·945.

In relation to postprandial insulin responses, an interaction was obser