study period need to be reported11. How well?Plan: To promote adherence to the recommended skin care practices among subjects participating in the educational program. A moisturizer is provided free of charge to those who want to use it12. How well?Practice: Strategies to promote adherence to skin care practices will be reported in a paper

Control arm {#Sec12}
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A leaflet summarizing the content of the educational program that is provided to the intervention arm is made available to subjects in the control arm at approximately 20 and 30 weeks of pregnancy.

Measurements/assessments {#Sec13}
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### Primary outcomes {#Sec14}

#### Self-evaluation of questionnaire to identify the behavioral characteristics of mothers based on the educational program at 4 months after delivery {#FPar1}

Primary outcomes are evaluated according to a self-evaluation score at 4 months after delivery in both arms.

The score is determined using a survey sheet created for this study ([Appendix](#Sec43){ref-type="sec"}) to assess the behavioral characteristics of mothers. We prepared 21 questions to assess the dietary habits of mothers, living conditions, and the skin care of children based on the ideal behavior of mothers to prevent allergy in infant as proposed by specialists. Five options (a--e) are provided for all questions: a = 1, b = 2, c = 3, d = 4, and e = 5. Higher scores indicate more appropriate behaviors of mothers to prevent pediatric allergy at each time point.

### Secondary outcomes {#Sec15}

We set the following seven secondary outcomes: Incidence and severity of atopic dermatitis and eczema infantile

The incidence and severity of AD and eczema in infants aged 1 week, 1 month, 4 months, and 12 months are determined by a "blinded" pediatrician according to the Clinical Practice Guidelines for the Management of Atopic Dermatitis 2016 prepared by the Japanese Dermatological Association: URL:<https://www.dermatol.or.jp/uploads/uploads/files/guideline/atopic