borators. 50 scholars/collaborators visited the Center for up to six months seeking technical and scienti?c expertise, and 107 leading scientists presented their work on the Center Seminar program at the host institution, the UIUC Beckman Institute. All the activities described above were possible only through the Center's Petascale Biology Gateway Facility, which provides the high-end computing and graphics resources required by the demanding preparation, visualization, and analysis tasks of advanced molecular modeling. This gateway also hosts the Center's website and all associated content, from scienti?c research-related material to software documentation and tutorials, as well as the online discussion platforms.

The objective of this proposal is to research the technical and commercial feasibility of a novel wrist brace that reduces the risk for wrist fracture by resisting wrist terminal extension while otherwise allowing unconstrained movement throughout the normal range of motion. The novel wrist brace will be designed, fabricated, and validated in our laboratory under simulated impact conditions. The long-term goal of the product is to determine the efficacy of the brace on snowboarding and in-line skating populations using a prospective, randomized, longitudinal study. Wrist braces offer limited protection against distal radius fractures, yet they have achieved limited acceptance, particularly among youths, because they are bulky and limit normal range of motion. Research has also demonstrated that they do not prevent fractures under high impact energy loading conditions. We postulate that wrist guard usage will increase significantly with a device that is less constraining and which offers increased protection against distal radius fractures

Summary: The purpose of the research is to study the cellular and molecular mechanisms of adaptation to stress with emphasis on the regulation of the various components of the hypothalamic pituitary adrenal (HPA) axis. This includes the expression of hypothalamic c