eline, the mean difference was 0.4 ms (95% CI: −7.3 to 8.2 ms; *P* = 0.91) and *I* ^2^ was reduced to 19%. Therefore, different method of T~end~ determination contributed heterogeneity to the pooled effect estimate. Moreover, statistical significance was achieved when the tangent method was used, but was lost when the return to baseline method was used, which may suggest the former approach may be more sensitive.

![Forest plot demonstrating T~peak~‐T~end~ dispersion obtained from event‐positive (A) and event‐negative (B) groups and the mean difference between both groups (C) in Brugada Syndrome](JOA3-34-587-g004){#joa312118-fig-0004}

3.4. Comparisons between patients with and without SCN5A mutations {#joa312118-sec-0013}
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SCN5A is the commonest ion channel gene that is mutated in Brugada syndrome.[2](#joa312118-bib-0002){ref-type="ref"}, [3](#joa312118-bib-0003){ref-type="ref"} Separate meta‐analyses were conducted to compare the different T~peak~‐T~end~ parameters between patients with and without SCN5A mutations. Two of the included studies provided sufficient information for such analyses.[7](#joa312118-bib-0007){ref-type="ref"}, [14](#joa312118-bib-0014){ref-type="ref"} No significant difference in T~peak~‐T~end~ (mean difference = 8.2 ms, 95% CI: −6.7 to 23.2 ms, *P* = 0.28; *I* ^2^ = 59%; Figure [S7](#joa312118-sup-0001){ref-type="supplementary-material"}), T~peak~‐T~end~/QT ratio (mean difference = −0.006 ms, 95% CI: −0.023 to 0.011 ms, *P* = 0.47; *I* ^2^ = 24%; Figure [S8](#joa312118-sup-0001){ref-type="supplementary-material"}) or T~peak~‐T~end~ dispersion (mean difference = 5.2 ms, 95% CI: −2.9 to 13.2 ms, *P* = 0.21; *I* ^2^ = 31%; Figure [S9](#joa312118-sup-0001){ref-type="supplementary-material"}) was observed between patients with and without SCN5A mutations.

4. DISCUSSION {#joa312118-sec-0014}
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The main findings of our meta‐analysis, which included 1597 Bru